Results 61 to 70 of about 947,925 (355)

Cathepsin D regulates cerebral Aβ42/40 ratios via differential degradation of Aβ42 and Aβ40

Alzheimer’s Research & Therapy, 2020
Background Cathepsin D (CatD) is a lysosomal protease that degrades both the amyloid β-protein (Aβ) and the microtubule-associated protein, tau, and has been genetically linked to late-onset Alzheimer disease (AD).
Caitlin N. Suire, Samer O. Abdul-Hay, Tomoko Sahara, Dongcheul Kang, Monica K. Brizuela, Paul Saftig, Dennis W. Dickson, Terrone L. Rosenberry, Malcolm A. Leissring   +8 more
doaj   +1 more source

The I in Autism:severity and social functioning in Autism is related to self-processing [PDF]

, 2017
It is well established that children with autism spectrum disorder (ASD) show impaired understanding of others and deficits within social functioning. However, it is still unknown whether self-processing is related to these impairments and to what extent
Ballantyne, Carrie, Branigan, Holly P., Cunningham, Sheila J., Gillespie-Smith, Karri, Turk, David J.   +4 more
core   +7 more sources

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

The effect of a training programme stimulating language functions on Alzheimer-type dementia and maintenance of language skills

Aktualności Neurologiczne, 2017
In dementia of the Alzheimer’s type, memory and language impairments coexist, occur early and aggravate with time. The aim of this study was to assess the effect of our proprietary language function stimulating programme on cognitive functions and the ...
Andrzej Potemkowski, Marta Wąsik, Marcin Ratajczak   +2 more
doaj   +1 more source

Kikuchi–Fujimoto disease associated with the central nervous system in children

Pediatric Discovery, 2023
The clinical data of patients with Kikuchi–Fujimoto disease (KFD) combined with the involvement of the central system is limited, particularly for children.
Yuyao Huang, Xinpeng Wang, Ling Wang, Juan Wang, Chengbing Tan, Min Cheng, Yan Jiang, Li Jiang   +7 more
doaj   +1 more source

Musiikki muistisairaan vanhuksen hyvinvoinnin edistäjänä : Hoitonetti [PDF]

, 2013
Iäkkäämpien ikäryhmien osuuden kasvaessa myös muistisairauksia sairastavien määrä moninkertaistuu. Muistisairaudet ovat isoin riskitekijä, joka johtaa iäkkään ihmisen pois kodistaan ympärivuorokautiseen hoitopaikkaan.
Haapamäki, Tiina
core  

The influence of working memory load on response inhibition in children with attention-deficit/hyperactivity disorder or reading disorder [PDF]

, 2011
The aim of the present study was to examine the relationship between response inhibition and working memory in 8-12-year-old children with attention-deficit/hyperactivity disorder (ADHD; n = 19), reading disorder (RD; n = 17), ADHD + RD (n = 21), and ...
Roeyers, Herbert, Van De Voorde, Séverine, Verte, Sylvie, Wiersema, Roeljan   +3 more
core   +2 more sources

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Inhibition of cystathionine β-synthase promotes apoptosis and reduces cell proliferation in chronic myeloid leukemia

Signal Transduction and Targeted Therapy, 2021
Increased endogenous hydrogen sulfide (H2S) level by cystathionine β-synthase (CBS) has been shown to closely relate tumorigenesis. H2S promotes angiogenesis, stimulates bioenergy metabolism and inhibits selective phosphatases.
Dan Wang, Huan Yang, Yun Zhang, Rong Hu, Dongjie Hu, Qunxian Wang, Yannan Liu, Mingjing Liu, Zijun Meng, Weihui Zhou, Weihong Song   +10 more
doaj   +1 more source

Sex differences in HIV effects on visual memory among substance-dependent individuals [PDF]

, 2016
HIV’s effects on episodic memory have not been compared systematically between male and female substance-dependent individuals. We administered the Brief Visuospatial Memory Test–Revised (BVMT–R) to 280 substance-dependent HIV+ and HIV– men and women ...
Gonzalez, Raul, Keutmann, Michael K., Maki, Pauline M., Martin, Eileen M., Rubin, Leah H., Vassileva, Jasmin   +5 more
core   +2 more sources