Results 41 to 50 of about 3,087,877 (362)
An Introduction to Membrane Proteins
Journal of Proteome Research, 2011 α-Helical membrane proteins are important for many biological functions. Due to physicochemical constraints, the structures of membrane proteins differ from the structure of soluble proteins. Historically, membrane protein structures were assumed to be more or less two-dimensional, consisting of long, straight, membrane-spanning parallel helices packed
Hedin, Linnea E. +2 more
openaire +5 more sources
Nature Communications, 2020 An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Wayne Vuong +13 more
doaj +1 more source
The rapid developments of membrane protein structure biology over the last two decades
BMC Biology, 2023 Membrane protein research has flourished in the past 20 years. Exciting technological innovations in structural biology, including cryoEM single-particle analysis and AI-based protein structure prediction, such as AlphaFold 2, have largely revolutionized
Lan Guan
doaj +1 more source
Thermodynamic competition between membrane protein oligomeric states
, 2016 Self-assembly of protein monomers into distinct membrane protein oligomers provides a general mechanism for diversity in the molecular architectures, and resulting biological functions, of membrane proteins.
Haselwandter, Christoph A. +1 more
core +1 more source
Structures of membrane proteins [PDF]
Quarterly Reviews of Biophysics, 2010 AbstractIn reviewing the structures of membrane proteins determined up to the end of 2009, we present in words and pictures the most informative examples from each family. We group the structures together according to their function and architecture to provide an overview of the major principles and variations on the most common themes.
Kutti R. Vinothkumar, Richard Henderson
openaire +2 more sources
Conformational dynamics of the human serotonin transporter during substrate and drug binding
Nature Communications, 2019 The serotonin transporter (SERT) is responsible for re-uptake of serotonin into the presynaptic neuron and plays a key role in synaptic transmission. Here, the authors use hydrogen-deuterium exchange mass spectrometry to probe the conformational dynamics
Ingvar R. Möller +6 more
doaj +1 more source
Structural insight into the mechanism of energy transfer in cyanobacterial phycobilisomes
Nature Communications, 2021 The major light-harvesting systems for photosynthesis in cyanobacteria and red algae are phycobilisomes (PBS). Here, the authors present the cryo-EM structures of two cyanobacterial PBS from Anabaena 7120 and Synechococcus 7002 and discuss their energy ...
Lvqin Zheng +7 more
doaj +1 more source
Insertion of proteins into the inner membrane of mitochondria: the role of the Oxa1 complex [PDF]
, 2002 The inner mitochondrial membrane harbors a large number of proteins that display a wide range of topological arrangements. The majority of these proteins are encoded in the cell\u27s nucleus, but a few polytopic proteins, all subunits of respiratory ...
Stuart, Rosemary A.
core +2 more sources
Structural Biology and Structure–Function Relationships of Membrane Proteins
Biology, 2021 To understand the biological complexity of life, one needs to investigate how biomolecules behave and interact with each other at a molecular level [...]
Isabel Moraes, Andrew Quigley
doaj +1 more source
Uni-directional ciliary membrane protein trafficking by a cytoplasmic retrograde IFT motor and ciliary ectosome shedding [PDF]
, 2015 The role of the primary cilium in key signaling pathways depends on dynamic regulation of ciliary membrane protein composition, yet we know little about the motors or membrane events that regulate ciliary membrane protein trafficking in existing ...
Adair +63 more
core +3 more sources