Results 21 to 30 of about 5,312 (162)

A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity

Advanced Science, EarlyView.
This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu, Xinyu Sun, Wanxia Ma, Jianming Yang, Xuan Sun, Lisong Zhang, Yumeng Liu, Tianshu Ren, Qi Wang, Jingyu Wang, Xiao Li, Xianping Peng, Liu Yang, Junqiang Lv, Zhi Yao, Zhi‐Song Zhang, Quan Wang   +16 more
wiley   +1 more source

Cardiolipins and biomembrane function [PDF]

Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 1992
Evidence is discussed for roles of cardiolipins in oxidative phosphorylation mechanisms that regulate State 4 respiration by returning ejected protons across and over bacterial and mitochondrial membrane phospholipids, and that regulate State 3 respiration through the relative contributions of proteins that transport protons, electrons and/or ...
openaire   +3 more sources

Disruption of Treg Homeostasis in Rheumatoid Arthritis via Ferroptosis‐Mediated ETC Collapse and TXK‐STAT3/PLCγ1 Activation

Advanced Science, EarlyView.
In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen, Xiao Guan, Kexu Xiong, Xiaoyi Shi, Luyao Wu, Chuanxin Su, Jun Zhao, Rongzhen Liang, Huimin Wang, Junlong Dang, Ye Chen, Yiding Xiong, Chi Zhou, Futao Zhao, Zhenhang Zhu, Xiaoli Fan, Li Zhou, Nancy Olsen, Yutong Jiang, Song Guo Zheng   +19 more
wiley   +1 more source

MiR‐940 Suppresses Ferroptosis by Controlling Expression of Key Regulatory Genes

Advanced Science, EarlyView.
A CRISPR‐based screening identified miR‐940 as a critical suppressor of ferroptosis in cancer. By coordinating the downregulation of pro‐ferroptotic genes with the upregulation of GPX4, miR‐940 establishes a regulatory network that protects against ferroptosis and correlates with poor clinical outcomes in distinct cancer entities.
Andrea Kolak, Juliane Tschuck, Stefanie A. I. Weiß, Daniel Kaemena, Karolin Klimm, Ana Galhoz, Larissa Ringelstetter, Myles Fennell, Juliane Merl‐Pham, Anna Artati, Stefanie Strasser, Ralph Garippa, Michael Witting, Hans Zischka, Joel A. Schick, Stefanie M. Hauck, Michael P. Menden, Michelle Vincendeau, Brent R. Stockwell, Kamyar Hadian   +19 more
wiley   +1 more source

Targeting Lipopolysaccharide Transport Induces Membrane Lipid Remodeling and Sensitizes Acinetobacter baumannii to Colistin Treatment

Advanced Science, EarlyView.
This study identifies C4 as a lead inhibitor of the Lpt system. Notably, C4 potentiates colistin activity by disrupting LPS transport and remodeling phospholipid homeostasis, revealing a functional interplay between the Lpt and Mla systems. These findings establish a mechanistic link between Lpt inhibition and membrane lipid remodeling, positioning Lpt–
Jianya Luo, Hetianzi Zhang, Jinju Cai, Shuang Zhou, Haijie Zhang, Zhiqiang Wang, Yuan Liu   +6 more
wiley   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Cardiolipin depletion-induced changes in the Trypanosoma brucei proteome.

, 2019
The mitochondrial signature glycerophospholipid, cardiolipin (CL), binds to transporters of the inner mitochondrial membrane and plays a central role in formation and stability of respiratory supercomplexes.
Graumann, J., Ben Hamidane, H., Gluenz, E, Schadeli, D., Andrew Hemphill, Schädeli, David, Schädeli, David Lukas, Hisham Ben Hamidane, Hemphill, Andrew, Loffreda, A., David Schädeli, Serricchio, Mauro, Serricchio, M., Eva Gluenz, Bütikofer, Peter, Serricchio, M, Peter Bütikofer, Loffreda, A, Gluenz, E., Hemphill, A., Gluenz, Eva, Graumann, J, Loffreda, Alessio, Hemphill, A, Tom Beneke, Beneke, Tom, Bütikofer, P, Schädeli, D, Alessio Loffreda, Johannes Graumann, Ben Hamidane, Hisham, Beneke, T, Mauro Serricchio, Graumann, Johannes, Ben Hamidane, H, Butikofer, P., Beneke, T.   +36 more
core   +1 more source

Evaluation of the Application of Urea Dissociation Treatment to Reduce the False‐Positive Rate of ELISA for Syphilis Detection

Journal of Clinical Laboratory Analysis, EarlyView.
Exploring the application of urea dissociation treatment to reduce the false‐positive rate of ELISA for syphilis detection. From January 2023 to January 2024, seven false‐positive syphilis samples were collected from Xi'an Regional Medical Laboratory Centre as the experimental group, five positive specimens as the control group, and five negative ...
Jiao Wang, Bin Li, Haodi Li, Xucai Dong
wiley   +1 more source

Synthetic Approaches to Cardiolipin Analogs [PDF]

, 2020
The first portion of this document describes the synthesis of three examples of the mitochondrial phospholipid cardiolipin with different fatty acid chain lengths and degrees of unsaturation.
Frasso, Michael
core  

Preliminary Evaluation of a Novel Lupus Anticoagulant Activity Assay Unaffected by Anticoagulants

Journal of Clinical Laboratory Analysis, EarlyView.
A novel one‐step lupus anticoagulant (LA) assay based on the LA‐sensitivity ratio (LA‐SR) was developed to simplify diagnostic testing and reduce potential interference from anticoagulants. The LA‐SR method showed good agreement with guideline‐based LA testing (dRVVT and/or LA‐sensitive APTT) for the detection of LA and demonstrated limited influence ...
Ayu Hidaka, Risa Kaneshige, Seika Nakamura, Yukari Motoki, Junzo Nojima   +4 more
wiley   +1 more source