Results 71 to 80 of about 66,906 (291)

Cross-species complementation of bacterial- and eukaryotic-type cardiolipin synthases

Microbial Cell, 2017
The glycerophospholipid cardiolipin is a unique constituent of bacterial and mitochondrial membranes. It is involved in forming and stabilizing high molecular mass membrane protein complexes and in maintaining membrane architecture.
Petra Gottier, Mauro Serricchio, Rita Vitale, Angela Corcelli, Peter Bütikofer   +4 more
doaj   +1 more source

A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity

Advanced Science, EarlyView.
This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu, Xinyu Sun, Wanxia Ma, Jianming Yang, Xuan Sun, Lisong Zhang, Yumeng Liu, Tianshu Ren, Qi Wang, Jingyu Wang, Xiao Li, Xianping Peng, Liu Yang, Junqiang Lv, Zhi Yao, Zhi‐Song Zhang, Quan Wang   +16 more
wiley   +1 more source

Impaired cardiac and skeletal muscle bioenergetics in children, adolescents, and young adults with Barth syndrome [PDF]

, 2017
Barth syndrome (BTHS) is an X‐linked condition characterized by altered cardiolipin metabolism and cardioskeletal myopathy. We sought to compare cardiac and skeletal muscle bioenergetics in children, adolescents, and young adults with BTHS and unaffected
Altschuld, American College of Sports Medicine, Bahi, Barth, Bashir, Bione, Bissler, Cade, Cade, Chance, Chance, Conway, Edwards, El-Sharkawy, Gomez, Gonzalvez, Hiona, Hom, Hudsmith, Ingwall, Kemp, Kemp, Kemp, Kemp, Kushmerick, Lang, Lanza, Lanza, Larson-Meyer, Layec, Liu, Matthews, Meyer, Meyer, Minotti, Naressi, Nascimben, Neubauer, Powers, Ratel, Roussel, Sapega, Schlame, Sgobbo, Smith, Spencer, Spencer, Spoladore, Takahashi, Taylor, Taylor, Thaveau, Thompson, Tonson, Vanhamme, Wang, Wasserman, Waters, Xu, Yao, Zhang, Zoll   +61 more
core   +2 more sources

Relative Exchangeable Copper Confirms Wilson Disease and Supports Reclassification of the ATP7B p.Met665Ile Variant With Conflicting Pathogenicity Evidence

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Wilson disease (WD) is an autosomal recessive disorder of copper metabolism caused by ATP7B mutations. Diagnosis is usually straightforward in symptomatic patients, but can be challenging in children and adolescents with mild liver disease, borderline urinary copper excretion, or inconclusive genetic findings.
Emanuele Nicastro, Caterina Zuccoli, Roberto Marozzi, Antonino Barletta, Lisa Licini, Paola Tebaldi, Valeria Casotti, Mariangela Stinco, Lidia Pezzani, Maria Iascone, Lorenzo D'Antiga   +10 more
wiley   +1 more source

Cardiolipin dynamics promote membrane remodeling by mitochondrial OPA1

Nature Communications
Cardiolipin is a mitochondria-specific phospholipid that forms heterotypic interactions with membrane-shaping proteins and regulates the dynamic remodeling and function of mitochondria. However, the precise mechanisms through which cardiolipin influences
Sirikrishna Thatavarthy, Luciano A. Abriata, Fernando Teixeira Pinto Meireles, Kelly E. Zuccaro, Akhil Gargey Iragavarapu, Gabriela May Sullivan, Frank R. Moss, Adam Frost, Matteo Dal Peraro, Halil Aydin   +9 more
doaj   +1 more source

PON2 Deficiency Leads to Increased Susceptibility to Diet-Induced Obesity. [PDF]

, 2019
(1) Background: Paraoxonase 2 (PON2) is a ubiquitously expressed protein localized to endoplasmic reticulum and mitochondria. Previous studies have shown that PON2 exhibits anti-oxidant and anti-inflammatory functions, and PON2-deficient (PON2-def) mice ...
Fogelman, Alan M, Lusis, Aldons J, Meng, Yonghong, Reddy, Srinivasa T, Reue, Karen, Sallam, Tamer, Shih, Diana M, Shu, Michelle L, Tontonoz, Peter, Vergnes, Laurent   +9 more
core   +1 more source

Cardiolipin-Dependent Mitophagy Guides Outcome after Traumatic Brain Injury

Journal of Neuroscience, 2019
Mitochondrial energy production is essential for normal brain function. Traumatic brain injury (TBI) increases brain energy demands, results in the activation of mitochondrial respiration, associated with enhanced generation of reactive oxygen species ...
Honglu Chao, Chao Lin, Q. Zuo, Yinlong Liu, Mengqing Xiao, Xiupeng Xu, Zheng Li, Zhongyuan Bao, Huimei Chen, Y. You, P. Kochanek, H. Yin, Ning Liu, V. Kagan, H. Bayır, Jing Ji   +15 more
semanticscholar   +1 more source

Cardiolipin Stabilizes Respiratory Chain Supercomplexes [PDF]

Journal of Biological Chemistry, 2003
Cardiolipin stabilized supercomplexes of Saccharomyces cerevisiae respiratory chain complexes III and IV (ubiquinol:cytochrome c oxidoreductase and cytochrome c oxidase, respectively), but was not essential for their formation in the inner mitochondrial membrane because they were found also in a cardiolipin-deficient strain.
Pfeiffer, Kathy, Gohil, Vishal, Stuart, Rosemary A., Hunte, Carola, Brandt, Ulrich, Greenberg, Miriam L., Schägger, Hermann   +6 more
openaire   +4 more sources

MIC26 and MIC27 cooperate to regulate cardiolipin levels and the landscape of OXPHOS complexes

Life Science Alliance, 2020
Apolipoproteins of MICOS, MIC26 and MIC27, cooperatively manage cristae structure, cardiolipin levels, and the global stability and integrity of respiratory chain supercomplexes and F1Fo–ATP synthase.
Ruchika Anand, Arun Kumar Kondadi, Jana Meisterknecht, Mathias Golombek, O. Nortmann, J. Riedel, Leon Peifer-Weiß, Nahal Brocke-Ahmadinejad, David Schlütermann, B. Stork, Thomas O. Eichmann, I. Wittig, A. Reichert   +12 more
semanticscholar   +1 more source

Autoantibodies to Joint‐Related Peptides Are Associated with Onset of Rheumatoid Arthritis in Presymptomatic Seronegative Individuals

Arthritis &Rheumatology, Accepted Article.
Objective To identify autoantibodies in presymptomatic individuals that associate with the onset of rheumatoid arthritis (RA), and to distinguish early RA from osteoarthritis (OA), particularly in individuals lacking classic RA serological markers. Methods We analyzed serum and plasma from three cohorts: pre‐symptomatic individuals who later developed ...
Outi Sareila, Linda Johansson, Anders Lundquist, Monica Leu Agelii, Lei Cheng, Yibo He, Erik Lönnblom, Maria Andersson, Jan Kihlberg, Anders Esberg, Inger Gjertsson, Rikard Holmdahl, Solbritt Rantapää‐Dahlqvist   +12 more
wiley   +1 more source