Results 71 to 80 of about 9,102,946 (306)

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Supramolecular Membranes for Liquid Separation [PDF]

open access: yes, 2022
Introducing the advances of functional membranes along with their design and environmental applications.
Zhao, S, Yi, G, Samadi, A, Fu, Q
core  

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Zeolite membrane with sub-nanofluidic channels for superior blue energy harvesting

open access: yesNature Communications
Blue energy, a clean energy source derived from salinity gradients, has recently drawn increased research attention. It can be harvested using charged membranes, typically composed of amorphous materials that suffer from low power density due to their ...
Ruicong Wei   +7 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

3D hierarchical aquaporin-like nanoporous graphene membrane with engineered tripartite nanochannels for efficient oil/water separation

open access: yesnpj Clean Water
The aqueous system is being polluted by the untreated direct discharge of industrial oily wastewater into the ecosystem. Due to its low cost, energy economy, and sustainability, the advanced membrane filtration method is regarded as one of the best ...
Hanaa M. Hegab   +6 more
doaj   +1 more source

Structural evolution and strain generation of derived-Cu catalysts during CO2 electroreduction

open access: yesNature Communications, 2022
Copper catalysts derived from oxidized precursors typically exhibit high selectivity for CO2 electroreduction to multicarbon products, yet the influencing factors that control the selectivity need further investigation.
Qiong Lei   +10 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

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