Results 161 to 170 of about 1,039,467 (200)
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Nature, 2000
Memory is a long-recognized, crucial and poorly understood property of adaptive immunity. Jacob and Baltimore have designed an elegant genetic approach to marking memory T cells and their precursors irreversibly and have obtained intriguing results.
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Memory is a long-recognized, crucial and poorly understood property of adaptive immunity. Jacob and Baltimore have designed an elegant genetic approach to marking memory T cells and their precursors irreversibly and have obtained intriguing results.
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Journal of Theoretical Biology, 1994
A new mathematical model of T helper-cell activation and proliferation is investigated. The model incorporates recent data and theories about memory T cells. It accounts for the interacting population dynamics of resting, activated and memory T helper cells, interleukin 2 and replicating antigen, and is able to mimic a broad range of available data on ...
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A new mathematical model of T helper-cell activation and proliferation is investigated. The model incorporates recent data and theories about memory T cells. It accounts for the interacting population dynamics of resting, activated and memory T helper cells, interleukin 2 and replicating antigen, and is able to mimic a broad range of available data on ...
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1990
The immune response of the host to its environment necessitates a finely tuned network of feedback mechanisms designed to provide for an effective humoral and cellular response to potential pathogens without damage to self tissues. Therefore the maintenance of the immunological milieu interieur depends not only on counterbalances to regulate the extent
S, Adelstein +3 more
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The immune response of the host to its environment necessitates a finely tuned network of feedback mechanisms designed to provide for an effective humoral and cellular response to potential pathogens without damage to self tissues. Therefore the maintenance of the immunological milieu interieur depends not only on counterbalances to regulate the extent
S, Adelstein +3 more
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Current Opinion in Immunology, 2011
Memory CD4+ T cells specific for a given antigen are generated during the primary response from the effector lymphoblast progeny of naïve precursors. How memory CD4+ T cells differentiate from the effector population is not understood but new tools to assess transcription factor and cytokine expression are allowing for a more careful assessment of this
Justin J, Taylor, Marc K, Jenkins
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Memory CD4+ T cells specific for a given antigen are generated during the primary response from the effector lymphoblast progeny of naïve precursors. How memory CD4+ T cells differentiate from the effector population is not understood but new tools to assess transcription factor and cytokine expression are allowing for a more careful assessment of this
Justin J, Taylor, Marc K, Jenkins
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Current Opinion in Immunology, 2007
The observation that individuals living in malaria endemic areas fail to develop sterilizing immunity to malaria infection has led to the assumption that malaria-specific immune responses are sub-optimal. Recently, T cell receptor (TCR) transgenic mice specific for the sporozoite and blood stages of the malaria parasite have been developed.
Ian A, Cockburn, Fidel, Zavala
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The observation that individuals living in malaria endemic areas fail to develop sterilizing immunity to malaria infection has led to the assumption that malaria-specific immune responses are sub-optimal. Recently, T cell receptor (TCR) transgenic mice specific for the sporozoite and blood stages of the malaria parasite have been developed.
Ian A, Cockburn, Fidel, Zavala
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Nature Cell Biology, 2017
Previous work has highlighted the role of metabolic shifts in regulating the formation of memory T cells, which are generated during a primary infection to provide long-lasting immunity. A study now shows that memory T cells rely on a gluconeogenesis–glycogenolysis cycle to provide antioxidant defence and support their survival.
Joanna, Olivas, Tiffany, Horng
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Previous work has highlighted the role of metabolic shifts in regulating the formation of memory T cells, which are generated during a primary infection to provide long-lasting immunity. A study now shows that memory T cells rely on a gluconeogenesis–glycogenolysis cycle to provide antioxidant defence and support their survival.
Joanna, Olivas, Tiffany, Horng
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Immunological Reviews, 2006
Summary: The pool of memory T cells is regulated by homeostatic mechanisms to persist for prolonged periods at a relatively steady overall size. Recent work has shown that two members of the common γ chain (γc) family of cytokines, interleukin‐7 (IL‐7) and IL‐15, govern homeostasis of memory T cells.
Charles D, Surh +3 more
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Summary: The pool of memory T cells is regulated by homeostatic mechanisms to persist for prolonged periods at a relatively steady overall size. Recent work has shown that two members of the common γ chain (γc) family of cytokines, interleukin‐7 (IL‐7) and IL‐15, govern homeostasis of memory T cells.
Charles D, Surh +3 more
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1990
Generally, it is accepted that immunological memory exists at both the B- and the T-cell level (reviewed in Katz 1977). It has been known for more than 100 years that the persistence of high antibody titers (Fig. 1) can be lifelong after viral infections and that delayed-type hypersensitivity can be demonstrated for a long time by challenging with a ...
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Generally, it is accepted that immunological memory exists at both the B- and the T-cell level (reviewed in Katz 1977). It has been known for more than 100 years that the persistence of high antibody titers (Fig. 1) can be lifelong after viral infections and that delayed-type hypersensitivity can be demonstrated for a long time by challenging with a ...
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T-cell memory: new perspectives
Immunology Today, 1993Immunological memory provides excellent protection against a wide variety of different pathogens. Compared to the primary encounter with antigen, the secondary response is more rapid and effective. So much so, that reexposure often goes unnoticed by the host.
L M, Bradley, M, Croft, S L, Swain
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Annual Review of Immunology, 1991
Three remarkable and unique features of the immune system are specificity, diversity, and memory. Immunological memory involves both T and B cells and results in a secondary antibody response that is faster, of higher affinity, and results in the secretion of non-IgM isotypes of Ig.
E S, Vitetta +5 more
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Three remarkable and unique features of the immune system are specificity, diversity, and memory. Immunological memory involves both T and B cells and results in a secondary antibody response that is faster, of higher affinity, and results in the secretion of non-IgM isotypes of Ig.
E S, Vitetta +5 more
openaire +2 more sources