Results 41 to 50 of about 4,826 (241)
Antioxidants, 2021 Nonalcoholic steatohepatitis (NASH) is a prevalent disease related to lipid metabolism disorder and oxidative stress. Lipid hydroperoxidation is known to be a critical driving force of various disorders and diseases.
Yue Wu +8 more
doaj +1 more source
Differentiating signals to make biological sense – a guide through databases for MS-based non-targeted metabolomics [PDF]
, 2017 Metabolite identification is one of the most challenging steps in metabolomics studies and reflects one of the greatest bottlenecks in the entire workflow.
Armitage, Emily Grace +4 more
core +1 more source
Mouse mitochondrial lipid composition is defined by age in brain and muscle [PDF]
, 2017 Functionality of the lipid rich mitochondrial organelle declines with increased age. Recent advances in lipidomic technologies allowed us to perform a global characterisation of lipid composition in two different tissue types and age ranges.
Al-Gubory +41 more
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Diminished exercise capacity and mitochondrial bc1 complex deficiency in tafazzin-knockdown mice.
Frontiers in Physiology, 2013 The phospholipid, cardiolipin, is essential for maintaining mitochondrial structure and optimal function. Cardiolipin-deficiency in humans, Barth syndrome, is characterized by exercise intolerance, dilated cardiomyopathy, neutropenia and 3-methyl ...
Corey ePowers +3 more
doaj +1 more source
Sphingolipids in human synovial fluid : a lipidomic study [PDF]
, 2014 Articular synovial fluid (SF) is a complex mixture of components that regulate nutrition, communication, shock absorption, and lubrication. Alterations in its composition can be pathogenic. This lipidomic investigation aims to quantify the composition of
Kaesser, Ulrich +10 more
core +3 more sources
Structure of a mitochondrial ATP synthase with bound native cardiolipin
eLife, 2019 The mitochondrial ATP synthase fuels eukaryotic cells with chemical energy. Here we report the cryo-EM structure of a divergent ATP synthase dimer from mitochondria of Euglena gracilis, a member of the phylum Euglenozoa that also includes human parasites.
Alexander Mühleip +2 more
doaj +1 more source
Metabolomic Profiling in the Characterization of Degenerative Bone and Joint Diseases
Metabolites, 2020 Osteoarthritis and inflammatory arthropathies are a cause of significant morbidity globally. New research elucidating the metabolic derangements associated with a variety of bone and joint disorders implicates various local and systemic metabolites ...
Katherine R. Swank +5 more
doaj +1 more source
, 1999 We propose a 2-d computational model-system comprising a mixture of spheres and the objects of some other shapes, interacting via the Lennard-Jones potential. We propose a reliable and efficient numerical algorithm to obtain void statistics.
Gangal, Anil D. +3 more
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RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu +21 more
wiley +1 more source
Crosstalk between the lipopolysaccharide and phospholipid pathways during outer membrane biogenesis in Escherichia coli [PDF]
, 2016 The outer membrane of gram-negative bacteria is composed of phospholipids in the inner leaflet and lipopolysaccharides (LPS) in the outer leaflet. LPS is an endotoxin that elicits a strong immune response from humans, and its biosynthesis is in part ...
Andrews, SS +3 more
core +1 more source