Results 111 to 120 of about 262,639 (307)
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
Evolution of membrane signaling and trafficking in plants [PDF]
Frontiers in Plant Science, 2013 Membrane proteins are essential determinants of many biological processes in plants. They function in metabolic processes, signal transduction, transport of small molecules and polymers across endo- and plasma membranes, and inter-compartmental trafficking of proteins, lipids, and cell wall components. During these highly integrative processes, dynamic
openaire +4 more sources
Molecular Aspects of Membrane Trafficking in Paramecium [PDF]
, 2003 Results achieved in the molecular biology of Paramecium have shed new light on its elaborate membrane trafficking system. Paramecium disposes not only of the standard routes (endoplasmic reticulum --> Golgi --> lysosomes or secretory vesicles; endo- and phagosomes --> lysosomes/digesting vacuoles), but also of some unique features, e.g.
Plattner, Helmut, Kissmehl, Roland
openaire +3 more sources
Rab35 GTPase and cancer: Linking membrane trafficking to tumorigenesis [PDF]
, 2018 International audienceBrief synopsis: Rab35 is a small GTPase that was recently reported to possess oncogenic activating mutations in human tumors. Conversely, Rab35 depletion inverts apico-basal cell polarity and promotes cell migration.
Shaughnessy, Ronan +3 more
core +1 more source
Journal of Lipid Research, 2001 The hypothesis of lipid domains in cellular plasma membranes is well established. However, direct visualization of the domains has been difficult. Here we report direct visualization of plasma membrane cholesterol microdomains modulated by agents that ...
Howard S. Kruth +5 more
doaj +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Chemical genetic dissection of membrane trafficking [PDF]
, 2017 The plant endomembrane system is an extensively connected functional unit for exchanging material between compartments. Secretory and endocytic pathways allow dynamic trafficking of proteins, lipids, and other molecules, regulating a myriad of ...
Norambuena Morales, Lorena +3 more
core +1 more source
Molecular basis for the assembly of the Vps5-Vps17 SNX-BAR proteins with Retromer
Nature CommunicationsRetromer mediates endosomal retrieval of transmembrane proteins in all eukaryotes and was first discovered in yeast in complex with the Vps5 and Vps17 sorting nexins (SNXs).
Kai-En Chen +10 more
doaj +1 more source
A Stress Response Monitoring Lipoprotein Trafficking to the Outer Membrane
mBio, 2019 Gram-negative bacteria produce lipid-anchored lipoproteins that are trafficked to their outer membrane (OM). These lipoproteins are essential components in each of the molecular machines that build the OM, including the Bam machine that assembles β ...
Kerrie L. May +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia +3 more
wiley +1 more source