Results 21 to 30 of about 66,906 (291)

Cytochrome c Interaction with Cardiolipin Plays a Key Role in Cell Apoptosis: Implications for Human Diseases

Symmetry, 2022
In the cell cytochrome, c performs different functions depending on the environment in which it acts; therefore, it has been classified as a multifunction protein.
L. Fiorucci, F. Erba, R. Santucci, F. Sinibaldi   +3 more
semanticscholar   +1 more source

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source

Cardiolipin Remodeling by ALCAT1 Links Hypoxia to Coronary Artery Disease by Promoting Mitochondrial Dysfunction.

Molecular Therapy, 2021
Cardiolipin is a mitochondrial signature phospholipid that plays a pivotal role in maintaining cardiac health. A loss of tetralinoleoyl cardiolipin (TLCL), the predominant cardiolipin species in the healthy mammalian heart, is implicated in the ...
Dandan Jia, Jun Zhang, Jian-Yun Nie, John-Paul Andersen, Samantha Réndon, Yue Zheng, Xueling Liu, Zhenjun Tian, Yuguang Shi   +8 more
semanticscholar   +1 more source

Cardiolipin remodeling enables protein crowding in the inner mitochondrial membrane

EMBO Journal, 2021
Mitochondrial cristae are extraordinarily crowded with proteins, which puts stress on the bilayer organization of lipids. We tested the hypothesis that the high concentration of proteins drives the tafazzin‐catalyzed remodeling of fatty acids in ...
Yang Xu, H. Erdjument‐Bromage, Colin K. L. Phoon, T. Neubert, Mindong Ren, M. Schlame   +5 more
semanticscholar   +1 more source

Defining functional classes of Barth syndrome mutation in humans [PDF]

, 2016
The X-linked disease Barth syndrome (BTHS) is caused by mutations in TAZ; TAZ is the main determinant of the final acyl chain composition of the mitochondrial-specific phospholipid, cardiolipin.
Claypool, Steven M., Galbraith, Laura, Gottlieb, Eyal, Herndon, Jenny, Koehler, Carla M., Lu, Ya-Lin, Lu, Ya-Wen, Luyf, Angela, McCaffery, J.Michael, Pras-Raves, Mia, Van Kampen, Antoine, Vaz, Frederic M., Vervaart, Martin   +12 more
core   +8 more sources

Cardiolipin in Immune Signaling and Cell Death.

Trends in Cell Biology, 2020
Cardiolipin (CL) is a tetra-acylated diphosphatidylglycerol lipid. In physiological conditions, CL presents unsaturated chains and is located in the inner mitochondria membrane (IMM).
Malvina Pizzuto, P. Pelegrín
semanticscholar   +1 more source

Cardiolipin Remodeling Defects Impair Mitochondrial Architecture and Function in a Murine Model of Barth Syndrome Cardiomyopathy

Circulation: Heart Failure, 2021
Supplemental Digital Content is available in the text. Background: Cardiomyopathy is a major clinical feature in Barth syndrome (BTHS), an X-linked mitochondrial lipid disorder caused by mutations in Tafazzin (TAZ), encoding a mitochondrial ...
Siting Zhu, Ze'e Chen, Mason Zhu, Ying Shen, Leonardo J. Leon, L. Chi, S. Spinozzi, Changming Tan, Yusu Gu, A. Nguyen, Yi Zhou, Wei Feng, F. Vaz, Xiaohong Wang, Å. Gustafsson, S. Evans, Ouyang Kunfu, Xi Fang   +17 more
semanticscholar   +1 more source

CDP-Diacylglycerol Synthases (CDS): Gateway to Phosphatidylinositol and Cardiolipin Synthesis

Frontiers in Cell and Developmental Biology, 2020
Cytidine diphosphate diacylglycerol (CDP-DAG) is a key intermediate in the synthesis of phosphatidylinositol (PI) and cardiolipin (CL). Both PI and CL have highly specialized roles in cells.
Nicholas J. Blunsom, S. Cockcroft
semanticscholar   +1 more source

Cardiolipin content controls mitochondrial coupling and energetic efficiency in muscle

Science Advances, 2021
Decreasing mitochondrial energy-production efficiency in skeletal muscle can confer protection against diet-induced obesity. Unbalanced energy partitioning participates in the rise of obesity, a major public health concern in many countries.
A. Prola, J. Blondelle, Aymeline Vandestienne, J. Piquereau, R. Denis, S. Guyot, Hadrien Chauvin, Arnaud Mourier, M. Maurer, C. Henry, Nahed Khadhraoui, Cindy Gallerne, T. Molinié, Guillaume Courtin, Laurent Guillaud, Mélanie Gressette, A. Solgadi, F. Dumont, J. Castel, J. Ternacle, J. Demarquoy, A. Malgoyre, N. Koulmann, G. Derumeaux, M. Giraud, F. Joubert, V. Veksler, S. Luquet, F. Relaix, L. Tiret, Fanny Pilot-Storck   +30 more
semanticscholar   +1 more source

Absence of Cardiolipin From the Outer Leaflet of a Mitochondrial Inner Membrane Mimic Restricts Opa1-Mediated Fusion

Frontiers in Molecular Biosciences, 2021
Cardiolipin is a tetra-acylated di-phosphatidylglycerol lipid enriched in the matrix-facing (inner) leaflet of the mitochondrial inner membrane. Cardiolipin plays an important role in regulating mitochondria function and dynamics.
Yifan Ge, Yifan Ge, Sivakumar Boopathy, Sivakumar Boopathy, Tran H. Nguyen, Tran H. Nguyen, Camila Makhlouta Lugo, Camila Makhlouta Lugo, Luke H. Chao, Luke H. Chao   +9 more
doaj   +1 more source