Impact of F1Fo-ATP-synthase dimer assembly factors on mitochondrial function and organismic aging [PDF]
Microbial Cell, 2018 In aerobic organisms, mitochondrial F1Fo-ATP-synthase is the major site of ATP production. Beside this fundamental role, the protein complex is involved in shaping and maintenance of cristae.
Nadia G Rampello +3 more
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A mitochondrial megachannel resides in monomeric F1FO ATP synthase [PDF]
Nature Communications, 2019 The ATP synthase has been suggested to contain the mitochondrial permeability transition pore (mPTP), which has a crucial role in cell death. Here the authors show that reconstituted ATP synthase monomers form voltage-gated and Ca2+ -activated channels ...
Nelli Mnatsakanyan +6 more
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Bovine F1Fo ATP synthase monomers bend the lipid bilayer in 2D membrane crystals [PDF]
eLife, 2015 We have used a combination of electron cryo-tomography, subtomogram averaging, and electron crystallographic image processing to analyse the structure of intact bovine F1Fo ATP synthase in 2D membrane crystals.
Chimari Jiko +9 more
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A Bacterial Virulence Protein Promotes Pathogenicity by Inhibiting the Bacterium’s Own F1Fo ATP Synthase [PDF]
Cell, 2013 Several intracellular pathogens, including Salmonella enterica and Mycobacterium tuberculosis, require the virulence protein MgtC to survive within macrophages and to cause a lethal infection in mice. We now report that, unlike secreted virulence factors that target the host vacuolar ATPase to withstand phagosomal acidity, the MgtC protein acts on ...
Eun-Jin Lee +2 more
exaly +5 more sources
Cryo-EM structures provide insight into how E. coli F1Fo ATP synthase accommodates symmetry mismatch [PDF]
Nature Communications, 2020 F1Fo ATP synthase consists of two coupled rotary molecular motors: the soluble ATPase F1 and the transmembrane Fo. Here, the authors present cryo-EM structures of E.
Meghna Sobti +7 more
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Frontiers in Microbiology, 2018 Previous work has explored link between mitochondrial biology and fungal pathogenicity in F1Fo-ATP synthase in Candida albicans. In this work we have detailed the more specific roles of the F1Fo-ATP synthase β subunit, a key protein subunit of F1Fo-ATP ...
Shui-Xiu Li +15 more
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MICOS and MIMAS, multifunctional assemblies linking mitochondrial biogenesis, architecture, and function. [PDF]
Protein SciAbstract Mitochondrial cristae architecture is central for optimal oxidative phosphorylation and a healthy mitochondrial physiology. The intricate architecture of the inner mitochondrial membrane relies on protein complexes that compartmentalize the membrane by imposing membrane curvature, forming membrane contact sites or membrane subdomains ...
Horten P, Song K, Pfanner N, Rampelt H.
europepmc +2 more sources
Distinct structural features of Pseudomonas aeruginosa ATP synthase revealed by cryo-electron microscopy [PDF]
Nature CommunicationsF1Fo ATP synthase is the ubiquitous enzyme that synthesizes cellular ATP by coupling proton-motive force with rotational catalysis. Structural differences between prokaryotic and eukaryotic ATP synthases offer potential targets for antimicrobial ...
Meghna Sobti +8 more
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Natural products and other inhibitors of F1FO ATP synthase. [PDF]
Eur J Med Chem, 2020 F1FO ATP synthase is responsible for the production of >95% of all ATP synthesis within the cell. Dysregulation of its expression, activity or localization is linked to various human diseases including cancer, diabetes, and Alzheimer's and Parkinson's disease.
Patel BA, D'Amico TL, Blagg BSJ.
europepmc +4 more sources
Genetic origins and proteomic consequences of kinetoplast loss in trypanosomes. [PDF]
PLoS PathogensThe kinetoplast incorporates the large mitochondrial genome present in the eponymous Kinetoplastida. Trypanosoma brucei is an African trypanosome that can lose kinetoplast DNA (kDNA), however, when the nuclear-encoded gamma subunit of the mitochondrial ...
Melanie Ridgway +6 more
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