Results 131 to 140 of about 220,443 (295)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Oscillatory hyperpolarizations and resting membrane potentials of mouse fibroblast and macrophage cell lines

, 1984
L cells (a mouse fibroblast cell line) and macrophages have been reported to exhibit slow oscillatory hyperpolarizations and relatively low membrane potentials, when measured with glass micro-electrodes.
Ince, C., van Bavel, E., Meijer, J., Leijh, P. C., Ypey, D. L.   +4 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

The Dynamic Role of Breathing and Cellular Membrane Potentials in the Experience of Consciousness [PDF]

, 2017
Understanding the mechanics of consciousness remains one of the most important challenges in modern cognitive science. One key step toward understanding consciousness is to associate unconscious physiological processes with subjective experiences of ...
Cearley, Shannon M., Barnes, Vernon A., Junca, Santiago, Ravinder, Jerath   +3 more
core  

VDAC electronics: 2. A new, anaerobic mechanism of generation of the membrane potentials in mitochondria

, 2014
Mitochondrial hexokinase (HK) and creatine kinase (CK) known to form complexes with a voltage dependent anion channel (VDAC) have been reported to increase cell death resistance under hypoxia/anoxia.
Lemeshko, Victor V.
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Membrane potentials of salivary gland cells of rat

, 1965
Transmembrane electrical potentials were recorded from cells of rat salivary glands in vivo, using microelectrodes. The mean (±se) from 61 impalements of unstimulated submaxillary cells was 28 ± 1.4 mv.
C. A. Schneyer, L. H. Schneyer
core   +1 more source

Zebrafish fast muscle contractions avoid the mammalian requirement for voltage-gated Na+ channels.

PLoS Biology
Fast skeletal muscle fibers from zebrafish share a number of functional properties with mammalian twitch muscle fibers, making this vertebrate a precious model to investigate the pathophysiology of neuromuscular disorders.
Léa Demesmay, Romane Idoux, Christine Berthier, Claire Bernat, Léon Espinosa, Vincent Jacquemond, Frédéric Brunet, Angel Maunier-Mercier, Philippe Lory, Sophie Nicole, Bruno Allard   +10 more
doaj   +1 more source

Impaired thalamic burst firing in fragile X syndrome

Cell Reports
Summary: The thalamus performs a critical role in sensory processing by gating the flow of sensory information to the neocortex and directing sensory-guided behaviors, functions that are disrupted in people with autism spectrum disorder (ASD).
Ronan T. O’Shea, Nicholas J. Priebe, Darrin H. Brager   +2 more
doaj   +1 more source