The F1Fo-ATP synthase α subunit of Candida albicans induces inflammatory responses by controlling amino acid catabolism [PDF]
Virulence, 2023 Sepsis is a leading cause of fatality in invasive candidiasis. The magnitude of the inflammatory response is a determinant of sepsis outcomes, and inflammatory cytokine imbalances are central to the pathophysiological processes.
Shuixiu Li +9 more
doaj +4 more sources
ATP binding by an F1Fo ATP synthase ε subunit is pH dependent, suggesting a diversity of ε subunit functional regulation in bacteria [PDF]
Frontiers in Molecular Biosciences, 2023 It is a conjecture that the ε subunit regulates ATP hydrolytic function of the F1Fo ATP synthase in bacteria. This has been proposed by the ε subunit taking an extended conformation, with a terminal helix probing into the central architecture of the ...
Alexander Krah +8 more
doaj +4 more sources
F1FO ATP synthase molecular motor mechanisms [PDF]
Frontiers in Microbiology, 2022 The F-ATP synthase, consisting of F1 and FO motors connected by a central rotor and the stators, is the enzyme responsible for synthesizing the majority of ATP in all organisms. The F1 (αβ)3 ring stator contains three catalytic sites.
Wayne D. Frasch +2 more
doaj +4 more sources
Cyclophilin D deficiency attenuates mitochondrial F1Fo ATP synthase dysfunction via OSCP in Alzheimer's disease [PDF]
Neurobiology of Disease, 2019 Mitochondrial dysfunction is pivotal in inducing synaptic injury and neuronal stress in Alzheimer's disease (AD). Mitochondrial F1Fo ATP synthase deregulation is a hallmark mitochondrial defect leading to oxidative phosphorylation (OXPHOS) failure in ...
Esha Gauba, Hao Chen, Lan Guo, Heng Du
doaj +4 more sources
Deregulation of mitochondrial F1FO-ATP synthase via OSCP in Alzheimer’s disease [PDF]
Nature Communications, 2016 F1FO ATP synthase is a critical enzyme for the maintenance of mitochondrial function. Here the authors demonstrate that loss of the F1FO-ATP synthase subunit OSCP and the interaction of OSCP with Aβ peptide in Alzheimer’s disease patients and mouse ...
Simon J. Beck +10 more
doaj +3 more sources
pH-dependent 11° F1FO ATP synthase sub-steps reveal insight into the FO torque generating mechanism [PDF]
eLife, 2021 Most cellular ATP is made by rotary F1FO ATP synthases using proton translocation-generated clockwise torque on the FO c-ring rotor, while F1-ATP hydrolysis can force counterclockwise rotation and proton pumping.
Seiga Yanagisawa, Wayne D Frasch
doaj +2 more sources
Activity modulation of the Escherichia coli F1FO ATP synthase by a designed antimicrobial peptide via cardiolipin sequestering [PDF]
iScience, 2023 Summary: Most antimicrobial peptides (AMPs) exert their microbicidal activity through membrane permeabilization. The designed AMP EcDBS1R4 has a cryptic mechanism of action involving the membrane hyperpolarization of Escherichia coli, suggesting that ...
Marcin Makowski +6 more
doaj +2 more sources
The δ subunit of F1Fo-ATP synthase is required for pathogenicity of Candida albicans [PDF]
Nature Communications, 2021 F1Fo-ATP synthase is a key enzyme for energy production in fungi. Here, the authors show that the δ subunit of the enzyme is required for Candida albicans lethal infection and represents a potential therapeutic target.
Shuixiu Li +9 more
doaj +2 more sources
Changes within the central stalk of E. coli F1Fo ATP synthase observed after addition of ATP [PDF]
Communications Biology, 2023 Cryo-EM structures of E. coli F1Fo ATP synthase highlight the role of the inhibitory ε subunit in regulating the torsional movement of the central stalk within the Fo motor and central stalk flexibility in coupling the F1 and Fo motors.
Meghna Sobti +5 more
doaj +2 more sources
The mitochondrial Hsp70 controls the assembly of the F1FO-ATP synthase [PDF]
Nature Communications, 2023 The mitochondrial ATP synthase produces the bulk of cellular ATP. Here, the authors report a function of the mitochondrial Hsp70 in the formation of the catalytical head and in its assembly with the peripheral stalk to form the mature ATP synthase.
Jiyao Song +7 more
doaj +2 more sources