Results 51 to 60 of about 1,223 (121)
Antiobesity Medications for Older Adults—the New, the Good, the Bad, and the Unknown
Obesity, Volume 33, Issue S1, Page 57-73, November 2025.ABSTRACT Objective Obesity affects 42% of older adults, with rates continuing to rise. This a complex condition influenced by non‐modifiable as well as modifiable risk factors. The disease can be treated through modifications to diet, physical activity, and behavior and more recently through antiobesity medications (AOMs) and surgery. Treatment must be
Anna Pendrey, Javier Sevilla‐Martir
wiley +1 more source
Genomics Review of Selective RET Inhibitors Sensitivity in Thyroid Cancer Clinical Trials
American Journal of Medical Genetics Part C: Seminars in Medical Genetics, Volume 199, Issue 3, Page 228-238, September 2025.ABSTRACT RET gene is a driver of thyroid cancer (TC) tumorigenesis. The incidence of TC has increased worldwide in the last few decades, both in medullary and follicular‐derived subtypes. Several drugs, including multikinase and selective inhibitors, have been explored.
Sara Gil‐Bernabé +5 more
wiley +1 more source
Inherited Susceptibility to Cancer: Past, Present and Future
Annals of Human Genetics, Volume 89, Issue 5, Page 354-365, September 2025.ABSTRACT Germline pathogenic variants (GPVs, ‘mutations’) causing inherited susceptibility to certain cancers (cancer susceptibility genes, CSGs) broadly belong to one of two main classes—loss of function variants in tumour suppressor genes (TSGs) or gain of function variants in proto‐oncogenes (an over‐simplification).
Shirley V. Hodgson +3 more
wiley +1 more source
Clinical and genetic manifestation of pheochromocytoma patients with RET mutation [PDF]
Jichu yixue yu linchuang, 2020 Objective To explore clinical and genetic manifestation of pheochromocytoma patients with RET gene mutation. Methods Clinical data, laboratory examination results and RET gene mutations of 23 pheochromocytoma patients with RET mutation treated in ...
MA Xiao-sen, WANG Fen, CUI Yun-ying, ZHOU Ting, CHEN Shi, LU Lin, TONG An-li, LI Yu-xiu
doaj
CA: A Cancer Journal for Clinicians, Volume 76, Issue 3, May/June 2026.
Lucas Kallas‐Silva +7 more
wiley +1 more source
Mushroom Bioactive Molecules as Anticancerous Agents: An Overview
Food Science &Nutrition, Volume 13, Issue 7, July 2025.This review discusses the molecular mechanisms through which these compounds inhibit cancer progression, including the induction of reactive oxygen species, inhibition of mitotic kinase and angiogenesis, and suppression of topoisomerase activity. By providing the latest insights on these anti‐tumor agents and their pharmacological actions, our review ...
Ali Ikram +10 more
wiley +1 more source
Clinical Medicine Insights: Endocrinology and Diabetes, 2017 Mutations in the VHL, RET, SDHB , and SDHD genes are responsible for von Hippel-Lindau (VHL) disease, multiple endocrine neoplasia type 2 (MEN2), and familial paraganglioma, respectively.
Chutintorn Sriphrapradang +3 more
doaj +1 more source
The diagnostic challenges of medullary thyroid carcinoma: A practical guide for cytopathologists
Cancer Cytopathology, Volume 133, Issue 6, June 2025.Abstract Medullary thyroid carcinoma (MTC) is a rare but potentially aggressive neuroendocrine tumor arising from the thyroid C cells (parafollicular cells) that produce calcitonin, representing 1%–3% of thyroid malignancies but contributing to up to 15% of thyroid cancer‐related deaths.
Marc P. Pusztaszeri, Zahra Maleki
wiley +1 more source
Recent Advances in Diagnostics and Therapeutics for Paediatric Thyroid Cancer
Journal of Paediatrics and Child Health, Volume 61, Issue 5, Page 666-675, May 2025.ABSTRACT Purpose of Review Paediatric thyroid cancer management traditionally relied on extrapolation from adult data and, despite good survival outcomes, often involved extensive surgical approaches and radioactive iodine (RAI) therapy with potentially life‐long complications.
Joel A. Vanderniet +9 more
wiley +1 more source
Diagnosis of Bone Metastasis due to Medullary Thyroid Cancer With 99mTc‐ (V) DMSA SPECT Imaging
Clinical Case Reports, Volume 12, Issue 12, December 2024.ABSTRACT Given the limited availability of PET/CT scans, 99mTc‐(V) DMSA scintigraphy can be used to investigate possible metastases, especially in bone, in individuals with medullary thyroid cancer, even if there are no noticeable signs or symptoms of pain.
Esmaeil Gharepapagh +4 more
wiley +1 more source