Results 51 to 60 of about 66,906 (291)

Role of Cardiolipin in Mitochondrial Signaling Pathways

Front. Cell Dev. Biol., 2017
The phospholipid cardiolipin (CL) is an essential constituent of mitochondrial membranes and plays a role in many mitochondrial processes, including respiration and energy conversion.
Jan Dudek
semanticscholar   +1 more source

The (non‐)sense of detecting anti‐cardiolipin and anti‐β2glycoprotein I IgM antibodies in the antiphospholipid syndrome

Journal of Thrombosis and Haemostasis, 2020
The antiphospholipid syndrome (APS) is characterized by thrombosis and/or pregnancy morbidity with the persistent presence of lupus anticoagulant (LAC), anti‐cardiolipin (aCL) and/or anti‐β2glycoprotein I (aβ2GPI) antibodies of the immunoglobulin G ...
W. Chayoua, H. Kelchtermans, J. Gris, G. Moore, J. Musial, D. Wahl, P. D. de Groot, B. Laat, K. Devreese   +8 more
semanticscholar   +1 more source

Immunological study on cardiolipin from Escherichia coli [PDF]

, 1968
For the first time we found that cardiolipin was contained abundantly in Eschrichia coli, and we succeeded in isolating and purifying it as reported previously. With this E.
Kanemasa, Yasuhiro
core   +1 more source

Cardiolipin’s Remodeling Rules Revealed: The Role of the Cellular Lipidome

Cell Reports, 2020
In this issue of Cell Reports, Oemer et al. (2020) define the acyl chain composition of cardiolipin and other lipid classes in murine tissues. They then employ artificial neural networks to predict mechanisms that govern cardiolipin tissue specificity ...
Olivia L. Sniezek, Arianna F. Anzmann, Steven M. Claypool, Hilary J. Vernon   +3 more
doaj   +1 more source

Structural insights into cardiolipin replacement by phosphatidylglycerol in a cardiolipin-lacking yeast respiratory supercomplex

Nature Communications, 2023
Cardiolipin is a hallmark phospholipid of mitochondrial membranes. Despite established significance of cardiolipin in supporting respiratory supercomplex organization, a mechanistic understanding of this lipid-protein interaction is still lacking.
Corey F. Hryc, Venkata K. P. S. Mallampalli, Evgeniy I. Bovshik, Stavros Azinas, Guizhen Fan, Irina I. Serysheva, Genevieve C. Sparagna, Matthew L. Baker, Eugenia Mileykovskaya, William Dowhan   +9 more
doaj   +1 more source

Cardiolipin oxidized by ROS from complex II acts as a target of gasdermin D to drive mitochondrial pore and heart dysfunction in endotoxemia.

Cell Reports
Cardiac dysfunction, an early complication of endotoxemia, is the major cause of death in intensive care units. No specific therapy is available at present for this cardiac dysfunction.
Yan Tang, Junru Wu, Xu Sun, Shasha Tan, Wenbo Li, Siyu Yin, Lun Liu, Yuanyuan Chen, Yuanyuan Liu, Qian Tan, You-Jing Jiang, Wenjing Yang, Wei Huang, Chunyan Weng, Qing Wu, Yao Lu, Hong Yuan, Qingzhong Xiao, Alex F. Chen, Qin Xu, T. Billiar, Jingjing Cai   +21 more
semanticscholar   +1 more source

Cardiolipin Synthesis and Outer Membrane Localization Are Required for Shigella flexneri Virulence

mBio, 2017
Cardiolipin, an anionic phospholipid that resides at the poles of the inner and outer membranes, is synthesized primarily by the putative cardiolipin synthase ClsA in Shigella flexneri. An S.
Rachael M. Rossi, Lauren Yum, Hervé Agaisse, Shelley M. Payne   +3 more
doaj   +1 more source

Functional diversity among cardiolipin binding sites on the mitochondrial ADP/ATP carrier

EMBO Journal
Lipid-protein interactions play a multitude of essential roles in membrane homeostasis. Mitochondrial membranes have a unique lipid-protein environment that ensures bioenergetic efficiency.
Nanami Senoo, Dinesh K. Chinthapalli, Matthew G. Baile, V. Golla, Bodhisattwa Saha, A. Oluwole, O. Ogunbona, James A. Saba, Teona Munteanu, Yllka Valdez, Kevin Whited, Macie S. Sheridan, Dror S. Chorev, Nathan N. Alder, Eric R May, Carol V Robinson, S. Claypool   +16 more
semanticscholar   +1 more source

Analysis of neuronal cardiolipin and monolysocardiolipin from biological samples with cyclic ion mobility mass spectrometry

Frontiers in Physiology
The mitochondrial phospholipid cardiolipin (CL) is essential for proper mitochondrial function and energy production. Cardiolipin has four distinct fatty acid tails with varying expression compositions, resulting in a highly variable tissue-specific ...
Katlynn J. Emaus, Katlynn J. Emaus, Carmen A. Dunbar, Carmen A. Dunbar, Joseph Caruso, Brandon T. Ruotolo, Joseph M. Wider, Joseph M. Wider, Joseph M. Wider, Thomas H. Sanderson, Thomas H. Sanderson, Thomas H. Sanderson, Thomas H. Sanderson   +12 more
doaj   +1 more source

Microanalysis of cardiolipin in small biopsies including skeletal muscle from patients with mitochondrial disease

Journal of Lipid Research, 1999
Cardiolipin is a specific mitochondrial phospholipid that is present in mammalian tissues in low concentration. To measure cardiolipin in small biopsies from patients with mitochondrial disease, we developed a new technique that can detect subnanomolar ...
Michael Schlame, Sara Shanske, Steven Doty, Thomas König, Thomas Sculco, Salvatore DiMauro, Thomas J.J. Blanck   +6 more
doaj   +1 more source