Results 11 to 20 of about 31,658 (214)

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

open access: yesHepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario   +12 more
wiley   +1 more source

Thematic Review Series: Glycerolipids. Cardiolipin synthesis for the assembly of bacterial and mitochondrial membranes*

open access: yesJournal of Lipid Research, 2008
In this article, the formation of prokaryotic and eukaryotic cardiolipin is reviewed in light of its biological function. I begin with a detailed account of the structure of cardiolipin, its stereochemistry, and the resulting physical properties, and I ...
Michael Schlame
doaj   +1 more source

Cardiolipin Interactions with Proteins [PDF]

open access: yesBiophysical Journal, 2015
Cardiolipins (CL) represent unique phospholipids of bacteria and eukaryotic mitochondria with four acyl chains and two phosphate groups that have been implicated in numerous functions from energy metabolism to apoptosis. Many proteins are known to interact with CL, and several cocrystal structures of protein-CL complexes exist.
Planas-Iglesias, Joan   +5 more
openaire   +2 more sources

Structure of Cardiolipin [PDF]

open access: yesNature, 1958
PANGBORN1 considered that the glycerylglycero-phosphate skeleton of cardiolipin contained three phosphoric acid and four glycerol residues (I), the six available hydroxyl groups in this structure being esterified with unsaturated fatty acids in the intact phospholipid.
openaire   +2 more sources

Cardiolipin Strongly Inhibits the Leakage Activity of the Short Antimicrobial Peptide ATRA-1 in Comparison to LL-37, in Model Membranes Mimicking the Lipid Composition of Staphylococcus aureus

open access: yesMembranes, 2023
Cardiolipin is one of the main phospholipid components of Staphylococcus aureus membranes. This lipid is found at varying concentrations in the bilayer, depending on the growth stage of the bacteria, and as a response to environmental stress. Cardiolipin
Nathalia Calderón-Rivera   +5 more
doaj   +1 more source

Separation and characterization of cardiolipin molecular species by reverse-phase ion pair high-performance liquid chromatography-mass spectrometry1

open access: yesJournal of Lipid Research, 2010
An improved high-performance liquid chromatography-mass spectrometry method for the separation and characterization of cardiolipin molecular species is presented.
Paul E. Minkler, Charles L. Hoppel
doaj   +1 more source

Measuring cardiolipin antibodies [PDF]

open access: yesBMJ, 1995
EDITOR,—Cardiolipin antibodies have been variously cited as a risk factor for cerebral thrombosis1 2 or splanchnic venous thrombosis,3 or as an epiphenomenon loosely associated with vascular disease.4 Cardiolipin antibodies seem to represent a family of low affinity antibodies which share a limited ability to bind to bovine cardiolipin.
A M, Ward, P A, White
openaire   +2 more sources

Cardiolipin exposure on the outer mitochondrial membrane modulates α-synuclein

open access: yesNature Communications, 2018
Cardiolipin is a phospholipid component of the inner mitochondrial membrane. Here the authors demonstrate that cardiolipin interacts with mutant α-synuclein, and that impaired cardiolipin function can lead to spread of α-synuclein between neurons.
Tammy Ryan   +10 more
doaj   +1 more source

Clarifying the Roles of Cardiolipin [PDF]

open access: yesBiophysical Journal, 2014
Cardiolipins (CL) are uniquely structured double lipids that are universally found in membranes which couple electron transport and phosphorylation. The proposed roles of CL in these membranes include mainly two aspects: the effects on the structure and dynamics of the membranes' lipid component and the interplay with membrane-associated proteins.
Pöyry, Sanja   +7 more
openaire   +1 more source

Structural insights into cardiolipin replacement by phosphatidylglycerol in a cardiolipin-lacking yeast respiratory supercomplex

open access: yesNature Communications, 2023
Cardiolipin is a hallmark phospholipid of mitochondrial membranes. Despite established significance of cardiolipin in supporting respiratory supercomplex organization, a mechanistic understanding of this lipid-protein interaction is still lacking.
Corey F. Hryc   +9 more
doaj   +1 more source

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