Results 101 to 110 of about 262,474 (307)

Evolution of membrane signaling and trafficking in plants [PDF]

Frontiers in Plant Science, 2013
Membrane proteins are essential determinants of many biological processes in plants. They function in metabolic processes, signal transduction, transport of small molecules and polymers across endo- and plasma membranes, and inter-compartmental trafficking of proteins, lipids, and cell wall components. During these highly integrative processes, dynamic
openaire   +4 more sources

Monoclonal antibody detection of plasma membrane cholesterol microdomains responsive to cholesterol trafficking

Journal of Lipid Research, 2001
The hypothesis of lipid domains in cellular plasma membranes is well established. However, direct visualization of the domains has been difficult. Here we report direct visualization of plasma membrane cholesterol microdomains modulated by agents that ...
Howard S. Kruth, Ina Ifrim, Janet Chang, Lia Addadi, Daniele Perl-Treves, Wei-Yang Zhang   +5 more
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Stability and membrane orientation of the fukutin transmembrane domain: a combined multiscale molecular dynamics and circular dichroism study

, 2010
The N-terminal domain of Fukutin-I has been implicated in the localization of the protein in the endoplasmic reticulum/Golgi apparatus. It has been proposed to mediate this through its interaction with the thinner lipid bilayers found in these ...
Khalid, Syma, Thomas J. Piggot, Philip T. F. Williamson, Syma Khalid, Leung, Yuk Ming, Yuk Ming Leung, Daniel A. Holdbrook, Holdbrook, Daniel A., Piggot, T, Marius, Phedra, Williamson, Phillip T.F., Phedra Marius   +11 more
core   +1 more source

Chemical genetic dissection of membrane trafficking [PDF]

, 2017
The plant endomembrane system is an extensively connected functional unit for exchanging material between compartments. Secretory and endocytic pathways allow dynamic trafficking of proteins, lipids, and other molecules, regulating a myriad of ...
Norambuena Morales, Lorena, Ricardo Tejos, Tejos, Ricardo, Lorena Norambuena   +3 more
core   +1 more source

Molecular Aspects of Membrane Trafficking in Paramecium [PDF]

, 2003
Results achieved in the molecular biology of Paramecium have shed new light on its elaborate membrane trafficking system. Paramecium disposes not only of the standard routes (endoplasmic reticulum --> Golgi --> lysosomes or secretory vesicles; endo- and phagosomes --> lysosomes/digesting vacuoles), but also of some unique features, e.g.
Plattner, Helmut, Kissmehl, Roland
openaire   +3 more sources

Molecular basis for the assembly of the Vps5-Vps17 SNX-BAR proteins with Retromer

Nature Communications
Retromer mediates endosomal retrieval of transmembrane proteins in all eukaryotes and was first discovered in yeast in complex with the Vps5 and Vps17 sorting nexins (SNXs).
Kai-En Chen, Vikas A. Tillu, Navin Gopaldass, Sudeshna Roy Chowdhury, Natalya Leneva, Oleksiy Kovtun, Juanfang Ruan, Qian Guo, Nicholas Ariotti, Andreas Mayer, Brett M. Collins   +10 more
doaj   +1 more source

A Stress Response Monitoring Lipoprotein Trafficking to the Outer Membrane

mBio, 2019
Gram-negative bacteria produce lipid-anchored lipoproteins that are trafficked to their outer membrane (OM). These lipoproteins are essential components in each of the molecular machines that build the OM, including the Bam machine that assembles β ...
Kerrie L. May, Kelly M. Lehman, Angela M. Mitchell, Marcin Grabowicz   +3 more
doaj   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

N-terminal arginines modulate plasma-membrane localization of Kv7.1/KCNE1 channel complexes

, 2011
Background and Objective: The slow delayed rectifier current (IKs) is important for cardiac action potential termination. The underlying channel is composed of Kv7.1 α-subunits and KCNE1 β-subunits.
Takac, Ina, Ehrlich, Joachim, Zenawit Girmatsion, Biliczki, Peter, Biliczki Peter, Stefan H Hohnloser, Stefan H. Hohnloser, Schwerthelm Christin, Hohnloser, Stefan H., Christin Schwerthelm, Girmatsion, Zenawit, Joachim R. Ehrlich, Hohnloser Stefan H., Ina Takac, Takac Ina, Peter Biliczki, Ehrlich Joachim R., Girmatsion Zenawit, Schwerthelm, Christin, Joachim R Ehrlich   +19 more
core   +1 more source