Results 81 to 90 of about 9,102,946 (306)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Enhanced antifouling and separation capabilities of polydopamine@Ce-MOF functionalized PES ultrafiltration membrane

npj Clean Water
The need for antifouling membranes is substantial due to fouling’s negative impact on the effectiveness and durability of ultrafiltration membranes.
Dana Kadadou, Thanigaivelan Arumugham, Lina Tizani, Shadi W. Hasan   +3 more
doaj   +1 more source

Predicting Transdermal Fentanyl Delivery Using Mechanistic Simulations for Tailored Therapy

Frontiers in Pharmacology, 2020
Transdermal drug delivery is a key technology for administering drugs. However, most devices are “one-size-fits-all”, even though drug diffusion through the skin varies significantly from person-to-person. For next-generation devices, personalization for
Thijs Defraeye, Flora Bahrami, Flora Bahrami, Lu Ding, Lu Ding, Riccardo Innocenti Malini, Alexandre Terrier, René M. Rossi   +7 more
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Biomimetic Approaches for Membrane Technologies

Separation & Purification Reviews, 2015
Membrane technology is the dominant process in water treatment. However, the operation cost of membranes cannot be decreased unless the amount of fouling, the “Achilles heel” of membranes, and energy consumed are cut. The high energy requirements in commercial nanofiltration, reverse osmosis and forward osmosis technologies lead researchers to develop ...
Sengur-Tasdemir, Reyhan, Aydin, Sevcan, Turken, Turker, Genceli, Esra Ates, Koyuncu, Ismail   +4 more
openaire   +2 more sources

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Dense membranes for oxygen and hydrogen separation (DEMOYS): project overview and first results [PDF]

, 2013
This paper provides an overview of objectives, structure and first results of the DEMOYS project, financially supported by the European Commission in the frame of the 7th FP Energy. The project started on May 1, 2010 and brings together fifteen Partners,
Jewulski, Janutz, M. Gindrat, P. Pinacci, Serra, José, Jarligo, M. O., L. Mancuso, Gindrat, M., E. Louradour, Serra Alfaro, José Manuel, Serra, J. M., Louradour, E., L. Wimbert, Louradour, Eric, Comite, Antonio, Mancuso, L., Chiesa, P., PRESTAT M., JEWULSKI J., Vassen, Robert, M.O. Jarligo, R. Vassen, P. Chiesa, E. Ivers-Tiffée, Chiesa, Paolo, Pinacci, Pietro, Ivers-Tiffée, E., Gindrat, Malko, SERRA J. M., JARLIGO M. O., J.M. Serra, Vassen, R., A. Comite, IVERS TIFFÉE E., PINACCI P., Comite, A., LOURADOUR E., Wimbert, L., GINDRAT M., Serra, J.M., Mancuso, Luca, COMITE A., J. Jewulski, VASSEN R., Jarligo, M.O., Pinacci, P., Jewulski, J., Jarligo, Maria Ophelia, MANCUSO L., Prestat, M., M. Prestat, Prestat, Michel, WIMBERT L., Ivers-Tiffée, Ellen, Wimbert, Lars   +53 more
core   +1 more source

Composite Aramid Membranes with High Strength and pH-Response

, 2021
The pH-responsive membrane is a new wastewater treatment technology developed in recent years. In this paper, a novel film with intelligent pH-responsiveness was first prepared by blending functional gates comprised of hydrolyzed aramid nanofibers (HANFs)
Zhenzhu Huang, Xuefeng Gui, Shi Li, Xiao Wang, Shudong Lin, Yuanyuan Tu, Jiwen Hu   +6 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source