Results 81 to 90 of about 4,743,433 (368)

Polyfunctional CD8+CD226+RUNX2hi effector T cells are diminished in advanced stages of chronic lymphocytic leukemia

open access: yesMolecular Oncology, EarlyView.
CD226+CD8+ T cells express elevated levels of RUNX2, exhibit higher proliferation capacity, cytokines and cytolytic molecules expression, and migratory capacity. In contrast, CD226−CD8+ T cells display an exhausted phenotype associated with the increased expression of co‐inhibitory receptors and impaired effector functions.
Maryam Rezaeifar   +4 more
wiley   +1 more source

Protocol for the Tallaght University Hospital Institute for Memory and Cognition-Biobank for Research in Ageing and Neurodegeneration

open access: yesBMJ Open, 2023
Introduction Alzheimer’s disease and other dementias affect >50 million individuals globally and are characterised by broad clinical and biological heterogeneity. Cohort and biobank studies have played a critical role in advancing the understanding of
Eimear Connolly   +22 more
doaj   +1 more source

Misalignment challenges when integrating security requirements into mobile banking application development [PDF]

open access: yes, 2016
This study identifies and explores the core challenge faced when integrating security requirements into the mobile application software development life cycle. Studies on key issues in Information Systems (IS) have been on-going in the past decades, with
Machiridza, Memory
core   +1 more source

Cystatin A promotes the antitumor activity of T helper type 1 cells and dendritic cells in murine models of pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Pancreatic ductal adenocarcinoma (PDAC) is a disease with very poor prognosis due to therapeutic limitations. We investigated the antitumor effects of cystatin A (CSTA) in PDAC murine models. We are first to confirm that CSTA enhances T helper type 1‐mediated antitumor effects through promotion of dendritic cells and M1 macrophage activity. CSTA can be
Alessandro Nasti   +8 more
wiley   +1 more source

Problems Facing Disabled People in Malawi : A Critical Reflection on My Encounter with a Disabled Woman in a Rural Area in Malawi

open access: yesJournal of Comparative Social Work, 2015
This critical reflection is based on my encounter with a disabled woman in a district in Malawi, and how I have reflected and analyzed the encounter using social work theories.
Memory J. Tembo
doaj  

A Dual Memory Structure for Efficient Use of Replay Memory in Deep Reinforcement Learning [PDF]

open access: yesarXiv, 2019
In this paper, we propose a dual memory structure for reinforcement learning algorithms with replay memory. The dual memory consists of a main memory that stores various data and a cache memory that manages the data and trains the reinforcement learning agent efficiently. Experimental results show that the dual memory structure achieves higher training
arxiv  

The Ruin as Memorial – The Memorial as Ruin [PDF]

open access: yesPerformance Research, 2015
The ruin allows for a visualization of different forms of mourning: we mourn loss, death, decay and destruction; man-made and natural catastrophes; humanity’s futile and successful attempts to master nature; and nature’s indifference to humans and their cruelty against one another.
openaire   +2 more sources

Integration of single‐cell and bulk RNA‐sequencing data reveals the prognostic potential of epithelial gene markers for prostate cancer

open access: yesMolecular Oncology, EarlyView.
Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley   +1 more source

Conformally equivariant quantization: Existence and uniqueness [PDF]

open access: yes, 1999
We prove the existence and the uniqueness of a conformally equivariant symbol calculus and quantization on any conformally flat pseudo-Riemannian manifold $(M,\rg)$.
André Lichnerowicz   +5 more
core   +5 more sources

Peripheral blood leukocyte signatures as biomarkers in relapsed ovarian cancer patients receiving combined anti‐CD73/anti‐PD‐L1 immunotherapy in arm A of the NSGO‐OV‐UMB1/ENGOT‐OV30 trial

open access: yesMolecular Oncology, EarlyView.
Using mass cytometry, we analyzed serial blood samples from patients with relapsed epithelial ovarian cancer (EOC) treated with oleclumab–durvalumab combination immunotherapy in the NSGO‐OV‐UMB1/ENGOT‐OV30 trial. Our analysis identified potential predictive, monitoring, and response biomarkers detectable through liquid biopsy. These findings facilitate
Luka Tandaric   +11 more
wiley   +1 more source

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