Results 151 to 160 of about 385,015 (245)

Programmable Guest‐Induced 5‐Phase‐Transition Topological Reconstructions of Cobalt Formate Metal–Organic Frameworks

Advanced Science, EarlyView.
A reversible five‐phase topological cycle is achieved in a minimalist cobalt formate metal–organic framework. The amorphous phase functions as a programmable reactive hub, selectively reconstructing into four distinct crystalline architectures through cationic templates, humidity, or CO2.
Zhiyu Tao, Jingjian Li, Jing Ling, Tianxiang Chen, Wing‐Yiu Yu, Cong Lin, Tsz Woon Benedict Lo   +6 more
wiley   +1 more source

Molecular and Clinical Determinants of Targeted Therapy Treatment in Biliary Tract Cancer. [PDF]

Clin Cancer Res
Cowzer D, Walch H, Atri P, Shah F, Huq R, Thummalapalli R, Nagib F, Varghese A, Khalil DN, Park W, Rousseau B, Cercek A, Erinjeri J, Yeh R, Do RK, Basturk O, Shia J, Chakravarty D, Berger MF, Schultz N, Gonen M, O'Reilly EM, Jarnagin W, Abou-Alfa GK, Solit DB, Chatila WK, Harding JJ.   +26 more
europepmc   +1 more source

Helicobacter pylori‐Induced Persistent IGF2BP1 Activation Promotes Ferroptosis Resistance in Gastric Tumorigenesis

Advanced Science, EarlyView.
Helicobacter pylori infection induces sustained upregulation of the RNA‐binding protein IGF2BP1 in gastric epithelial cells, establishing a persistent epitranscriptomic program. IGF2BP1 stabilizes SLC7A11 mRNA in an m6A‐dependent manner to suppress ferroptosis and promote epithelial survival under oxidative stress. Pharmacological inhibition of IGF2BP1
Jing Ning, Xin Guan, Xinyu Hao, Jing Zhang, Deyao Li, Ying Xiong, Wenlin Zhang, Xiurui Han, Yanfei Lang, Meiling Zhou, Mengjie Yang, Zhi Huang, Tinghui Qu, Ming Zu, Qiao Meng, Weiwei Fu, Fengmin Lu, Jing Zhang, Xiangmei Chen, Tong Liu, Shigang Ding   +20 more
wiley   +1 more source

Integrated clinicogenomic analysis reveals the evolution and metastatic tropisms of advanced colorectal cancer. [PDF]

Cancer Cell
Manca P, Walch H, Xu J, Small N, Kris A, Seffar E, Richards A, Xue T, Price A, Donoghue MTA, Fong C, Waters M, Jee J, Deshmukh SK, Sledge GW, Malla M, Cercek A, Saltz L, Segal NH, Stadler ZK, Nusrat M, Foote MB, Desai A, Chalasani S, Rao D, Connell L, Do RKG, Ganesh K, Weiser MR, Berger MF, Solit DB, Shia J, Vakiani E, Garcia-Aguilar J, Schultz N, Sanchez-Vega F, Chatila WK, Yaeger R.   +37 more
europepmc   +1 more source

Spatiotemporally Controlled Sequential Chemo‐Immunotherapy Activates Pyroptosis for Robust Anti‐Tumor Immunotherapy

Advanced Science, EarlyView.
A glutathione and ultrasound dual‐responsive cerasome achieves sequential co‐delivery of gemcitabine and BMS1166 in tumors. Chemotherapy priming followed by on‐demand PD‐L1 blockade synergistically amplifies anti‐tumor immunity, inhibiting primary tumor growth, distant metastasis and inducing durable immune memory.
Suhui Sun, Ruiqi Wu, Qingshuang Tang, Yunli Xu, Wanrui Shi, Mengxin Wang, Haonan Wang, Yan Luo, Cheng Ma, Xiaolong Liang   +9 more
wiley   +1 more source

Correction: MCL-1 as a tumor microenvironment-linked survival node in cholangiocarcinoma. [PDF]

Front Oncol
Hashida H, Kobayashi A, Akagami M, Okamoto T, Tanaka H.   +4 more
europepmc   +1 more source

Memorial

The International Tinnitus Journal, 2016
openaire   +2 more sources

Detaching Photosensitive Nanoparticles from Cells Prevents Them from Remaining in Cells after Photoporation

Advanced Science, EarlyView.
Phenylboronic acid‐functionalized gold nanoparticles reversibly attach to cell‐surface glycans, enhancing photoporation‐mediated intracellular delivery. After irradiation, ATP competitively disrupts the boronic ester interactions and removes cell‐associated nanoparticles, markedly reducing residual gold.
Tao Lu, Mina Nikolić, Baihao Huang, Deep Punj, Herlinde De Keersmaecker, Thibaut Van Acker, Wenjia Xie, Florian Vanlauwe, Phillip Blondeel, Liesl De Graeve, Félix Sauvage, Ranhua Xiong, Chaobo Huang, Frank Vanhaecke, Kevin Braeckmans, Stefaan C. De Smedt   +15 more
wiley   +1 more source

Effects of two different perineal preparations before vaginal birth on maternal and neonatal infections and hospital resources: A randomized controlled trial. [PDF]

Eur J Midwifery
Huang TY, Chen LL, Peng FS, Chu FY, Gau ML.   +4 more
europepmc   +1 more source

Sonogenetics Nanomedicine Activates the cGAS‐STING Pathway for Immunotherapy of Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
A HER3‐targeted sonogenetic lipid nanoparticle platform is developed for triple‐negative breast cancer therapy. An AI‐designed miniprotein inhibits HER3 signaling, while TRPV4 and NFAT‐responsive IL‐15 plasmids enable ultrasound‐controlled calcium signaling and cytokine expression. The system induces Ca2+ overload, ROS generation, mitochondrial damage,
Junya Song, Yan Liu, Shifeng Zhao, Cheng Zhu, Hongchang Guo, Jin Chang, Jun Kang   +6 more
wiley   +1 more source