Results 11 to 20 of about 6,618,097 (286)
Functional characterisation of the lipid raft protein stomatin [PDF]
, 2005 The function of the integral membrane protein stomatin is as yet poorly understood. Stomatin is deficient from the erythrocyte membrane of patients suffering with Overhydrated Hereditary Stomatocytosis (OHSt).
Wilkinson, Dorothy Kate
core +7 more sources
Altered gene expression in slc4a11 −/− mouse cornea highlights SLC4A11 roles
Scientific Reports, 2021 SLC4A11 is a H+/NH3/water transport protein, of corneal endothelial cells. SLC4A11 mutations cause congenital hereditary endothelial dystrophy and some cases of Fuchs endothelial corneal dystrophy. To probe SLC4A11’s roles, we compared gene expression in
Bernardo V. Alvarez +6 more
doaj +1 more source
Allostery in membrane proteins [PDF]
Current Opinion in Structural Biology, 2020 Membrane proteins are an integral part of signal transduction. To signal, membrane proteins must interact with a variety of lipid species, effectors, and other proteins in the biological membrane leading to an immense number of possible interactions. Despite this inherent complexity, accurate control of signaling must take place.
Zoe Cournia, Alexios Chatzigoulas
openaire +3 more sources
Nature Communications, 2022 Developing antibacterial agents which don’t have cytotoxic effects against mammalian cells is of interest for biomedical applications. Here, the authors explore how attaching inert polymer brushes to different sized nanoparticles can result in toxicity ...
Yunjiang Jiang +6 more
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Cells, 2022 The dopamine transporter (DAT) is a member of the neurotransmitter:sodium symporter (NSS) family, mediating the sodium-driven reuptake of dopamine from the extracellular space thereby terminating dopaminergic neurotransmission.
Ciara Frances Pugh +3 more
doaj +1 more source
Changes in Membrane Protein Structural Biology
Biology, 2020 Membrane proteins are essential components of many biochemical processes and are important pharmaceutical targets. Membrane protein structural biology provides the molecular rationale for these biochemical process as well as being a highly useful tool ...
James Birch +5 more
doaj +1 more source
Doa10 is a membrane protein retrotranslocase in ER-associated protein degradation
eLife, 2020 In endoplasmic reticulum-associated protein degradation (ERAD), membrane proteins are ubiquitinated, extracted from the membrane, and degraded by the proteasome. The cytosolic ATPase Cdc48 drives extraction by pulling on polyubiquitinated substrates. How
Claudia C Schmidt +2 more
doaj +1 more source
Heliyon, 2023 In the renal collecting ducts, chloride reabsorption occurs through both transcellular and paracellular pathways. Recent literature highlights a functional interplay between both pathways.
Rawad Lashhab +4 more
doaj +1 more source
MPIase is a glycolipozyme essential for membrane protein integration [PDF]
, 2021 Protein integration into biological membranes is a vital cellular event for all organisms. We previously reported an integration factor in the inner membrane of Escherichia coli, named MPIase (membrane protein integrase). Here we show that in contrast to
IWASHITA, Takashi +9 more
core +2 more sources
The dopamine transporter antiports potassium to increase the uptake of dopamine
Nature Communications, 2022 The dopamine transporter, DAT, controls dopamine signaling by facilitating its reuptake using the Na+ gradient as driving force. Here, the authors uncover that an antiport of K+ ions also contributes to setting the rate of DAT-mediated dopamine clearance.
Solveig G. Schmidt +9 more
doaj +1 more source