Results 61 to 70 of about 825,210 (300)

Anti-TIGIT differentially affects sepsis survival in immunologically experienced versus previously naive hosts

JCI Insight, 2021
Mounting evidence suggests that the balance of T cell costimulatory and coinhibitory signals contributes to mortality during sepsis. Here, we identified a critical role of the coinhibitory molecule T cell Ig and ITIM domain (TIGIT) in regulating sepsis ...
Yini Sun, Jerome C. Anyalebechi, He Sun, Tetsuya Yumoto, Ming Xue, Danya Liu, Zhe Liang, Craig M. Coopersmith, Mandy L. Ford   +8 more
doaj   +1 more source

Thalidomide with blockade of co-stimulatory molecules prolongs the survival of alloantigen-primed mice with cardiac allografts

BMC Immunology, 2020
Background Miscellaneous memory cell populations that exist before organ transplantation are crucial barriers to transplantation. In the present study, we used a skin-primed heart transplantation model in mouse to evaluate the abilities of Thalidomide ...
Maoshu Zhu, Yunhan Ma, Kai Tan, Liyi Zhang, Zhaowei Wang, Yongsheng Li, Yingyu Chen, Junjun Guo, Guoliang Yan, Zhongquan Qi   +9 more
doaj   +1 more source

Anomalous diffusion and generalized Sparre-Andersen scaling

, 2009
We are discussing long-time, scaling limit for the anomalous diffusion composed of the subordinated L\'evy-Wiener process. The limiting anomalous diffusion is in general non-Markov, even in the regime, where ensemble averages of a mean-square ...
B. Dybiec, Chechkin A. V., Dybiec B., Dybiec B., Dybiec B. Gudowska-Nowak E., E. Gudowska-Nowak, Feller W., Goel N. S., Metzler R., Metzler R., Metzler R., Podlubny I., Redner S., Shlesinger M. F., Sokolov I., Sparre Andersen E., Sparre Andersen E., van Kampen N. G.   +17 more
core   +1 more source

T-Bet and Eomes Regulate the Balance between the Effector/Central Memory T Cells versus Memory Stem Like T Cells [PDF]

, 2013
Memory T cells are composed of effector, central, and memory stem cells. Previous studies have implicated that both T-bet and Eomes are involved in the generation of effector and central memory CD8 T cells.
A Banerjee, AC Mullen, AM Intlekofer, AM Intlekofer, AM Intlekofer, B Lu, Binfeng Lu, CS Hinrichs, EL Pearce, F Pages, F Sallusto, Gang Li, GM Lord, Hong-Rui Wang, HZ Qui, I Atreya, JT Chang, K Kato, L Gattinoni, L Gattinoni, LJ Chen, M Wiesel, MA Paley, ME Pipkin, Mehrdad Matloubian, N Takemoto, NP Restifo, NS Joshi, Qianting Yang, SJ Szabo, WW Overwijk, X Zhou, Xinchun Chen, Xueguang Zhang, Y Zhang, Y Zhu, Yibei Zhu   +36 more
core   +3 more sources

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Smoking history influences the prognostic value of peripheral naïve CD4+ T cells in advanced non-small cell lung cancer

Cancer Cell International, 2019
Background Considering the effect of smoking on tumor immunity, we attempted to investigate the impact of smoking history on the prognostic value of circulating naïve and memory CD4+ and CD8+ T cells in advanced non-small cell lung cancer (NSCLC) treated
Chao Liu, Bin Xu, Qian Li, Aijie Li, Lan Li, Jinbo Yue, Qinyong Hu, Jinming Yu   +7 more
doaj   +1 more source

Prognostic Implications of Sleep Architecture for Patients Admitted to the Intensive Care Unit With Status Epilepticus

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Status epilepticus (SE) is associated with significant mortality. Sleep architecture may reflect normal brain function. Impaired sleep architecture is associated with poorer outcomes in numerous conditions. Here we investigate the association of sleep architecture in continuous EEG (cEEG) with survival in SE.
Ran R. Liu, Marcus C. Ng, Gavin P. Winston, Sabrina Schaly, Garima Shukla, Lysa Boissé Lomax   +5 more
wiley   +1 more source

Cultural Memory and Survival: The Russian Renaissance of Classical Antiquity in the Twentieth Century [PDF]

, 2009
In this first publication of the UCL SSEES Inaugural Lecture Series, Pamela Davidson dedicates her professorial lecture to the memory of two "outstanding Russian scholars and remarkable individuals, whose contribution to our understanding of classical ...
Davidson, P
core  

Does survival processing enhance implicit memory? [PDF]

Memory & Cognition, 2010
Recent research has shown that human memory may have evolved to remember information that has been processed for the purpose of survival, more so than information that has been processed for other purposes, such as home-moving. We investigated this survival-processing advantage using both explicit and implicit memory tests.
Chi-Shing, Tse, Jeanette, Altarriba
openaire   +2 more sources