Results 91 to 100 of about 500,253 (300)

Membrane lipid remodeling modulates γ-secretase processivity

Journal of Biological Chemistry, 2023
Imbalances in the amounts of amyloid-β peptides (Aβ) generated by the membrane proteases β- and γ-secretase are considered as a trigger of Alzheimer's disease (AD). Cell-free studies of γ-secretase have shown that increasing membrane thickness modulates Aβ generation but it has remained unclear if these effects are translatable to cells.
Edgar Dawkins, Rico J.E. Derks, Martina Schifferer, Johannes Trambauer, Edith Winkler, Mikael Simons, Dominik Paquet, Martin Giera, Frits Kamp, Harald Steiner   +9 more
openaire   +6 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Membrane elongation factors in organelle maintenance: the case of peroxisome proliferation

Biomolecular Concepts, 2011
Separation of metabolic pathways in organelles is critical for eukaryotic life. Accordingly, the number, morphology and function of organelles have to be maintained through processes linked with membrane remodeling events.
Koch Johannes, Brocard Cécile
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Functional Classification of Skeletal Muscle Networks. I. Normal Physiology [PDF]

, 2012
Extensive measurements of the parts list of human skeletal muscle through transcriptomics and other phenotypic assays offer the opportunity to reconstruct detailed functional models.
Subramaniam, Shankar, Wang, Yu, Winters, John   +2 more
core   +2 more sources

Biophysics of α-synuclein induced membrane remodelling [PDF]

Physical Chemistry Chemical Physics, 2015
α-Synuclein leads to thinning, and subsequent tubulation of membrane bilayer.
Zheng, Shi, Jonathan N, Sachs, Elizabeth, Rhoades, Tobias, Baumgart   +3 more
openaire   +2 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Mouse nuclear myosin I knock-out shows interchangeability and redundancy of myosin isoforms in the cell nucleus. [PDF]

, 2013
Nuclear myosin I (NM1) is a nuclear isoform of the well-known "cytoplasmic" Myosin 1c protein (Myo1c). Located on the 11(th) chromosome in mice, NM1 results from an alternative start of transcription of the Myo1c gene adding an extra 16 amino acids at ...
A Bose, A Bose, A Obrdlik, Alexander Bohla, Ali Önder Yildirim, Alžběta Kalendová, AM Sokac, Andre Van Wijnen, B Barylko, Birgit Rathkolb, C Ambrosino, C Zadro, CH Chuang, D Schenten, DN Simon, E Arif, EA Stauffer, Eckhard Wolf, F Aslinia, FS Wang, G Nowak, H Fuchs, Helmut Fuchs, I Grummt, I Ihnatovych, J Ye, Jana Rohožková, K Fulzele, K Kysela, KA McGowan, L Pestic-Dragovich, M Ferron, M Kahle, Martin Hrabě de Angelis, MC Wagner, Michal Kahle, N Fomproix, O Reizes, Oliver Eickelberg, P Leneuve, P Percipalle, Pavel Hozák, PG Gillespie, PG Gillespie, R Dzijak, R Nambiar, Rastislav Dzijak, RE McConnell, Thomas Rülicke, TJ Diefenbach, TN Willig, Tobias Stoeger, Tomáš Venit, V Gailus-Durner, Valérie Gailus-Durner, Volker Schmidt, VV Philimonenko, VV Philimonenko, WA Hofmann, Wolfgang Hans   +59 more
core   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

LPS Remodeling Triggers Formation of Outer Membrane Vesicles in Salmonella

mBio, 2016
Outer membrane vesicles (OMV) are proposed to mediate multiple functions during pathogenesis and symbiosis. However, the mechanisms responsible for OMV formation remain poorly understood.
Wael Elhenawy, Michael Bording-Jorgensen, Ezequiel Valguarnera, M. Florencia Haurat, Eytan Wine, Mario F. Feldman   +5 more
doaj   +1 more source