Results 71 to 80 of about 500,253 (300)

An Amphipathic Alpha-Helix Domain from Poliovirus 2C Protein Tubulate Lipid Vesicles

Viruses, 2020
Positive-strand RNA viruses universally remodel host intracellular membranes to form membrane-bound viral replication complexes, where viral offspring RNAs are synthesized.
Jobin Varkey, Jiantao Zhang, Junghyun Kim, Gincy George, Guijuan He, George Belov, Ralf Langen, Xiaofeng Wang   +7 more
doaj   +1 more source

Regulatory Role of Phospholipids in Hepatitis C Virus Replication and Protein Function

Pathogens, 2022
Positive-strand RNA viruses such as hepatitis C virus (HCV) hijack key factors of lipid metabolism of infected cells and extensively modify intracellular membranes to support the viral lifecycle.
Anna V. Bulankina, Rebecca M. Richter, Christoph Welsch   +2 more
doaj   +1 more source

Formin-dependent TGF-β signaling for epithelial to mesenchymal transition. [PDF]

, 2018
The role of distinct actin filament architectures in epithelial plasticity remains incompletely understood. We therefore determined roles for formins and the Arp2/3 complex, which are actin nucleators generating unbranched and branched actin filaments ...
Aloisio, Francesca M, Barber, Diane L, Choi, Changhoon, Rana, Manish K   +3 more
core   +2 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

The meaning of different forms of structural myocardial injury, immune response and timing of infarct necrosis and cardiac repair [PDF]

, 2015
Although a decline in the all-cause and cardiac mortality rates following myocardial infarction (MI) during the past 3 decades has been reported, MI is a major cause of death and disability worldwide.
Bello, S, Fineschi, Vittorio, Neri, M, Pomara, C, Riezzo, I, Turillazzi, E   +5 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Lipid droplets and polyunsaturated fatty acid trafficking: Balancing life and death

Frontiers in Cell and Developmental Biology, 2023
Lipid droplets are fat storage organelles ubiquitously distributed across the eukaryotic kingdom. They have a central role in regulating lipid metabolism and undergo a dynamic turnover of biogenesis and breakdown to meet cellular requirements for fatty ...
Mauro Danielli, Leja Perne, Eva Jarc Jovičić, Toni Petan   +3 more
doaj   +1 more source

Molecularly Engineered Self-Assembling Membranes for Cell-Mediated Degradation [PDF]

, 2015
The use of peptide engineering to develop self-assembling membranes that are responsive to cellular enzyme activities is reported. The membranes are obtained by combining hyaluronan (HA) and a rationally designed peptide amphiphile (PA) containing a ...
Aimes, Almond, Babel, Banerjee, Banerjee, Behanna, Bott, Burdick, Capito, Caponi, Chau, Chen, Clark, Collier, David-Raoudi, Dehsorkhi, Dicker, Ehrbar, Ferreira, Fonseca, Galler, Galler, Giano, Greenfield, Griffith, Hartgerink, Hinz, Jun, Khelfallah, Khetan, Kim, Kim, Koda, Kähäri, Langer, Langholz, Laurent, Lin, Lutolf, Lutolf, Lutolf, López-De León, Martin-Martin, Mendes, Mendes, Nagase, Nolte, Page-McCaw, Patterson, Schmoekel, Shaw, Solis, Takahashi, Toole, Varani, Vu, Webber, Webber, Werb, Werner, Werner, West, Widgerow, Yang, Zelzer, Zisch   +65 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Changes in membrane biophysical properties induced by sphingomyelinase depend on the sphingolipid N-acyl chain

Journal of Lipid Research, 2014
Ceramide (Cer) is involved in the regulation of several cellular processes by mechanisms that depend on Cer-induced changes on membrane biophysical properties.
Sandra N. Pinto, Elad L. Laviad, Johnny Stiban, Samuel L. Kelly, Alfred H. Merrill, Jr., Manuel Prieto, Anthony H. Futerman, Liana C. Silva   +7 more
doaj   +1 more source