Results 91 to 100 of about 1,222,784 (265)

Impact of Plasma p‐tau181 on Cognition, Motor Phenotypes, and Disease Course in ALS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Phosphorylated tau181 (p‐tau181), an Alzheimer's disease biomarker, was recently evaluated in amyotrophic lateral sclerosis (ALS). We investigated plasma p‐tau181 in 202 ALS/ALS‐FTD patients and 94 healthy controls, assessing cognitive performance, motor function, and longitudinal dynamics.
Elisabeth Kasper, Annaliis Lehto, Nina Nordmann, Oliver Peters, Julian Hellmann, Josef Priller, Eike Jakob Spruth, Gabor C. Petzold, Ina Vogt, Patrick Weydt, Sarah Bernsen, Elisabeth Dinter, Björn Falkenburger, René Günther, Emrah Düzel, Wenzel Glanz, Matthis Synofzik, Lukas Beichert, Annika Spottke, Michael Wagner, Frederic Brosseron, Matthias C. Schmid, Anja Schneider, Stefan Teipel, Johannes Prudlo, Andreas Hermann   +25 more
wiley   +1 more source

Stepwise approach to alzheimer’s disease diagnosis in primary care using cognitive screening, risk factors, neuroimaging and plasma biomarkers

Scientific Reports
Early identification of Alzheimer’s disease (AD) pathology is essential for timely intervention, particularly in primary care. We evaluated the diagnostic performance of a scalable, multimodal framework in a real-world, population-based cohort.
Miren Altuna, Maite García-Sebastián, Raffaela Cipriani, Estibaliz Capetillo-Zarate, Elena Alberdi, Ainara Estanga, Mirian Ecay-Torres, Ane Iriondo, Jon Saldias, Marta Cañada, Carolina López, Maria Arriba, Mikel Tainta, Pablo Martínez-Lage   +13 more
doaj   +1 more source

Memory of a memory

, 2016
A collective memory project and digital online archive derived from public call-out in collaboration with the Bluecoat gallery and LOOK International Photography Festival, Liverpool, England.\ud \ud \ud This paper investigates the process by which photographs prompt memories, the ‘distance’ involved in the actual reading of images, (both physical &
openaire  

Metabolic and Microvascular Risk Factors Associated With Brain Health in Type 1 Diabetes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT We examined relationships between metabolic factors, microvascular complications, and brain health in adults with type 1 diabetes. Fifty‐one adults were assessed for metabolic risk factors, microvascular complications, and cognitive function, with a subset completing brain MRI.
Jihyun Park, Emily J. Koubek, Richard Beare, Lynn Ang, Brian C. Callaghan, Rodica Pop‐Busui, Eva L. Feldman, Evan L. Reynolds   +7 more
wiley   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Relationships between blood pressure indicators and fluid biomarkers of brain aging in functionally intact older adults

Alzheimer’s Research & Therapy
Background Dementia risk is significantly shaped by cardiovascular health, with elevated blood pressure emerging as a key risk factor for adverse brain aging.
Anna M. VandeBunte, Bailey L. Ortiz, Emily W. Paolillo, Rowan Saloner, Valentina Diaz, Shubir Dutt, Claire J. Cadwallader, Coty Chen, Argentina Lario Lago, Julio C. Rojas, Brandon Chan, Isabel Sible, Joel H. Kramer, Kaitlin B. Casaletto   +13 more
doaj   +1 more source

Addressing gender-based violence through policy implementation: Key stakeholders and survivors’ perceptions in a selected university in South Africa

Interdisciplinary Journal of Sociality Studies
Universities have been stricken by gender-based violence (GBV). The high prevalence of GBV within universities is clear evidence of attacks on educational settings. To address GBV, universities have adopted policies that focus on deterring its occurrence.
Memory Gwiza, Eleanor Alvira Hendricks
doaj   +1 more source

White Matter Microstructural Abnormalities in Neonatal Onset Genetic Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Recent evidence indicates that epilepsy is associated with abnormal white matter. If seizures alter white matter, then the impact upon network function, epileptogenesis, and cognition could be pronounced in neonates undergoing rapid developmental myelination. Neonates with epilepsy due to nonstructural genetic causes provide a unique
Amanda G. Sandoval Karamian, Tianjia Zhu, Hao Huang, Shavonne L. Massey, Mark P. Fitzgerald, Darshana Parikh, Arastoo Vossough, Ingo Helbig, Nicholas S. Abend   +8 more
wiley   +1 more source

Application of nanocalcium materials in heavy metal-stressed soils: benefit, risk and biomonitoring for sustainable remediation - a review

Frontiers in Environmental Science
The intensification of agriculture, mining and industrialization has led to an increase in heavy metal contamination of soil with long-term risks to food safety and human health.
Oluwatobi Esther Barachiah, Tekere Memory   +1 more
doaj   +1 more source

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs, Marcel Naumann, Annaliis Lehto, Hanna Schön, Jens Kurth, Johannes Prudlo, Andreas Hermann, Elisabeth Kasper   +7 more
wiley   +1 more source