Results 91 to 100 of about 495,428 (314)

Pathophysiological Role of Caveolae in Hypertension [PDF]

, 2019
Caveolae, flask-shaped cholesterol-, and glycosphingolipid-rich membrane microdomains, contain caveolin 1, 2, 3 and several structural proteins, in particular Cavin 1-4, EHD2, pacsin2, and dynamin 2.
Daumke, Oliver, Gollasch, Maik, Kaßmann, Mario, Lian, Xiaoming, Matthaeus, Claudia   +4 more
core   +2 more sources

Reconstitutions of mitochondrial inner membrane remodeling

Journal of Structural Biology, 2016
Biological membranes exhibit function-related shapes, leading to a plethora of complex and beautiful cell and cell organellar morphologies. Most if not all of these structures have evolved for a particular physiological reason. The shapes of these structures are formed by physical forces that operate on membranes.
Barbot, Mariam, Meinecke, Michael
openaire   +3 more sources

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Less Grease, Please. Phosphatidylethanolamine Is the Only Lipid Required for Replication of a (+)RNA Virus

Viruses, 2015
All positive strand RNA viruses of eukaryotes replicate their genomes in association with membranes. These viruses actively change cellular lipid metabolism to build replication membranes enriched in specific lipids.
George A. Belov
doaj   +1 more source

Developmental regulation of an organelle tether coordinates mitochondrial remodeling in meiosis. [PDF]

, 2018
Cellular differentiation involves remodeling cellular architecture to transform one cell type to another. By investigating mitochondrial dynamics during meiotic differentiation in budding yeast, we sought to understand how organelle morphogenesis is ...
Berchowitz, Luke, Jorgensen, Victoria, Joshi, Pallavi, Sawyer, Eric, Yunus, Julius, Ünal, Elçin   +5 more
core   +2 more sources

Mechanochemical Rules for Shape-Shifting Filaments that Remodel Membranes [PDF]

, 2022
Billie Meadowcroft, Ivan Palaia, Anna-Katharina Pfitzner, Aurélien Roux, Buzz Baum, Anđela Šarić   +5 more
openalex   +1 more source

Membrane lipid remodeling modulates γ-secretase processivity

Journal of Biological Chemistry, 2023
Imbalances in the amounts of amyloid-β peptides (Aβ) generated by the membrane proteases β- and γ-secretase are considered as a trigger of Alzheimer's disease (AD). Cell-free studies of γ-secretase have shown that increasing membrane thickness modulates Aβ generation but it has remained unclear if these effects are translatable to cells.
Edgar Dawkins, Rico J.E. Derks, Martina Schifferer, Johannes Trambauer, Edith Winkler, Mikael Simons, Dominik Paquet, Martin Giera, Frits Kamp, Harald Steiner   +9 more
openaire   +6 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Membrane elongation factors in organelle maintenance: the case of peroxisome proliferation

Biomolecular Concepts, 2011
Separation of metabolic pathways in organelles is critical for eukaryotic life. Accordingly, the number, morphology and function of organelles have to be maintained through processes linked with membrane remodeling events.
Koch Johannes, Brocard Cécile
doaj   +1 more source

Exosomes promote pre-metastatic niche formation in ovarian cancer. [PDF]

, 2019
Ovarian cancer is one of the most common gynecological malignancies. Upon initial diagnosis, the majority of patients present with widespread metastatic growth within the peritoneal cavity. This metastatic growth occurs in stages, with the formation of a
Dean, Dylan C, Duan, Zhenfeng, Feng, Wenlong, Hornicek, Francis J, Shi, Huirong   +4 more
core   +2 more sources