Results 41 to 50 of about 5,312 (162)

Aptamer‐mediated outer membrane destabilization overcomes low permeability resistance in Pseudomonas aeruginosa

open access: yesThe FEBS Journal, EarlyView.
DNA aptamers, Apt 60 and Apt 173, target the BamA protein to compromise outer membrane integrity in Pseudomonas aeruginosa, making it susceptible to Azithromycin, an antibiotic that is otherwise poorly effective due to the low‐permeability membrane.
Rupany Selvam   +4 more
wiley   +1 more source

Phase Behavior Of Cardiolipin [PDF]

open access: yes, 2012
Cardiolipin is a phospholipid with negatively charged headgroups. This lipid is structurally unique in its quadruple-chained configuration and functionally unique in its nearly exclusive involvement in the cellular energy production processes.
Chen, Yi-fan
core  

Assessing phospholipase A2 activity toward cardiolipin by mass spectrometry. [PDF]

open access: yes, 2013
Cardiolipin, a major component of mitochondria, is critical for mitochondrial functioning including the regulation of cytochrome c release during apoptosis and proper electron transport.
Jian Cao   +9 more
core   +1 more source

Toward understanding the catalytic mechanism for two classes of bacterial phospholipid N‐methyltransferases

open access: yesThe FEBS Journal, EarlyView.
Phospholipid N‐methyltransferases (Pmts) synthesize phosphatidylcholine in many bacteria. In this study, we compared the catalytic mechanisms of two bacterial Pmt classes: the Rhodobacter (R‐) and the Sinorhizobium (S‐) type. Representative enzymes for each class were derived from Rubellimicrobium thermophilum and Agrobacterium tumefaciens ...
Irina Shevyreva   +5 more
wiley   +1 more source

Untersuchung der immunstimulatorischen Eigenschaften des Phospholipids Cardiolipin

open access: yes, 2017
Die Zielsetzung dieser Arbeit war die Untersuchung der immunstimulatorischen Fähigkeiten des Phospholipids Cardiolipin. Cardiolipin erfüllt die Kriterien eines Pathogen-assoziierten-molekularen-Musters (pathogen-associated molecular pattern; PAMP). Zudem
Bauer, Stefan (Prof. Dr.)   +1 more
core   +1 more source

Highly Canalized MinD Transfer and MinE Sequestration Explain the Origin of Robust MinCDE-Protein Dynamics [PDF]

open access: yes, 2012
Min-protein oscillations in Escherichia coli are characterized by the remarkable robustness with which spatial patterns dynamically adapt to variations of cell geometry.
Frey, Erwin   +3 more
core   +1 more source

Design and Implementation of an Automated Interpretation Algorithm for Lupus Anticoagulant Functional Testing

open access: yesInternational Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction Lupus anticoagulant (LA) testing is essential, albeit complex, in the laboratory diagnosis of antiphospholipid syndrome (APS). Given the multi‐step workflow and the variability introduced by anticoagulant therapy, reagent differences, and interpretive approaches, result interpretation requires expert evaluation.
Chiara Novelli   +4 more
wiley   +1 more source

Antigenicity of bacterial membrane-cardiolipin and reactivity of anti-cardiolipin antibody with bacteria and DNA [PDF]

open access: yes, 1988
I investigated the possibility of production of antibody to bacterial membrane-cardiolipin using cardiolipin micelles, Staphylococcus aureus (S.aureus) and L-form of S. aureus. I also investigated and the reactivity of anti-cardiolipin (CL) antibody with
Nakamura, Tomoaki, Tomoaki NAKAMURA
core   +1 more source

Australian clinical practice guideline: diagnosis and treatment of idiopathic multicentric Castleman disease

open access: yesInternal Medicine Journal, EarlyView.
Abstract Idiopathic multicentric Castleman disease (iMCD) is a rare condition. The pathogenesis is incompletely understood; however, interleukin‐6 (IL‐6) is a major mediator. The clinical presentation is heterogeneous, from mild constitutional symptoms to severe multi‐organ failure.
Dipti Talaulikar   +16 more
wiley   +1 more source

Activity modulation of the Escherichia coli F1FO ATP synthase by a designed antimicrobial peptide via cardiolipin sequestering

open access: yes, 2023
Most antimicrobial peptides (AMPs) exert their microbicidal activity through membrane permeabilization. The designed AMP EcDBS1R4 has a cryptic mechanism of action involving the membrane hyperpolarization of Escherichia coli, suggesting that EcDBS1R4 may
López Montero, Iván   +6 more
core  

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