Results 31 to 40 of about 1,898 (145)

Dual role of Mic10 in mitochondrial cristae organization and ATP synthase-linked metabolic adaptation and respiratory growth

Cell Reports, 2022
Summary: Invaginations of the mitochondrial inner membrane, termed cristae, are hubs for oxidative phosphorylation. The mitochondrial contact site and cristae organizing system (MICOS) and the dimeric F1Fo-ATP synthase play important roles in controlling
Heike Rampelt, Florian Wollweber, Mariya Licheva, Rinse de Boer, Inge Perschil, Liesa Steidle, Thomas Becker, Maria Bohnert, Ida van der Klei, Claudine Kraft, Martin van der Laan, Nikolaus Pfanner   +11 more
doaj   +1 more source

Binding properties of the anti-TB drugs bedaquiline and TBAJ-876 to a mycobacterial F-ATP synthase

Current Research in Structural Biology, 2022
Tuberculosis (TB), the deadly disease caused by Mycobacterium tuberculosis (Mtb), kills more people worldwide than any other bacterial infectious disease. There has been a recent resurgence of TB drug discovery activities, resulting in the identification
Alexander Krah, Gerhard Grüber, Peter J. Bond   +2 more
doaj   +1 more source

Su e of the Yeast F1Fo-ATP Synthase Forms Homodimers [PDF]

Journal of Biological Chemistry, 2002
The yeast F(1)F(o)-ATP synthase forms a dimeric complex in the mitochondrial inner membrane. Dimerization of two F(1)F(o) monomeric complexes involves the physical association of two membrane-embedded F(o) sectors and in a manner, which is dependent on the F(o) subunit, Su e.
Susanne, Brunner, Valerie, Everard-Gigot, Rosemary A, Stuart   +2 more
openaire   +2 more sources

The INA complex facilitates assembly of the peripheral stalk of the mitochondrial F1Fo-ATP synthase. [PDF]

EMBO J, 2014
Mitochondrial F1Fo-ATP synthase generates the bulk of cellular ATP. This molecular machine assembles from nuclear- and mitochondria-encoded subunits. Whereas chaperones for formation of the matrix-exposed hexameric F1-ATPase core domain have been identified, insight into how the nuclear-encoded F1-domain assembles with the membrane-embedded Fo-region ...
Lytovchenko O, Naumenko N, Oeljeklaus S, Schmidt B, von der Malsburg K, Deckers M, Warscheid B, van der Laan M, Rehling P.   +8 more
europepmc   +7 more sources

Cristae architecture is determined by an interplay of the MICOS complex and the F1FO ATP synthase via Mic27 and Mic10

Microbial Cell, 2017
The inner boundary and the cristae membrane are connected by pore-like structures termed crista junctions (CJs). The MICOS complex is required for CJ formation and enriched at CJs. Here, we address the roles of the MICOS subunits Mic27 and Mic10.
Katharina Eydt, Karen M. Davies, Christina Behrendt, Ilka Wittig, Andreas S. Reichert   +4 more
doaj   +1 more source

The six steps of the complete F1-ATPase rotary catalytic cycle

Nature Communications, 2021
F1Fo ATP synthase works using a rotary catalysis mechanism. Here, the authors report cryo-EM structures of Bacillus PS3 F1-ATPase encompassing the complete set of six states taken up during the catalytic cycle, including the binding- and catalytic-dwell ...
Meghna Sobti, Hiroshi Ueno, Hiroyuki Noji, Alastair G. Stewart   +3 more
doaj   +1 more source

Alteration of the F1Fo ATP Synthase Causes Metabolic Remodeling in Breast Cancer Cells [PDF]

Curr Dev Nutr, 2021
Objectives The F1Fo ATP synthase is a multienzyme complex that produces mitochondrial ATP. Aberrant expression or assembly of F1Fo ATP synthase subunits leads to alterations in energy metabolism. We recently found that breast cancer cells exposed to fluid shear stress (FSS) have significantly enhanced metastatic behavior including chemoresistance and ...
Tracie Dunn, Neli Mnatsakanyan, Spenser Brown, Joseph Jansen, Mary Margaret Hayden, Elizabeth Jonas, Yonghyun Kim, Han-A Park   +7 more
europepmc   +3 more sources

Oxidative Phosphorylation Is Required for Powering Motility and Development of the Sleeping Sickness Parasite Trypanosoma brucei in the Tsetse Fly Vector

mBio, 2022
The single-celled parasite Trypanosoma brucei is transmitted by hematophagous tsetse flies. Life cycle progression from mammalian bloodstream form to tsetse midgut form and, subsequently, infective salivary gland form depends on complex developmental ...
Caroline E. Dewar, Aitor Casas-Sanchez, Constentin Dieme, Aline Crouzols, Lee R. Haines, Álvaro Acosta-Serrano, Brice Rotureau, Achim Schnaufer   +7 more
doaj   +1 more source

The aerobic mitochondrial ATP synthesis from a comprehensive point of view [PDF]

Open Biology, 2020
Most of the ATP to satisfy the energetic demands of the cell is produced by the F1Fo-ATP synthase (ATP synthase) which can also function outside the mitochondria.
Alessandro Maria Morelli, Silvia Ravera, Isabella Panfoli   +2 more
doaj   +1 more source

Cyclophilin D Promotes Brain Mitochondrial F1FO ATP Synthase Dysfunction in Aging Mice. [PDF]

J Alzheimers Dis, 2017
Brain aging is the known strongest risk factor for Alzheimer’s disease (AD). In recent years, mitochondrial deficits have been proposed to be a common mechanism linking brain aging to AD. Therefore, to elucidate the causative mechanisms of mitochondrial dysfunction in aging brains is of paramount importance for our understanding of the pathogenesis of ...
Gauba E, Guo L, Du H.
europepmc   +4 more sources