Results 121 to 130 of about 3,006,221 (300)

Unaltered empathy-related behaviors in Williams–Beuren syndrome mouse models

Molecular Brain
Williams–Beuren Syndrome (WBS), a neurodevelopmental disorder caused by a heterozygous microdeletion at chromosome 7q11.23, is characterized by hypersociability and enhanced affective empathy.
Dahm So, Hye Lim Cha, Sua Lee, Sowon Kim, Eunsu Yoo, Sehoon Keum   +5 more
doaj   +1 more source

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

Spatial and Volumetric Characteristics of Glioblastoma: Associations With Clinical Presentation and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We aim to comprehensively analyze how regional tumor and edema characteristics are associated with clinical presentations and survival outcomes in a large cohort of glioblastoma patients. Methods Patients with IDH‐wildtype glioblastoma who received brain MRI from 2010 to 2023 were included.
Daniel J. Zhou, Marc Jaskir, Julian Gal, Yombe Fonkeu, Christos Davatzikos, MacLean P. Nasrallah, Jose Garcia, Rubo Xing, Stephen J. Bagley, Arati Desai, Richard E. Phillips, Steven Tobochnik, Colin A. Ellis, James J. Gugger, Nishant Sinha, Joel M. Stein, Kathryn A. Davis   +16 more
wiley   +1 more source

Stepwise approach to alzheimer’s disease diagnosis in primary care using cognitive screening, risk factors, neuroimaging and plasma biomarkers

Scientific Reports
Early identification of Alzheimer’s disease (AD) pathology is essential for timely intervention, particularly in primary care. We evaluated the diagnostic performance of a scalable, multimodal framework in a real-world, population-based cohort.
Miren Altuna, Maite García-Sebastián, Raffaela Cipriani, Estibaliz Capetillo-Zarate, Elena Alberdi, Ainara Estanga, Mirian Ecay-Torres, Ane Iriondo, Jon Saldias, Marta Cañada, Carolina López, Maria Arriba, Mikel Tainta, Pablo Martínez-Lage   +13 more
doaj   +1 more source

MOGAD Is the Most Common Cause of Isolated Optic Neuritis in Children

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives The study aimed to characterize the clinical features, etiologies, and outcomes of isolated, first‐time pediatric ON in the post‐MOG‐IgG era. Methods This was a single‐center retrospective cohort study at Texas Children's Hospital of patients diagnosed with first‐time ON between 2018–2024, with follow‐up data collected through 2025.
Chaitanya Aduru, Akansha Chandrasekar, Kyla Blasingame, Jonathan Rosen, Jesse M. Levine, Karla Salazar, Madhuri Chilakapati, Rod Foroozan, Victoria Hardwick, Jonathan M. Yarimi, Nikita Shukla, Timothy E. Lotze, Kristen S. Fisher, Alexander J. Sandweiss   +13 more
wiley   +1 more source

Memory and consciousness [PDF]

, 2011
O'Connor, Akira Robert, Moulin, Chris, Cohen, Gillian   +2 more
core   +2 more sources

Relationships between blood pressure indicators and fluid biomarkers of brain aging in functionally intact older adults

Alzheimer’s Research & Therapy
Background Dementia risk is significantly shaped by cardiovascular health, with elevated blood pressure emerging as a key risk factor for adverse brain aging.
Anna M. VandeBunte, Bailey L. Ortiz, Emily W. Paolillo, Rowan Saloner, Valentina Diaz, Shubir Dutt, Claire J. Cadwallader, Coty Chen, Argentina Lario Lago, Julio C. Rojas, Brandon Chan, Isabel Sible, Joel H. Kramer, Kaitlin B. Casaletto   +13 more
doaj   +1 more source

Addressing gender-based violence through policy implementation: Key stakeholders and survivors’ perceptions in a selected university in South Africa

Interdisciplinary Journal of Sociality Studies
Universities have been stricken by gender-based violence (GBV). The high prevalence of GBV within universities is clear evidence of attacks on educational settings. To address GBV, universities have adopted policies that focus on deterring its occurrence.
Memory Gwiza, Eleanor Alvira Hendricks
doaj   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Application of nanocalcium materials in heavy metal-stressed soils: benefit, risk and biomonitoring for sustainable remediation - a review

Frontiers in Environmental Science
The intensification of agriculture, mining and industrialization has led to an increase in heavy metal contamination of soil with long-term risks to food safety and human health.
Oluwatobi Esther Barachiah, Tekere Memory   +1 more
doaj   +1 more source