Results 11 to 20 of about 3,383 (226)
Cell Reports, 2020 Summary: Cardiolipin (CL) is a phospholipid specific for mitochondrial membranes and crucial for many core tasks of this organelle. Its acyl chain configurations are tissue specific, functionally important, and generated via post-biosynthetic remodeling.
Markus Haltmeier +2 more
exaly +3 more sources
Cardiolipins and biomembrane function [PDF]
BBA - Biomembranes, 1992 Evidence is discussed for roles of cardiolipins in oxidative phosphorylation mechanisms that regulate State 4 respiration by returning ejected protons across and over bacterial and mitochondrial membrane phospholipids, and that regulate State 3 respiration through the relative contributions of proteins that transport protons, electrons and/or ...
F L Hoch, Frédéric L Hoch
exaly +4 more sources
Characteristics, clinical outcomes and molecular mechanisms associated with severe diastolic dysfunction in aortic stenosis [PDF]
Journal of Molecular and Cellular Cardiology PlusObjectives: We aimed to better understand patient characteristics and pathophysiological mechanisms associated with severe diastolic dysfunction in aortic stenosis patients undergoing transcatheter aortic valve implantation (TAVI).
Kyriakos Panaou +10 more
doaj +2 more sources
Ionization constants pKa of cardiolipin. [PDF]
PLoS ONE, 2013 Cardiolipin is a phospholipid found in the inner mitochondrial membrane and in bacteria, and it is associated with many physiological functions. Cardiolipin has a dimeric structure consisting of two phosphatidyl residues connected by a glycerol bridge ...
Gerd Olofsson, Emma Sparr
doaj +4 more sources
Cardiolipin acyl chain composition tailors the conformation of mammalian ATP synthase dimers [PDF]
Communications ChemistryThe interplay between ATP synthase dimers and the four-tailed lipid cardiolipin (CL) shapes mitochondrial cristae structure and function. In the mitochondrial disorder Barth syndrome (BTHS), cristae membranes accumulate a less unsaturated, three-tailed ...
M. Makowski +2 more
doaj +2 more sources
Diagnostic Value of Menstrual Blood Lipidomics in Endometriosis: A Pilot Study [PDF]
BiomoleculesEndometriosis is a prevalent chronic inflammatory disease characterized by a considerable delay between initial symptoms and diagnosis through surgery.
Natalia Starodubtseva +8 more
doaj +2 more sources
Research, 2022 Precise metabolic rewiring during heart organogenesis underlies normal cardiac development. Herein, we utilized high-coverage, quantitative lipidomic approaches to construct lipidomic atlases of whole hearts (861 lipids; 31 classes) and mitochondria (587
Huan Miao +9 more
doaj +1 more source
Cardiolipin drives the catalytic activity of GPX4 on membranes: Insights from the R152H mutant
Redox Biology, 2023 The aim of this study was to examine, in biochemical detail, the functional role of the Arg152 residue in the selenoprotein Glutathione Peroxidase 4 (GPX4), whose mutation to His is involved in Sedaghatian-type Spondylometaphyseal Dysplasia (SSMD).
Antonella Roveri +11 more
doaj +1 more source
Cell Death and Disease, 2022 The role played by lipids in the process of granulocytic differentiation activated by all-trans retinoic acid (ATRA) in Acute-Promyelocytic-Leukemia (APL) blasts is unknown.
Maurizio Gianni’ +12 more
doaj +1 more source
Different Lipid Signature in Fibroblasts of Long-Chain Fatty Acid Oxidation Disorders
Cells, 2021 Long-chain fatty acid oxidation disorders (lc-FAOD) are a group of diseases affecting the degradation of long-chain fatty acids. In order to investigate the disease specific alterations of the cellular lipidome, we performed undirected lipidomics in ...
Khaled I. Alatibi +8 more
doaj +1 more source