Results 41 to 50 of about 1,898 (145)
Microbiology Spectrum, 2023 The Mycobacterium tuberculosis (Mtb) F-ATP synthase generates most of the biological energy currency ATP. Previously, we identified the mycobacterium-specific loop of the F-ATP synthase subunit γ as a new anti-tuberculosis target and discovered the novel
Priya Ragunathan +15 more
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Novel Drugs Targeting the c-Ring of the F1FO-ATP Synthase.
Mini reviews in medicinal chemistry, 2016 Increasing evidence highlights the role of the ATP synthase/hydrolase, also known as F1FO-complex, as key molecular and enzymatic switch between cell life and death, thus increasing the enzyme attractiveness as drug target in pharmacology. Being inhibition of ATP production usually linked to antiproliferative properties, drugs targeting the enzyme ...
PAGLIARANI, ALESSANDRA +2 more
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Oxidative stress battles neuronal Bcl-xL in a fight to the death
Neural Regeneration Research, 2021 Bcl-xL is a pro-survival protein of the Bcl2 family found in the mitochondrial membrane. Bcl-xL supports growth, development, and maturation of neurons, and it also prevents neuronal death during neurotoxic stimulation.
Han-A Park +2 more
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Obstruction of transmembrane helical movements in subunit a blocks proton pumping by F1Fo ATP synthase. [PDF]
J Biol Chem, 2013 Subunit a plays a key role in promoting H(+) transport-coupled rotary motion of the subunit c ring in F1Fo ATP synthase. H(+) binding and release occur at Asp-61 in the middle of the second transmembrane helix (TMH) of Fo subunit c. H(+) are thought to reach cAsp61 via aqueous half-channels formed by TMHs 2-5 of subunit a.
Moore KJ, Fillingame RH.
europepmc +4 more sources
Mitochondrial DNA is critical for longevity and metabolism of transmission stage Trypanosoma brucei.
PLoS Pathogens, 2018 The sleeping sickness parasite Trypanosoma brucei has a complex life cycle, alternating between a mammalian host and the tsetse fly vector. A tightly controlled developmental programme ensures parasite transmission between hosts as well as survival ...
Caroline E Dewar +6 more
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Frontiers in Molecular Biosciences, 2023 Introduction: The ζ subunit is a potent inhibitor of the F1FO-ATPase of Paracoccus denitrificans (PdF1FO-ATPase) and related α-proteobacteria different from the other two canonical inhibitors of bacterial (ε) and mitochondrial (IF1) F1FO-ATPases.
Francisco Mendoza-Hoffmann +15 more
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Unusual features of the c-ring of F1FO ATP synthases [PDF]
Scientific Reports, 2019 AbstractMembrane integral ATP synthases produce adenosine triphosphate, the universal “energy currency” of most organisms. However, important details of proton driven energy conversion are still unknown. We present the first high-resolution structure (2.3 Å) of the in meso crystallized c-ring of 14 subunits from spinach chloroplasts.
A. V. Vlasov +15 more
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Cell Reports, 2018 The biological roles of the three natural F1FO-ATPase inhibitors, ε, ζ, and IF1, on cell physiology remain controversial. The ζ subunit is a useful model for deletion studies since it mimics mitochondrial IF1, but in the F1FO-ATPase of Paracoccus ...
Francisco Mendoza-Hoffmann +8 more
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Redox Biology, 2021 Reactive oxygen species (ROS) are a common product of active mitochondrial respiration carried in mitochondrial cristae, but whether cristae shape influences ROS levels is unclear.
Rubén Quintana-Cabrera +5 more
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The C Ring of the F1Fo ATP Synthase Forms the Mitochondrial Permeability Transition Pore: A Critical Appraisal. [PDF]
Front Oncol, 2014 The mitochondrial permeability transition pore (MPTP) is a non-specific pore in the inner mitochondrial membrane (IMM) whose opening is triggered by high matrix [Ca2+] to which it is sensitized by [Pi] and oxidative stress. MPTP opening plays a critical role in necrotic cell death such as in cardiac ischemia/reperfusion (I/R) injury and the action of ...
Halestrap AP.
europepmc +6 more sources