Results 1 to 10 of about 3,234 (169)

Malassezia globosa lipidome: The dynamics of uptake and secreted lipids [PDF]

Virulence
Malassezia globosa plays a crucial role as part of the human skin’s mycobiome. However, this yeast has been detected in other niches, such as the gut.
Catherine Eliana Cabrera Díaz, Mónica P. Cala, Elizabeth Jiménez-Díaz, Adriana Marcela Celis Ramírez   +3 more
doaj   +2 more sources

Phospholipid Acyl Chain Diversity Controls the Tissue-Specific Assembly of Mitochondrial Cardiolipins

Cell Reports, 2020
Summary: Cardiolipin (CL) is a phospholipid specific for mitochondrial membranes and crucial for many core tasks of this organelle. Its acyl chain configurations are tissue specific, functionally important, and generated via post-biosynthetic remodeling.
Gregor Oemer, Jakob Koch, Yvonne Wohlfarter   +2 more
exaly   +3 more sources

The lipidome of the kidney tubules of ob/ob mice is affected at the infralesional level [PDF]

Cell Death Discovery
Whether changes in tubular lipidomic composition precede the onset of observable kidney damage in obesity is unknown. We manually isolated the proximal convoluted tubule (PCT), the cortical thick ascending limb of Henle’s loop (cTAL) and the cortical ...
Lydie Cheval, Julio L. Sampaio, Virginie Poindessous, Gilles Crambert, Nicolas Pallet   +4 more
doaj   +2 more sources

Characteristics, clinical outcomes and molecular mechanisms associated with severe diastolic dysfunction in aortic stenosis [PDF]

Journal of Molecular and Cellular Cardiology Plus
Objectives: We aimed to better understand patient characteristics and pathophysiological mechanisms associated with severe diastolic dysfunction in aortic stenosis patients undergoing transcatheter aortic valve implantation (TAVI).
Kyriakos Panaou, Constantijn S. Venema, Kees H. van Bergeijk, Demetra Hadjicharalambous, Nicolas Girerd, Teresa Trenkwalder, Michael Joner, Pim van der Harst, Jasper Tromp, Adriaan A. Voors, Joanna J. Wykrzykowska   +10 more
doaj   +2 more sources

Cardiolipin acyl chain composition tailors the conformation of mammalian ATP synthase dimers [PDF]

Communications Chemistry
The interplay between ATP synthase dimers and the four-tailed lipid cardiolipin (CL) shapes mitochondrial cristae structure and function. In the mitochondrial disorder Barth syndrome (BTHS), cristae membranes accumulate a less unsaturated, three-tailed ...
M. Makowski, V. G. Almendro-Vedia, I. López-Montero   +2 more
doaj   +2 more sources

Diagnostic Value of Menstrual Blood Lipidomics in Endometriosis: A Pilot Study [PDF]

Biomolecules
Endometriosis is a prevalent chronic inflammatory disease characterized by a considerable delay between initial symptoms and diagnosis through surgery.
Natalia Starodubtseva, Vitaliy Chagovets, Alisa Tokareva, Madina Dumanovskaya, Eugenii Kukaev, Anastasia Novoselova, Vladimir Frankevich, Stanislav V. Pavlovich, Gennady Sukhikh   +8 more
doaj   +2 more sources

Mono- to tetra-alkyl ether cardiolipins in a mesophilic, sulfate-reducing bacterium identified by UHPLC-HRMSn: a novel class of membrane lipids [PDF]

Frontiers in Microbiology
The composition of membrane lipids varies in a number of ways as adjustment to growth conditions. Variations in head group composition and carbon skeleton and degree of unsaturation of glycerol-bound acyl or alkyl chains results in a high structural ...
Ellen C. Hopmans, Vincent Grossi, Diana X. Sahonero-Canavesi, Nicole J. Bale, Cristiana Cravo-Laureau, Jaap S. Sinninghe Damsté, Jaap S. Sinninghe Damsté   +6 more
doaj   +2 more sources

Lipidome Atlas of the Developing Heart Uncovers Dynamic Membrane Lipid Attributes Underlying Cardiac Structural and Metabolic Maturation

Research, 2022
Precise metabolic rewiring during heart organogenesis underlies normal cardiac development. Herein, we utilized high-coverage, quantitative lipidomic approaches to construct lipidomic atlases of whole hearts (861 lipids; 31 classes) and mitochondria (587
Huan Miao, Bowen Li, Zehua Wang, Jinming Mu, Yanlin Tian, Binhua Jiang, Shaohua Zhang, Xia Gong, Guanghou Shui, Sin Man Lam   +9 more
doaj   +1 more source

Cardiolipin drives the catalytic activity of GPX4 on membranes: Insights from the R152H mutant

Redox Biology, 2023
The aim of this study was to examine, in biochemical detail, the functional role of the Arg152 residue in the selenoprotein Glutathione Peroxidase 4 (GPX4), whose mutation to His is involved in Sedaghatian-type Spondylometaphyseal Dysplasia (SSMD).
Antonella Roveri, Flavio Di Giacinto, Monica Rossetto, Giorgio Cozza, Qing Cheng, Giovanni Miotto, Lucio Zennaro, Maria Luisa Di Paolo, Elias S.J. Arnér, Marco De Spirito, Matilde Maiorino, Fulvio Ursini   +11 more
doaj   +1 more source

Role of cardiolipins, mitochondria, and autophagy in the differentiation process activated by all-trans retinoic acid in acute promyelocytic leukemia

Cell Death and Disease, 2022
The role played by lipids in the process of granulocytic differentiation activated by all-trans retinoic acid (ATRA) in Acute-Promyelocytic-Leukemia (APL) blasts is unknown.
Maurizio Gianni’, Laura Goracci, Anna Schlaefli, Alessandra Di Veroli, Mami Kurosaki, Luca Guarrera, Marco Bolis, Marika Foglia, Monica Lupi, Mario P. Tschan, Gabriele Cruciani, Mineko Terao, Enrico Garattini   +12 more
doaj   +1 more source