From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care
Molecular Oncology, EarlyView.Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard +8 more
wiley +1 more source
The role of membranes and membrane trafficking in RNA localization [PDF]
Biology of the Cell, 2005 AbstractEukaryotic cells possess highly sophisticated membrane trafficking pathways that define specific membrane domains and provide a means for moving vesicles between them (Mostov, Su, and ter Beest, 2003, Nat. Cell Biol. 5, 287–293). Here, I review recent data that indicate a role for membrane trafficking in mRNA localization.
openaire +2 more sources
Analysis of endocytosis at eisosomes [PDF]
, 2011 The yeast plasma membrane contains at least three microdomains – membrane compartment containing Pma1 (MCP), membrane compartment containing TORC2 (MCT) and membrane compartment containing Can1 (MCC).
Rehman, Michael, Rehman, M.
core
Syntaxin 16 and syntaxin 5 are required for efficient retrograde transport of several exogenous and endogenous cargo proteins [PDF]
, 2007 Retrograde transport allows proteins and lipids to leave the endocytic pathway to reach other intracellular compartments, such as trans-Golgi network (TGN)/Golgi membranes, the endoplasmic reticulum and, in some instances, the cytosol. Here, we have used
Falguières, Thomas +15 more
core +1 more source
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
Manipulation of lipid rafts in neuronal cells [PDF]
, 2010 Lipid rafts are specialized plasma membrane micro-domains highly enriched in cholesterol, sphingolipids and glycosylphosphatidylinositol (GPI) anchored proteins.
Eckert, Gunter P.
core
Sphingolipid trafficking - Sorted out? [PDF]
, 1992 Studies of intracellular membrane traffic have traditionally focused on the protein components of membranes, but what about lipids? Recent findings have drawn attention to the transport of one type of lipid, the sphingolipids.
Burger, K.N.J. +5 more
core +1 more source
Dynamic Organellar Mapping in yeast reveals extensive protein localization changes during ER stress
Nature CommunicationsSophisticated techniques are available for systematic studies of yeast cell biology. However, it remains challenging to investigate protein subcellular localization changes on a proteome-wide scale. Here, we apply Dynamic Organellar Mapping by label-free
Anna Platzek +4 more
doaj +1 more source
Membrane trafficking in neurodevelopmental disorders – new insight and therapeutic implications
Journal of Education, Health and SportIntroduction: Membrane trafficking processes are essential for cell viability and basic functions, as well as for interactions between the cell interior and the surrounding environment. Purpose: This article focuses on the review of specific subgroup
Małgorzata Pawłowicz
doaj +1 more source
Glutamatergic Receptor Trafficking and Delivery: Role of the Exocyst Complex
Cells, 2020 Cells comprise several intracellular membrane compartments that allow them to function properly. One of these functions is cargo movement, typically proteins and membranes within cells.
Matías Lira +5 more
doaj +1 more source