Results 51 to 60 of about 1,639,954 (343)

Characterization of a Dimeric Arginase From Zymomonas mobilis ZM4

Frontiers in Microbiology, 2019
Many organisms have genes to protect themselves from toxic conditions such as high ethanol and/or ammonia concentrations. When a high ethanol condition is induced to Zymomonas mobilis ZM4, a representative ethanologenic organism, this bacterium ...
Seung-A Hwangbo, Seung-A Hwangbo, Ji-Won Kim, Sun-Ju Jung, Kyeong Sik Jin, Jie-Oh Lee, Jeong-Sun Kim, Suk-Youl Park   +7 more
doaj   +1 more source

Optimized reconstitution of membrane proteins into synthetic membranes [PDF]

Communications Chemistry, 2018
AbstractLight-driven proton pumps, such as proteorhodopsin, have been proposed as an energy source in the field of synthetic biology. Energy is required to power biochemical reactions within artificially created reaction compartments like proto- or nanocells, which are typically based on either lipid or polymer membranes.
Alfredo Di Silvestro, Gesine Gunkel-Grabole, Dimitrios Fotiadis, Wolfgang Meier, Noah Ritzmann, Roland Goers, Roland Goers, Daniel J. Müller, Johannes Thoma, Claudio L. Alter   +9 more
openaire   +5 more sources

Ablation of LRP6 in alpha‐smooth muscle actin‐expressing cells abrogates lung inflammation and fibrosis upon bleomycin‐induced lung injury

FEBS Letters, EarlyView.
Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung, Mikhail G. Dozmorov, SuJeong Song, Theingi Aung, Min Hee Park, Patricia J. Sime, Wook‐Jin Chae   +6 more
wiley   +1 more source

The Bor1 elevator transport cycle is subject to autoinhibition and activation

Nature Communications
Boron, essential for plant growth, necessitates precise regulation due to its potential toxicity. This regulation is achieved by borate transporters (BORs), which are homologous to the SLC4 family.
Yan Jiang, Jiansen Jiang
doaj   +1 more source

Structure and dynamics of semaglutide- and taspoglutide-bound GLP-1R-Gs complexes

Cell Reports, 2021
Summary: The glucagon-like peptide-1 receptor (GLP-1R) regulates insulin secretion, carbohydrate metabolism, and appetite and is an important target for treatment of type 2 diabetes and obesity. Multiple GLP-1R agonists have entered into clinical trials,
Xin Zhang, Matthew J. Belousoff, Yi-Lynn Liang, Radostin Danev, Patrick M. Sexton, Denise Wootten   +5 more
doaj  

Characterisation of IL-23 receptor antagonists and disease relevant mutants using fluorescent probes

Nature Communications, 2023
Association of single nucleotide polymorphisms in the IL-23 receptor with several auto-inflammatory diseases, led to the heterodimeric receptor and its cytokine-ligand IL-23, becoming important drug targets.
Charles S. Lay, Albert Isidro-Llobet, Laura E. Kilpatrick, Peter D. Craggs, Stephen J. Hill   +4 more
doaj   +1 more source

Architecture and Function of Mechanosensitive Membrane Protein Lattices [PDF]

Sci. Rep. 6, 19214 (2016), 2016
Experiments have revealed that membrane proteins can form two-dimensional clusters with regular translational and orientational protein arrangements, which may allow cells to modulate protein function. However, the physical mechanisms yielding supramolecular organization and collective function of membrane proteins remain largely unknown.
arxiv   +1 more source

Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases

FEBS Letters, EarlyView.
The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher, Paula Armina V. Buco, Jia Q. Truong, Paul A. Ramsland, Monique F. Smeets, Carl R. Walkley, Jessica K. Holien   +6 more
wiley   +1 more source

Insertion of the FeB cofactor in cNORs lacking metal inserting chaperones

FEBS Letters, EarlyView.
Nitric oxide reductase is an enzyme found in the bacterial denitrification pathway. The NOR active site contains a non‐heme iron, often, but not always inserted with the assistance of chaperones. Here, we study the insertion of FeB in the subfamily of cNORs lacking chaperones and found a putative channel, conserved in the family, perhaps enabling the ...
Sofia Appelgren, Pia Ädelroth
wiley   +1 more source

Aspergillus fumigatus Infection-Induced Neutrophil Recruitment and Location in the Conducting Airway of Immunocompetent, Neutropenic, and Immunosuppressed Mice

Journal of Immunology Research, 2018
Susceptibility to fungal infection is commonly associated with impaired neutrophil responses. To study the mechanisms underlying this association, we investigated neutrophil recruitment to the conducting airway wall after Aspergillus fumigatus conidium ...
Marina A. Shevchenko, Andrey O. Bogorodskiy, Natalia I. Troyanova, Ekaterina A. Servuli, Elena L. Bolkhovitina, Georg Büldt, Christoph Fahlke, Valentin I. Gordeliy, Thomas Gensch, Valentin I. Borshchevskiy, Alexander M. Sapozhnikov   +10 more
doaj   +1 more source