Results 271 to 280 of about 3,545,588 (360)

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

The integral membrane protein smim4 modulates redox balance via malate compartmentalization in pancreatic cancer. [PDF]

Nat Commun
Wang B, Han X, Lin X, Wang J, You C, Chen K, Chen Y, Meng F, Jiang H, Zheng F, Zhang Y, Lyu J, Bai Y, Qu X, Zhou D, Jiang M, Cui W, Lyu J, Fang H.   +18 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Development of pXeDNA3.1-LacZ, a Dual-System Plasmid for Membrane Protein Expression in <i>Xenopus</i> and Mammalian Cells. [PDF]

MicroPubl Biol
Guan L, Reynoldson TE, Pieroni EM, Dillon JC, Hardege I, Yanez-Guerra LA.   +5 more
europepmc   +1 more source

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source

Barrel expansion of outer membrane protein G nanopore through β-hairpin duplication. [PDF]

Protein Sci
Foster JC, Pham B, Pham R, Ryan P, Tong N, Sharp J, Inaba-Inoue S, Liang J, Beis K, Chen M.   +9 more
europepmc   +1 more source

Synthetic biology tools for the efficient and functional expression of membrane proteins

, 2020
Chiara Guidi, Lien De Wannemaeker, Jasmine De Baets, Dries Duchi, Jo Maertens, Marjan De Mey   +5 more
openalex   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Identification of the client-binding site on the Golgi membrane protein adaptor Vps74/yGOLPH3. [PDF]

iScience
Lesniak AM, Ye Z, Banfield DK.
europepmc   +1 more source