Results 41 to 50 of about 500,253 (300)

Membrane shape as a reporter for applied forces [PDF]

, 2008
Recent advances have enabled 3-dimensional reconstructions of biological structures in vivo, ranging in size and complexity from single proteins to multicellular structures. In particular, tomography and confocal microscopy have been exploited to capture
Antonny, Canham, Cheng, E. L. Peterson, Evans, Fertuck, Frey, Gerlich, H. J. Lee, Heinrich, Jenkins, Kusumi, Ledesma, Mills, Neuman, P. A. Wiggins, R. Phillips, Rawicz, Razani, Rodriguez-Boulan, Sheetz, Singer, Sougrat, Tian, Unwin, Upadhyaya, Vale, W. S. Klug, Waterman-Storer, Waugh, Waugh   +30 more
core   +2 more sources

Structural insights into membrane remodeling by SNX1 [PDF]

Proceedings of the National Academy of Sciences, 2021
Significance Coat proteins play a central role in the intracellular transport pathways by coupling two main functions: bending the membrane to generate transport carriers and binding to cargoes for their sorting into these carriers. Studies thus far have mostly solved the structure of coat proteins in solution, but their functional form ...
Yan Zhang, Xiaoyun Pang, Jian Li, Jiashu Xu, Victor W. Hsu, Fei Sun   +5 more
openaire   +2 more sources

Sbf/MTMR13 coordinates PI(3)P and Rab21 regulation in endocytic control of cellular remodeling. [PDF]

, 2012
Cells rely on the coordinated regulation of lipid phosphoinositides and Rab GTPases to define membrane compartment fates along distinct trafficking routes.
Cox, Sarah, Jean, Steve, Kiger, Amy, Robinson, Fred L, Schmidt, Eric J   +4 more
core   +1 more source

Genotype-Phenotype Correlations in Charcot-Marie-Tooth Disease Due to MTMR2 Mutations and Implications in Membrane Trafficking

Frontiers in Neuroscience, 2019
Charcot-Marie-Tooth type 4 (CMT4) is an autosomal recessive severe form of neuropathy with genetic heterogeneity. CMT4B1 is caused by mutations in the myotubularin-related 2 (MTMR2) gene and as a member of the myotubularin family, the MTMR2 protein is ...
Haicui Wang, Haicui Wang, Ayşe Kaçar Bayram, Rosanne Sprute, Rosanne Sprute, Ozkan Ozdemir, Ozkan Ozdemir, Emily Cooper, Matthias Pergande, Matthias Pergande, Stephanie Efthymiou, Ivana Nedic, Neda Mazaheri, Neda Mazaheri, Katharina Stumpfe, Reza Azizi Malamiri, Gholamreza Shariati, Gholamreza Shariati, Jawaher Zeighami, Nurettin Bayram, Seyed Kianoosh Naghibzadeh, Mohamad Tajik, Mehmet Yaşar, Ahmet Sami Güven, Farah Bibi, Tipu Sultan, Vincenzo Salpietro, Vincenzo Salpietro, Vincenzo Salpietro, Henry Houlden, Hüseyin Per, Hamid Galehdari, Bita Shalbafan, Yalda Jamshidi, Sebahattin Cirak, Sebahattin Cirak   +35 more
doaj   +1 more source

MAVS‐induced mitochondrial membrane remodeling [PDF]

The FEBS Journal, 2019
Mitochondrial membrane remodeling has been linked with several cellular processes including mitochondrial damage or apoptotic cell death and proceeds via yet poorly understood mechanisms. In this issue of The FEBS Journal, Hwang et al. used different forms of super resolution microscopy to study the formation of macromolecular complexes of ...
Hector Flores‐Romero, Ana J. García‐Sáez   +1 more
openaire   +2 more sources

Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy [PDF]

, 2011
Parkin, an E3 ubiquitin ligase implicated in Parkinson's disease, promotes degradation of dysfunctional mitochondria by autophagy. Using proteomic and cellular approaches, we show that upon translocation to mitochondria, Parkin activates the ubiquitin ...
Anh H. Pham, Anna M. Salazar, Chen, Ciechanover, Clark, Cox, David C. Chan, de Godoy, Deng, Deshaies, Ding, Gautier, Gegg, Geisler, Greene, Griparic, Kirkpatrick, Korolchuk, Kuroda, Lee, Matsuda, Michael J. Sweredoski, Narendra, Narendra, Narendra, Narendra, Natalie J. Kolawa, Nickie C. Chan, Okatsu, Ong, Pagliarini, Palacino, Pallanck, Park, Poole, Poole, Rappsilber, Robert L.J. Graham, Shimura, Song, Sonja Hess, Sou, Tai, Tanaka, Twig, Vives-Bauza, Yang, Yao, Ziviani, Ziviani   +49 more
core   +3 more sources

Cargo induces retromer-mediated membrane remodeling on membranes

Molecular Biology of the Cell, 2018
Endosomes serve as a central sorting station of lipids and proteins that arrive via vesicular carrier from the plasma membrane and the Golgi complex. At the endosome, retromer complexes sort selected receptors and membrane proteins into tubules or vesicles that bud off the endosome. The mature endosome finally fuses with the lysosome.
Purushothaman, Latha Kallur, Ungermann, Christian   +1 more
openaire   +2 more sources

Membrane remodelling during vaccinia virus morphogenesis [PDF]

Biology of the Cell, 2009
Background information. VACV (vaccinia virus) is one of the most complex viruses, with a size exceeding 300 nm and more than 100 structural proteins. Its assembly involves sequential interactions and important rearrangements of its structural components.Results.
Francisco Javier, Chichón, María Josefa, Rodríguez, Cristina, Risco, Alberto, Fraile-Ramos, José Jesús, Fernández, Mariano, Esteban, José L, Carrascosa   +6 more
openaire   +2 more sources

The Role of Electron Microscopy in Studying the Continuum of Changes in Membranous Structures during Poliovirus Infection

Viruses, 2015
Replication of the poliovirus genome is localized to cytoplasmic replication factories that are fashioned out of a mixture of viral proteins, scavenged cellular components, and new components that are synthesized within the cell due to viral manipulation/
Evan D. Rossignol, Jie E. Yang, Esther Bullitt   +2 more
doaj   +1 more source

Antibodies aggravate the development of ischemic heart failure [PDF]

, 2018
Heart-specific antibodies have been widely associated with myocardial infarction (MI). However, it remains unclear whether autoantibodies mediate disease progression or are a byproduct of cardiac injury. To disambiguate the role of immunoglobulins in MI,
Frantz, Stefan, Heinrichs, Margarete, Hofmann, Ulrich, Jocelyne, Demengeot, Keppner, Lea, Ramos, Gustavo, Rieckmann, Max   +6 more
core   +1 more source