Results 91 to 100 of about 1,039,467 (200)

CD49b/CD69-dependent generation of resting T helper cell memory

Frontiers in Immunology, 2013
In the absence of antigen, memory T helper (Th) cells are maintained in a resting state. Recently it has been shown that bone marrow (BM) is a major reservoir of resting memory Th cells.
Asami eHanazawa, Max eLöhning, Max eLöhning, Andreas eRadbruch, Koji eTokoyoda   +4 more
doaj   +1 more source

Proliferation tracing with single-cell mass cytometry optimizes generation of stem cell memory-like T cells. [PDF]

, 2019
Selective differentiation of naive T cells into multipotent T cells is of great interest clinically for the generation of cell-based cancer immunotherapies. Cellular differentiation depends crucially on division state and time.
Bendall, Sean C, Borges, Luciene, Good, Zinaida, Nolan, Garry P, Sahaf, Bita, Samusik, Nikolay, Tibshirani, Robert, Vivanco Gonzalez, Nora   +7 more
core  

Retinoic acid receptor-related orphan receptor α regulates bystander activation of memory CD8+ T cells

Frontiers in Immunology
BackgroundMemory CD8+ T cells sense inflammation and rapidly produce interferon-γ (IFN-γ) independent of cognate antigens. This innate-like property, called bystander activation, is involved in early host defense before the antigen-specific memory ...
Zimeng Cai, Mina Kozai, Hironobu Mita, Hiroto Takeuchi, Satoru Mizuno, Kazuhiro Matsuo, Kensuke Takada   +6 more
doaj   +1 more source

Generation of T-cell memory

Current Opinion in Immunology, 1996
Recent studies of T-cell memory have suggested that the persistent presence of the priming antigen is not necessary for maintenance of CD8 memory. Factors contributing to the development of memory from activated T cells remain ill defined but accumulating data suggest that cytokines play a key role in this process.
openaire   +3 more sources

Differentiation and Protective Capacity of Virus-Specific CD8 [PDF]

, 2017
Noroviruses can establish chronic infections with active viral shedding in healthy humans but whether persistence is associated with adaptive immune dysfunction is unknown.
Bengsch, Bertram, Cosma, Gabriela L., Eisenlohr, Laurence C., Lau, Chi Wai, Manne, Sasikanth, Nice, Timothy J., Palko, Olesya, Pattekar, Ajinkya, Sun, Yuhang, Tacheva, Ralitza, Tomov, Vesselin T., Virgin, Herbert W., Wherry, E. John   +12 more
core   +1 more source

Anti-CD20 therapy depletes activated myelin-specific CD8+ T cells in multiple sclerosis. [PDF]

, 2019
CD8+ T cells are believed to play an important role in multiple sclerosis (MS), yet their role in MS pathogenesis remains poorly defined. Although myelin proteins are considered potential autoantigenic targets, prior studies of myelin-reactive CD8+ T ...
Calabresi, Peter A, Hauser, Stephen L, Sabatino, Joseph J, Schneck, Jonathan P, Wilson, Michael R, Zamvil, Scott S   +5 more
core  

Editorial: Immunometabolism of T cells in skin infection, autoimmunity and cancer biology

Frontiers in Immunology, 2023
Lu Peng, Ling Chen, Laura A. Solt, Venina Marcela Dominical, Zhu Shen   +4 more
doaj   +1 more source

Memory CD8 T cells are vulnerable to chronic IFN-γ signals but not to CD4 T cell deficiency in MHCII-deficient mice

Nature Communications
The mechanisms by which the number of memory CD8 T cells is stably maintained remains incompletely understood. It has been postulated that maintaining them requires help from CD4 T cells, because adoptively transferred memory CD8 T cells persist poorly ...
Ruka Setoguchi, Tomoya Sengiku, Hiroki Kono, Eiryo Kawakami, Masato Kubo, Tadashi Yamamoto, Shohei Hori   +6 more
doaj   +1 more source

Editorial: Tissue Resident Memory T Cells

Frontiers in Immunology, 2019
Fathia Mami-Chouaib, Eric Tartour, Eric Tartour   +2 more
doaj   +1 more source

PHENOTYPIC CHARACTERIZATION AND INTRACELLULAR CYTOKINES OF MEMORY T-CELLS IN MULTIPLE SCLEROSIS PATIENTS AFTER T-CELL VACCINATION

Acta Biomedica Scientifica, 2012
Multiple sclerosis (RS) patients were treated with a vaccine consisted of autological mielin-reactive T-cells. Effector memory CD8+ CD45RO+CD62L- T-cells as well as central memory CD4+ CD45RO+CD62L+ and CD8+ CD45RO+CD62L+ T-cells were significantly ...
I. P. Ivanova, I. V. Savkin, G. V. Seledtsova, A. A. Shishkov, V. I. Seledtsov   +4 more
doaj