Results 21 to 30 of about 2,314,591 (317)
Functional implications of the exon 9 splice insert in GluK1 kainate receptors
eLifeKainate receptors are key modulators of synaptic transmission and plasticity in the central nervous system. Different kainate receptor isoforms with distinct spatiotemporal expressions have been identified in the brain.
Surbhi Dhingra +3 more
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Membrane systems with proteins embedded in membranes
Theoretical Computer Science, 2008 Membrane computing is a biologically inspired computational paradigm. Motivated by brane calculi we investigate membrane systems which differ from conventional membrane systems by the following features: (1) biomolecules (proteins) can move through the regions of the systems, and can attach onto (and de-attach from) membranes, and (2) membranes can ...
Brijder R. +4 more
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Inhibition by Commercial Aminoglycosides of Human Connexin Hemichannels Expressed in Bacteria
Molecules, 2017 In addition to gap junctional channels that mediate cell-to-cell communication, connexins form hemichannels that are present at the plasma membrane. Since hemichannels are permeable to small hydrophilic compounds, including metabolites and signaling ...
Mariana C. Fiori +4 more
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An Introduction to Membrane Proteins
Journal of Proteome Research, 2011 α-Helical membrane proteins are important for many biological functions. Due to physicochemical constraints, the structures of membrane proteins differ from the structure of soluble proteins. Historically, membrane protein structures were assumed to be more or less two-dimensional, consisting of long, straight, membrane-spanning parallel helices packed
Hedin, Linnea E. +2 more
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Specific DNA-RNA Hybrid Recognition by TAL Effectors
Cell Reports, 2012 The transcription activator-like (TAL) effector targets specific host promoter through its central DNA-binding domain, which comprises multiple tandem repeats (TALE repeats).
Ping Yin +6 more
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Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication
Nature Communications, 2020 Coronavirus main protease is essential for viral polyprotein processing and replication. Here Vuong et al. report efficient inhibition of SARS-CoV-2 replication by the dipeptide-based protease inhibitor GC376 and its parent GC373, which were originally ...
Wayne Vuong +13 more
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Structure and mechanism of membrane transporters
Scientific Reports, 2022 Membrane transporters are an important group of proteins in physiology and disease. Their functions make them common drug targets, but their location in the lipid bilayers poses a tremendous challenge to researchers.
Lan Guan
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Inhibition of TRPP3 by calmodulin through Ca2+/calmodulin-dependent protein kinase II
Cell Insight, 2023 Transient receptor potential (TRP) polycystin-3 (TRPP3) is a non-selective cation channel activated by Ca2+ and protons and is involved in regulating ciliary Ca2+ concentration, hedgehog signaling and sour tasting.
Xiong Liu +6 more
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Structures of membrane proteins [PDF]
Quarterly Reviews of Biophysics, 2010 AbstractIn reviewing the structures of membrane proteins determined up to the end of 2009, we present in words and pictures the most informative examples from each family. We group the structures together according to their function and architecture to provide an overview of the major principles and variations on the most common themes.
Kutti R. Vinothkumar, Richard Henderson
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Nature Communications, 2020 An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Wayne Vuong +13 more
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