Results 61 to 70 of about 1,558,886 (314)

The post-abscission midbody is an intracellular signaling organelle that regulates cell proliferation

Nature Communications, 2019
The midbody is a structure found between the two dividing daughter cells that recruits regulators during cell division, but its role after cell division is poorly understood.
Eric Peterman, Paulius Gibieža, Johnathon Schafer, Vytenis Arvydas Skeberdis, Algirdas Kaupinis, Mindaugas Valius, Xavier Heiligenstein, Ilse Hurbain, Graca Raposo, Rytis Prekeris   +9 more
doaj   +1 more source

Structure and Function of Basement Membrane.

Journal of Investigative Dermatology, 1982
Progress has been made in identifying and characterizing basement membrane macromolecules, including type IV collagen, laminin, a heparan sulfate proteoglycan and bullous pemphigoid antigen. Basement membrane contains a unique collagen, type IV collagen, which is formed of pro alpha 1(IV) (Mr = 185,000) and pro alpha 2(IV) (Mr = 170,000) chains.
Stanley, John R., Woodley, David T., Katz, Stephen I., Martin, George R.   +3 more
openaire   +2 more sources

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Single-molecule two- and three-colour FRET studies reveal a transition state in SNARE disassembly by NSF

Nature Communications
SNARE (soluble N-ethylmaleimide sensitive factor attachment protein receptor) proteins are the minimal machinery required for vesicle fusion in eukaryotes. Formation of a highly stable four-helix bundle consisting of SNARE motif of these proteins, drives
Sudheer K. Cheppali, Chang Li, Wenjing Xing, Ruirui Sun, Mengyi Yang, Yi Xue, Si-Yao Lu, Jun Yao, Shan Sun, Chunlai Chen, Sen-Fang Sui   +10 more
doaj   +1 more source

Structural Symmetry in Membrane Proteins [PDF]

Annual Review of Biophysics, 2015
Symmetry is a common feature among natural systems, including protein structures. A strong propensity toward symmetric architectures has long been recognized for water-soluble proteins, and this propensity has been rationalized from an evolutionary standpoint.
openaire   +3 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Structure of an F-type phage tail-like bacteriocin from Listeria monocytogenes

Nature Communications
F-type phage tail-like bacteriocins (PTLBs) are high-molecular-weight protein complexes exhibiting bactericidal activity and share evolutionary similarities with the tails of non-contractile siphoviruses. In this study, we present the atomic structure of
Zhiwei Gu, Xiaofei Ge, Jiawei Wang
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Structural stability and mass transfer properties of pressure retarded osmosis (PRO) membrane under high operating pressures

, 2015
The fabrication of new membrane that is able to produce stable high power density is essential for the development of pressure retarded osmosis (PRO) technology.
Li, Ye, Qi, S, Tang, C, Li, Y, Wang, Rong, Wang, R, Tang, Chuyang, Qi, Saren   +7 more
core   +1 more source

Rational design of chemical- and light-inducible cGAS activation based on mechanistic insights

Communications Biology
Cyclic GMP-AMP synthase (cGAS) plays a pivotal role in the cGAS-STING pathway as a DNA sensor that binds to double-stranded DNA (dsDNA) and subsequently induces type I interferon expression, thereby contributing significantly to the innate immune ...
Yiting Tang, Wenjuan Wang, Chunlai Chen
doaj   +1 more source