Results 11 to 20 of about 36,169 (256)
The Functional Impact of Mitochondrial Structure Across Subcellular Scales
Frontiers in Physiology, 2020 Mitochondria are key determinants of cellular health. However, the functional role of mitochondria varies from cell to cell depending on the relative demands for energy distribution, metabolite biosynthesis, and/or signaling.
Brian Glancy +5 more
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Consequences of Folding the Mitochondrial Inner Membrane
Frontiers in Physiology, 2020 A fundamental first step in the evolution of eukaryotes was infolding of the chemiosmotic membrane of the endosymbiont. This allowed the proto-eukaryote to amplify ATP generation while constraining the volume dedicated to energy production.
Carmen A. Mannella
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Mitochondrial Cristae Architecture and Functions: Lessons from Minimal Model Systems
Membranes, 2021 Mitochondria are known as the powerhouse of eukaryotic cells. Energy production occurs in specific dynamic membrane invaginations in the inner mitochondrial membrane called cristae.
Frédéric Joubert, Nicolas Puff
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Mitochondrial Membrane Remodeling
Frontiers in Bioengineering and Biotechnology, 2022 Mitochondria are key regulators of many important cellular processes and their dysfunction has been implicated in a large number of human disorders.
Ziyun Yang +22 more
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Pathways shaping the mitochondrial inner membrane
Open Biology, 2021 Mitochondria are complex organelles with two membranes. Their architecture is determined by characteristic folds of the inner membrane, termed cristae.
Till Klecker, Benedikt Westermann
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Why does a mitochondrion need its individual cristae to be functionally autonomous?
Molecular & Cellular Oncology, 2020 We demonstrated that individual cristae in one mitochondrion function as autonomous electrochemical units, with this autonomy being maintained by cristae junction modulators.
Marc Liesa
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Cells, 2022 CARD19 is a mitochondrial protein of unknown function. While CARD19 was originally reported to regulate TCR-dependent NF-κB activation via interaction with BCL10, this function is not recapitulated ex vivo in primary murine CD8+ T cells.
Kariana E. Rios +6 more
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Mitochondrial Membrane Dynamics—Functional Positioning of OPA1
Antioxidants, 2018 The maintenance of mitochondrial energetics requires the proper regulation of mitochondrial morphology, and vice versa. Mitochondrial dynamins control mitochondrial morphology by mediating fission and fusion.
Hakjoo Lee, Yisang Yoon
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Current Issues in Molecular Biology, 2023 Mitochondria in mammalian cardiomyocytes display considerable structural heterogeneity, the significance of which is not currently understood. We use electron microscopic tomography to analyze a dataset of 68 mitochondrial subvolumes to look for ...
Raquel A. Adams +6 more
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Microbial Cell, 2017 Oxidative phosphorylation takes place at specialized compartments of the inner mitochondrial membrane, the cristae. The elaborate ultrastructure of cristae membranes enables efficient chemi-osmotic coupling of respiratory chain and F1Fo-ATP synthase ...
Heike Rampelt, Martin van der Laan
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