Mitochondrial permeability transition pore desensitization by a novel dispiranic derivative prevents cardiac reperfusion injury [PDF]
Redox BiologyMitochondrial permeability transition pore (PTP) opening is a major determinant of cardiac ischemia/reperfusion (I/R) injury, contributing to cardiomyocyte death and impaired cardiac function following revascularization.
Giampaolo Morciano +18 more
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Rethinking Mitchell's Chemiosmotic Theory: Potassium Dominates Over Proton Flux to Drive Mitochondrial F1Fo-ATP Synthase [PDF]
Function, 2022 Edoardo Bertero, Christoph Maack
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Caspase inhibition rescues F1Fo ATP synthase dysfunction-mediated dendritic spine elimination. [PDF]
Sci Rep, 2020 AbstractDendritic spine injury underlies synaptic failure in many neurological disorders. Mounting evidence suggests a mitochondrial pathway of local nonapoptotic caspase signaling in mediating spine pruning. However, it remains unclear whether this caspase signaling plays a key role in spine loss when severe mitochondrial functional defects are ...
Chen H, Tian J, Guo L, Du H.
europepmc +4 more sources
Mitochondrial cristae remodeling: Mechanisms, functions, and pathology [PDF]
Cell InsightMitochondrial cristae are the principal sites of oxidative phosphorylation and are central to mitochondria-dependent energy metabolism. Rather than static folds, cristae are dynamic bioenergetic compartments that remodel in response to physiological and ...
Jianglong Yu +7 more
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The GPCR NMUR-1 mediates neural regulation of energy homeostasis in response to pathogen infection [PDF]
Infection and ImmunityA key challenge in immunology is understanding how the innate immune system achieves specificity against diverse pathogens. Our previous work in Caenorhabditis elegans identified NMUR-1, a neuronal G protein-coupled receptor homologous to mammalian ...
Phillip Wibisono +4 more
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The new role of F1Fo ATP synthase in mitochondria-mediated neurodegeneration and neuroprotection. [PDF]
Exp Neurol, 2020 The mitochondrial F1Fo ATP synthase is one of the most abundant proteins of the mitochondrial inner membrane, which catalyzes the final step of oxidative phosphorylation to synthesize ATP from ADP and Pi. ATP synthase uses the electrochemical gradient of protons (ΔμH+) across the mitochondrial inner membrane to synthesize ATP.
Mnatsakanyan N, Jonas EA.
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Author Correction: Mitochondrial F1FO ATP synthase determines the local proton motive force at cristae rims [PDF]
EMBO ReportsBettina Rieger +4 more
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Function, 2022 ATP synthase (F1Fo) synthesizes daily our body's weight in ATP, whose production-rate can be transiently increased several-fold to meet changes in energy utilization.
Magdalena Juhaszova +11 more
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Thymoquinone Inhibits Escherichia coli ATP Synthase and Cell Growth. [PDF]
PLoS ONE, 2015 We examined the thymoquinone induced inhibition of purified F1 or membrane bound F1FO E. coli ATP synthase. Both purified F1 and membrane bound F1FO were completely inhibited by thymoquinone with no residual ATPase activity. The process of inhibition was
Zulfiqar Ahmad +2 more
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PLoS Pathogens, 2021 The mitochondrial electron transport chain (mETC) and F1Fo-ATP synthase are of central importance for energy and metabolism in eukaryotic cells. The Apicomplexa, important pathogens of humans causing diseases such as toxoplasmosis and malaria, depend on ...
Andrew E Maclean +6 more
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