Results 11 to 20 of about 66,906 (291)
Caspase-8 binding to cardiolipin in giant unilamellar vesicles provides a functional docking platform for bid. [PDF]
PLoS ONE, 2013 Caspase-8 is involved in death receptor-mediated apoptosis in type II cells, the proapoptotic programme of which is triggered by truncated Bid. Indeed, caspase-8 and Bid are the known intermediates of this signalling pathway.
Olivier Jalmar +10 more
doaj +13 more sources
Cardiolipin exposure on the outer mitochondrial membrane modulates α-synuclein
Nature Communications, 2018 Cardiolipin is a phospholipid component of the inner mitochondrial membrane. Here the authors demonstrate that cardiolipin interacts with mutant α-synuclein, and that impaired cardiolipin function can lead to spread of α-synuclein between neurons.
Tammy Ryan +10 more
doaj +2 more sources
Cells, 2021 The present review is an attempt to conceptualize a contemporary understanding about the roles that cardiolipin, a mitochondrial specific conical phospholipid, and non-bilayer structures, predominantly found in the inner mitochondrial membrane (IMM ...
Edward S. Gasanoff +2 more
doaj +2 more sources
Cell Communication and SignalingBackground Cardiolipin (CL) plays a critical role in maintaining mitochondrial membrane integrity and overall mitochondrial homeostasis. Recent studies have suggested that mitochondrial damage resulting from abnormal cardiolipin remodelling is associated
Yiqun Hao +8 more
doaj +2 more sources
Selective remodeling of cardiolipin fatty acids in the aged rat heart [PDF]
Lipids in Health and Disease, 2006 Background The heart is rich in cardiolipin, a phospholipid acylated in four sites, predominately with linoleic acid. Whether or not aging alters the composition of cardiolipin acyl chains is controversial.
Rapoport Stanley I +3 more
doaj +3 more sources
mBio, 2020 The Salmonella enterica subsp. enterica serovar Typhimurium PhoPQ two-component system is activated within the intracellular phagosome environment, where it promotes remodeling of the outer membrane and resistance to innate immune antimicrobial peptides.
Junping Fan +4 more
doaj +2 more sources
Cardiolipin, Mitochondria, and Neurological Disease
Trends in endocrinology and metabolism, 2021 Over the past decade, it has become clear that lipid homeostasis is central to cellular metabolism. Lipids are particularly abundant in the central nervous system (CNS) where they modulate membrane fluidity, electric signal transduction, and synaptic ...
Micol Falabella +4 more
semanticscholar +1 more source
Cell Death and Disease, 2023 Mesenchymal stem cell (MSC) transplantation alleviates metabolic defects in diseased recipient cells by intercellular mitochondrial transport (IMT). However, the effect of host metabolic conditions on IMT and thereby on the therapeutic efficacy of MSCs ...
Shakti Sagar +13 more
semanticscholar +1 more source
Science Advances, 2023 Macrophage metabolic plasticity enables repurposing of electron transport from energy generation to inflammation and host defense. Altered respiratory complex II function has been implicated in cancer, diabetes, and inflammation, but regulatory ...
Mack B. Reynolds +8 more
semanticscholar +1 more source
Identification and assessment of cardiolipin interactions with E. coli inner membrane proteins
Science Advances, 2021 This study uses MD simulations to identify and analyze >700 binding sites for cardiolipin to a set of bacterial membrane proteins. Integral membrane proteins are localized and/or regulated by lipids present in the surrounding bilayer. While bacteria have
R. Corey +5 more
semanticscholar +1 more source