Results 1 to 10 of about 5,312 (162)

Cardiolipin and the Nlrp3 Inflammasome [PDF]

Cell Metabolism, 2013
The Nlrp3 inflammasome is a key controller of the proinflammatory cytokine IL-1β. Iyer and colleagues (2013) demonstrate that Nlrp3 activators promote an interaction between cardiolipin in mitochondria and Nlrp3. Cardiolipin is thus a hydrophobic danger signal that, upon translocation to the outer mitochondrial membrane, activates Nlrp3, promoting ...
O’Neill, Luke A.J., O\u27NEILL, LUKE
openaire   +4 more sources

Ionization Constants pKa of Cardiolipin

PLoS ONE, 2013
Cardiolipin is a phospholipid found in the inner mitochondrial membrane and in bacteria, and it is associated with many physiological functions. Cardiolipin has a dimeric structure consisting of two phosphatidyl residues connected by a glycerol bridge and four acyl chains, and therefore it can carry two negative charges. The pKa values of the phosphate
Gerd Olofsson, Emma Sparr
core   +6 more sources

The cardiolipin analogues of Archaea

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2009
The present article reviews studies of the structure and functional roles of the cardiolipin analogues of extremely halophilic prokaryotes belonging to the Archaea domain. Analogies and differences between the archaeal bisphosphatidylglycerol and the mitochondrial cardiolipin are presented. Furthermore the structure of archaeal glycophospholipid dimers
CORCELLI, Angela
openaire   +5 more sources

StaR-related lipid transfer-like domain-containing protein CLDP43 affects cardiolipin synthesis and mitochondrial function in Trypanosoma brucei. [PDF]

, 2022
Cardiolipin is known to interact with bacterial and mitochondrial proteins and protein complexes. Unlike in Escherichia coli and Saccharomyces cerevisiae, the synthesis of cardiolipin is essential for growth of Trypanosoma brucei parasites in culture ...
Bütikofer, Peter, Loffreda, Alessio, Schlame, Michael   +2 more
core   +1 more source

Cardiolipin-Targeted NIR-II Fluorophore Causes “Avalanche Effects” for Re-Engaging Cancer Apoptosis and Inhibiting Metastasis

, 2022
Restoring innate apoptosis and simultaneously inhibiting metastasis by a molecular drug is an effective cancer therapeutic approach. Herein, a large rigid and V-shaped NIR-II dye, DUT850, is rationally designed for potential cardiolipin (CL)-targeted ...
Dandan Ma (561251), Xiaodong Zhang (183379), Xiaojun Peng (721101), Youjun Yang (1409404), Kai Xin (5782271), Fei Pan (255667), Hui Bian (4849063), Xinfu Zhang (1548433), Yi Xiao (135101)   +8 more
core   +2 more sources

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source

Cardiolipin stabilizes respiratory chain supercomplexes

, 2021
Cardiolipin stabilized supercomplexes of Saccharomyces cerevisiae respiratory chain complexes III and IV (ubiquinol:cytochrome c oxidoreductase and cytochrome c oxidase, respectively), but was not essential for their formation in the inner mitochondrial ...
Hunte, Carola, Pfeiffer, Kathy, Gohil, Vishal, Stuart, Rosemary A., Brandt, Ulrich, Greenberg, Miriam L., Schägger, Hermann   +6 more
core   +2 more sources

Cardiolipin-Mediated Alleviation of Mitochondrial Dysfunction Is a Neuroprotective Effect of Statin in Animal Model of Ischemic Stroke

, 2023
In clinical settings, the benefit of statin for stroke is debatable as regular statin users may suffer from myalgia, statin-associated myopathy (SAM), and rarely rhabdomyolysis.
Swapnil Raut, Abhishek Sarkar, Bijoyani Ghosh (14516139), Pallab Bhattacharya (453692), Nikita Rana (14516142), Vrushali Thongire, Anupom Borah, Deepaneeta Sarmah (6898931), Swapnil Raut (14516157), Deepaneeta Sarmah, Pallab Bhattacharya, Aishika Datta (11462010), Bijoyani Ghosh, Namrata Vadak, Aishika Datta, Upasna Singh (14516160), Namrata Vadak (14516154), Antra Chaudhary, Shubhrakanta Sahu, Upasna Singh, Vishal Gupta, Shubhrakanta Sahu (14516145), Vishal Gupta (763297), Abhishek Sarkar (2941962), Anupom Borah (3723307), Nikita Rana, Harpreet Kaur, Harpreet Kaur (107427), Vrushali Thongire (14516148), Antra Chaudhary (14516151)   +29 more
core   +1 more source

Cross-species complementation of bacterial- and eukaryotic-type cardiolipin synthases [PDF]

, 2017
The glycerophospholipid cardiolipin is a unique constituent of bacterial and mitochondrial membranes. It is involved in forming and stabilizing high molecular mass membrane protein complexes and in maintaining membrane architecture.
Gottier, Petra, Peter Buetikofer, Petra Gottier, Vitale, Rita, Bütikofer, Peter, Corcelli, Angela, Mauro Serricchio, Angela Corcelli, Buetikofer, Peter, Peter Bütikofer, Rita Vitale, Serricchio, Mauro   +11 more
core   +1 more source

Cardiolipin Interactions with Proteins [PDF]

Biophysical Journal, 2015
Cardiolipins (CL) represent unique phospholipids of bacteria and eukaryotic mitochondria with four acyl chains and two phosphate groups that have been implicated in numerous functions from energy metabolism to apoptosis. Many proteins are known to interact with CL, and several cocrystal structures of protein-CL complexes exist.
Planas-Iglesias, Joan, Dwarakanath, Himal, Mohammadyani, Dariush, Yanamala, Naveena, Kagan, Valerian E., Klein-Seetharaman, Judith   +5 more
openaire   +2 more sources