Results 121 to 130 of about 262,474 (307)

Ezetimibe interferes with cholesterol trafficking from the plasma membrane to the endoplasmic reticulum in CaCo-2 cells

Journal of Lipid Research, 2007
Niemann-Pick C1-like 1 protein (NPC1L1) is the putative intestinal sterol transporter and the molecular target of ezetimibe, a potent inhibitor of cholesterol absorption.
F. Jeffrey Field, Kim Watt, Satya N. Mathur   +2 more
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Immunoglobulin Free Light Chains Trafficking Pathways

, 2012
INTRODUCTION: Monoclonal serum Free Light Chains (FLCs) are present in the serum and urine of many patients with plasma cell proliferation diseases. The physical-chemical characteristics of FLCs vary among patients and to date the different tissue damage
DI NOTO, Giuseppe, PAOLINI, Lucia, RICOTTA, Doris   +2 more
core  

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Intracellular trafficking of AQP2 in renal cells: from physiology to pathology

, 2012
The water channel Aquaporin 2 (AQP2) is responsible for the vasopressin (VP)-dependent water reabsorption occurring in the kidney during antidiuresis. X-linked nephrogenic diabetes insipidus (XNDI), a severe rare disease characterized by impaired urine-
PROCINO, Giuseppe, VALENTI, Giovanna, Barbieri C., Milano S. Carmosino M., SVELTO, Maria   +4 more
core  

Possible Roles of Membrane Trafficking Components for Lipid Droplet Dynamics in Higher Plants and Green Algae

Frontiers in Plant Science, 2019
Lipid droplets are ubiquitous dynamic organelles that contain neutral lipids surrounded by a phospholipid monolayer. They can store and supply lipids for energy metabolism and membrane synthesis.
Shuxian Huang, Liwen Jiang, Liwen Jiang, Xiaohong Zhuang   +3 more
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Hypoxia-stimulated membrane trafficking requires T-plastin

, 2017
Aim Traffic between the plasma membrane and the endomembrane compartments is an essential feature of eukaryotic cells. The secretory pathway sends cargoes from biosynthetic compartments to the plasma membrane.
Heidenreich, D., S. Naas, Katschinski, D. M., Lenz, C., J. Böttger, von Ahlen, M., Lutz, S., G. J. van Belle, Böttger, J., Möbius, W., van Belle, G., van Belle, G. J., K. Kröhnert, M. Wottawa, Zieseniss, A., Revelo, Natalia H., Katschinski, D., N. H. Revelo, W. Möbius, Rizzoli, S., S. O. Rizzoli, Urlaub, H., Rizzoli, S. O., Kröhnert, K., A. Zieseniss, Naas, S., M. von Ahlen, D. Heidenreich, H. Urlaub, D. M. Katschinski, Wottawa, M., Revelo, N., C. Lenz, S. Lutz   +33 more
core   +1 more source

LKB1/AMPK and PKA control ABCB11 trafficking and polarization in hepatocytes.

PLoS ONE, 2014
Polarization of hepatocytes is manifested by bile canalicular network formation and activation of LKB1 and AMPK, which control cellular energy metabolism.
László Homolya, Dong Fu, Prabuddha Sengupta, Michal Jarnik, Jean-Pierre Gillet, Lynn Vitale-Cross, J Silvio Gutkind, Jennifer Lippincott-Schwartz, Irwin M Arias   +8 more
doaj   +1 more source

A Paired RNAi and RabGAP Overexpression Screen Identifies Rab11 as a Regulator of β-Amyloid Production

Cell Reports, 2013
Alzheimer’s disease (AD) is characterized by cerebral deposition of β-amyloid (Aβ) peptides, which are generated from amyloid precursor protein (APP) by β- and γ-secretases. APP and the secretases are membrane associated, but whether membrane trafficking
Vinod Udayar, Virginie Buggia-Prévot, Rita L. Guerreiro, Gabriele Siegel, Naresh Rambabu, Amanda L. Soohoo, Moorthi Ponnusamy, Barbara Siegenthaler, Jitin Bali, AESG, Mikael Simons, Jonas Ries, Manojkumar A. Puthenveedu, John Hardy, Gopal Thinakaran, Lawrence Rajendran   +15 more
doaj   +1 more source