Emerging Roles of the MICOS Complex in Cristae Dynamics and Biogenesis
Biology, 2021 Mitochondria are double membrane-enclosed organelles performing important cellular and metabolic functions such as ATP generation, heme biogenesis, apoptosis, ROS production and calcium buffering.
Ruchika Anand +2 more
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Cristae: bridging bioenergetic hubs and compartmental barriers in mitochondrial homeostasis [PDF]
Cell Death and DiseaseMitochondrial cristae are intricately folded structures of the inner mitochondrial membrane that play essential roles in cellular energy production, metabolic regulation, and compartmentalization.
Jin Rao +6 more
doaj +2 more sources
Redox Biology, 2021 Reactive oxygen species (ROS) are a common product of active mitochondrial respiration carried in mitochondrial cristae, but whether cristae shape influences ROS levels is unclear.
Israel Manjarres-Raza +2 more
exaly +3 more sources
Atypical Phenotypes of Mitochondrial Cristae Architecture in Selected Human Aging Striated Muscles—Transmission Electron Microscope Studies [PDF]
LifeThe diversity of mitochondria ultrastructure in human aging striated muscles is presented in relation to the complexity and variability of the cristae architecture and in relation to the environment of mitochondrial occurrence in the muscle fiber on the ...
Paulina Felczak
doaj +2 more sources
Src-mediated PHB2 phosphorylation disrupts mitochondrial cristae through cardiolipin dissociation in hepatocellular carcinoma [PDF]
Redox BiologyHepatocellular carcinoma (HCC) displays mitochondrial dysfunction characterized by disrupted redox homeostasis and cristae disorganization, yet the underlying molecular mechanisms are unclear.
Zhehua Shao +6 more
doaj +2 more sources
Mitochondrial cristae remodeling: Mechanisms, functions, and pathology [PDF]
Cell InsightMitochondrial cristae are the principal sites of oxidative phosphorylation and are central to mitochondria-dependent energy metabolism. Rather than static folds, cristae are dynamic bioenergetic compartments that remodel in response to physiological and ...
Jianglong Yu +7 more
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Cardiolipin and mitochondrial cristae organization
Biochimica Et Biophysica Acta - Biomembranes, 2017 A fundamental question in cell biology, under investigation for over six decades, is the structural organization of mitochondrial cristae. Long known to harbor electron transport chain proteins, crista membrane integrity is key to establishment of the proton gradient that drives oxidative phosphorylation. Visualization of cristae morphology by electron
Nikita Ikon, Robert Ryan
exaly +3 more sources
A Universal Approach to Analyzing Transmission Electron Microscopy with ImageJ
Cells, 2021 Transmission electron microscopy (TEM) is widely used as an imaging modality to provide high-resolution details of subcellular components within cells and tissues. Mitochondria and endoplasmic reticulum (ER) are organelles of particular interest to those
Jacob Lam +17 more
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Specific Changes in Morphology and Dynamics of Plant Mitochondria under Abiotic Stress
Horticulturae, 2022 As the global climate continues to warm and the greenhouse effect intensifies, plants are facing various abiotic stresses during their growth and development.
Hui Tang, Hongliang Zhu
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Modeling the Effects of Calcium Overload on Mitochondrial Ultrastructural Remodeling
Applied Sciences, 2021 Mitochondrial cristae are dynamic invaginations of the inner membrane and play a key role in its metabolic capacity to produce ATP. Structural alterations caused by either genetic abnormalities or detrimental environmental factors impede mitochondrial ...
Jasiel O. Strubbe-Rivera +5 more
doaj +1 more source