Results 81 to 90 of about 6,618,097 (286)
Structural Biology and Structure–Function Relationships of Membrane Proteins
Biology, 2021 To understand the biological complexity of life, one needs to investigate how biomolecules behave and interact with each other at a molecular level [...]
Isabel Moraes, Andrew Quigley
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FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Scientific Reports, 2017 The resolution of electron-potential maps in single-particle cryo-electron microscopy (cryoEM) is approaching atomic or near- atomic resolution. However, no program currently exists for de novo cryoEM model building at resolutions exceeding beyond 3.5 Å.
Niyun Zhou, Hongwei Wang, Jiawei Wang
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Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Structure and Mechanism of a Nitrate Transporter
Cell Reports, 2013 The nitrate/nitrite transporters NarK and NarU play an important role in nitrogen homeostasis in bacteria and belong to the nitrate/nitrite porter family (NNP) of the major facilitator superfamily (MFS) fold.
Hanchi Yan +7 more
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Membrane proteins in nanotechnology [PDF]
The Biochemist, 2009 The potential for nanotechnology to transform modern life has been appreciated for several years. Generally, nanotechnology involves objects with at least one dimension of less than 100 nm. Such stuff is abundant in the natural world, and one of the most exciting current areas in nanoscience research is the use of proteins as nanoscale components of ...
openaire +3 more sources
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Dynamic insertion of membrane proteins at the endoplasmic reticulum [PDF]
, 2005 Most eukaryotic membrane proteins are cotranslationally integrated into the endoplasmic reticulum membrane by the Sec61 translocation complex. They are targeted to the translocon by hydrophobic signal sequences which induce the translocation of either ...
Higy, Marie
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UBE2J2 sensitizes the ERAD ubiquitination cascade to changes in membrane lipid saturation
Nature CommunicationsProtein–lipid crosstalk is fundamental to homeostasis in the endoplasmic reticulum (ER). The ER-associated degradation (ERAD) pathway, a branch of the ubiquitin–proteasome system, maintains ER membrane properties by degrading lipid metabolic enzymes ...
Aikaterini Vrentzou +4 more
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The gating cycle of a K+ channel at atomic resolution
eLife, 2017 C-type inactivation in potassium channels helps fine-tune long-term channel activity through conformational changes at the selectivity filter. Here, through the use of cross-linked constitutively open constructs, we determined the structures of KcsA’s ...
Luis G Cuello +2 more
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