Results 141 to 150 of about 385,015 (245)

Real-World Outcomes of Fusion-Directed Targeted Therapy in Advanced Non-Small Cell Lung Cancer Harboring Actionable Gene Fusions. [PDF]

Int J Mol Sci
Delgado Leon F, de Armas SA, Molina M, Morales EG, Fernandez-Gomez M, Raez LE.   +5 more
europepmc   +1 more source

YTHDC1 Orchestrates Glucose and Glutamate Rewiring to Overcome Lethal Metabolic Stress in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Lai et al. find that m6A reader YTHDC1 is specifically overexpressed in triple‐negative breast cancer (TNBC) and orchestrates glucose and glutamine metabolism in an m6A‐dependent manner to confer robust adaptability to lethal metabolic stress. Leveraging YTHDC1 knockdown‐induced metabolic vulnerability, an ATF4 mRNA‐targeted nanotherapy is developed to
Zheng‐Hao Lai, Yi Wang, Na‐Na Li, Ling Zeng, Renzhong Liu, Xue Li, Cheukfai Li, Xin‐Yu Ma, Wenkui Fu, Yingsen Tang, Jinjin Chen, Ning Liao, Man‐Li Luo   +12 more
wiley   +1 more source

Radiation‐Triggered Chemokine‐Secreting Probiotics for Boron Neutron Capture Therapy Based Radioimmunotherapy

Advanced Science, EarlyView.
Engineered Escherichia coli Nissle 1917 with a tannic acid‐mediated BPA coating enables tumor‐targeted boron delivery for BNCT. The low‐level incidental radiation generated during BNCT activate a RecA‐driven circuit to induce CXCL10, while radiation‐enhanced bacterial colonization triggers in situ vaccination and systemic antitumor immunity.
Yang Liu, Yuzhong Qian, Shaobo Huang, Bingbing Li, Yue Yu, Xiang Cheng, Chang Chen, Jiheng Wang, Maosong Yang, Lizheng Liang, Xiancai Meng, Zhigang Liu   +11 more
wiley   +1 more source

DNA-dependent protein kinase inhibition as a radiosensitizer in rectal cancer: toxicity must be evaluated in the context of organ preservation. [PDF]

J Gastrointest Oncol
Ravella R, Zambare W, Roth O'Brien D, Romesser PB.   +3 more
europepmc   +1 more source

Near‐Infrared Fluorescent PROTAC Enables Theranostic Imaging and Selective Tau Degradation in Alzheimer's Disease

Advanced Science, EarlyView.
Here, we report a novel NIR fluorescent PROTAC platform that enables real‐time imaging and targeted degradation of Alzheimer's p‐Tau. Our lead compound effectively clears p‐Tau, reduces APP/Aβ, and alleviates cognitive deficits in AD mice. This work demonstrates a theranostic strategy for visualizing degradation and developing next‐generation AD ...
Ziwei Ren, Qian Yue, Ning Gao, Qiu‐Lian Hao, Yan Huo, Chuchu Li, Xinyue Leng, Lu‐Lu Sun, Maggie Pui Man Hoi, Hai‐Hao Han, Mingliang Ma, Xu‐Wen Li   +11 more
wiley   +1 more source

Impact of early albumin therapy on 28-day survival in ICU patients with septic shock concurrent hypoalbuminemia: a retrospective analysis of combined clinical datasets. [PDF]

World J Emerg Med
Lin F, Huang T, Zhang J, Liu S, Yang Z.
europepmc   +1 more source

Single‐Cell Profiling Reveals Clonally Expanded CX3CR1+ T Cells in Anti‐NMDA Receptor Encephalitis

Advanced Science, EarlyView.
CX3CR1+ T cells are associated with peripheral and central immune alterations in anti‐NMDA receptor encephalitis (NMDAR‐E). They show potential responsiveness to GluN1 (NR1) peptides, potential interactions with peripheral B cells, clonal expansion, increased CD137/CD154 expression, and inflammatory cytokine production. Their preferential cerebrospinal
Lin Yan, Erdi Zhang, Yuwen Ma, Zirui Meng, Sisi Li, Yimeng Ren, Xiaohe Tian, Yangyi He, Giuseppe Battaglia, Dong Zhou, Yun Liao, Binwu Ying, Jinmei Li, Minjin Wang   +13 more
wiley   +1 more source

Publisher Correction: Progressive plasticity during colorectal cancer metastasis. [PDF]

Nature
Moorman A, Benitez EK, Cambuli F, Jiang Q, Mahmoud A, Lumish M, Hartner S, Balkaran S, Bermeo J, Asawa S, Firat C, Saxena A, Wu F, Luthra A, Burdziak C, Xie Y, Sgambati V, Luckett K, Li Y, Yi Z, Masilionis I, Soares K, Pappou E, Yaeger R, Kingham TP, Jarnagin W, Paty PB, Weiser MR, Mazutis L, D'Angelica M, Shia J, Garcia-Aguilar J, Nawy T, Hollmann TJ, Chaligné R, Sanchez-Vega F, Sharma R, Pe'er D, Ganesh K.   +38 more
europepmc   +1 more source

Asymmetric Fluorinated Spiro Hole‐Transport Materials Enabled by a Rapid Core‐Forming Strategy for Blade‐Coated Perovskite Solar Cells

Advanced Science, EarlyView.
Facile synthesis of asymmetric fluorinated spiro‐type HTMs combined with blade‐coating fabrication and vacuum‐assisted crystallization enables high‐efficiency PSCs with PCEs of 24.49% (0.09 cm2) and 23.28% (1.00 cm2), along with excellent stability.
Kun‐Mu Lee, Xiu‐Ping Lin, Ya‐Ho Chang, Cheng‐Ting Tsai, Pei‐Chen Chu, Yu‐Hsun Chen, Wei‐Hao Chiu, Yu‐Che Lin, Sie‐Rong Li, Hsiao‐Chi Hsieh, Kang‐Ling Liau, Shih‐I. Lu, Chih‐Min Wang, Yan‐Duo Lin   +13 more
wiley   +1 more source

Radiotherapy Modality and Primary Tumor Type as Determinants of Outcomes in Brain Metastases: A Retrospective Study of 734 Patients. [PDF]

Medicina (Kaunas)
Hnidakova L, Pagacova A, Kristkova S, Svancara J, Hynkova L, Pospisil P, Belanova R, Maistryszinova J, Lakomy R, Prochazka T, Vrzal M, Sana J, Jancalek R, Smrcka M, Kolouskova I, Moran L, Prochazkova K, Andraskova V, Garcic J, Slampa P, Fadrus P, Kazda T.   +21 more
europepmc   +1 more source