RET Proto-Oncogene Variants in Patients with Medullary Thyroid Carcinoma from the Mediterranean Basin: A Brief Report [PDF]
Life, 2023 Multiple endocrine neoplasia type 2 (MEN2) is an autosomal dominant (AD) condition with very high penetrance and expressivity. It is characterized into three clinical entities recognized as MEN2A, MEN2B, and familial medullary thyroid carcinoma (FMTC ...
Vassos Neocleous +4 more
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Distribution of RET proto‐oncogene variants in children with appendicitis [PDF]
Molecular Genetics & Genomic Medicine, 2022 Background In addition to patient‐related systemic factors directing the immune response, the pathomechanisms of appendicitis (AP) might also include insufficient drainage leading to inflammation caused by decreased peristalsis.
Jurek Schultz +7 more
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A study on genetic polymorphism of RET proto-oncogene in Hirschsprung's disease in children [PDF]
African Journal of Paediatric Surgery, 2020 Background: Hirschsprung's disease (HD) is a genetic disorder with a complex pattern of inheritance. Some single-nucleotide polymorphisms (SNPs) are identified to be associated with the risk of Hirschsprung's Disease (HSCR).
Madhu Kumari +5 more
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A post-irradiation-induced replication stress promotes RET proto-oncogene breakage [PDF]
European Thyroid JournalObjective: Ionizing radiation generates genomic instability by promoting the accumulation of chromosomal rearrangements. The oncogenic translocation RET/PTC1 is present in more than 70% of radiation-induced thyroid cancers.
Fabio Hecht +8 more
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Targeted therapy in the treatment of lung cancer in Iceland 2010–2023 [PDF]
Acta OncologicaBackground and purpose: Lung cancer is the third most common malignancy in Iceland and remains the leading cause of cancer-related mortality. Lung cancer may harbor driver mutations affecting the function of Epidermal growth factor receptor (EGFR ...
Stefanía Ásta Tryggvadóttir +8 more
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RET Proto-oncogene C634Y Mutation-associated Multiple Endocrine Adenomatosis Type 2A: a Case Report and Literature Review [PDF]
Zhongguo quanke yixue, 2023 Multiple endocrine adenomatosis type 2A (MEN2A) is a subtype of multiple endocrine adenomatosis type 2, which is clinically characterized by medulloid thyroid carcinoma (MTC) , pheochromocytoma (PHEO) , and hyperparathyroidism, and has been reported to ...
DENG Yuxuan, HE Li, SONG Zhiwang, JIANG Yanxia
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Precious Gene: The Application of RET-Altered Inhibitors
Molecules, 2022 The well-known proto-oncogene rearrangement during transfection (RET), also known as ret proto-oncogene Homo sapiens (human), is a rare gene that is involved in the physiological development of some organ systems and can activate various cancers, such as
Qitao Gou +4 more
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Profiling Oncogenic Germline Mutations in Unselected Chinese Lung Cancer Patients
Frontiers in Oncology, 2021 IntroductionEmerging evidence has suggested that inherited factors are also involved in lung cancer development. However, most studies focused on well-elucidated cancer predisposition genes, the majority of which are tumor suppressor genes.
Jie Yang +7 more
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CRISPR/Cas9 RET Gene Knockout in Medullary Thyroid Carcinoma Cell-lines: Optimization and Validation
Iranian Journal of Public Health, 2022 Background: Medullary Thyroid Cancer (MTC) is a very aggressive type of thyroid carcinoma. Mutation in RET proto-oncogene is demonstrated in MTC development. We aimed to knock-out of RET-oncogene using CRISPR/Cas9 genome editing method in MTC cell-lines.
Marjan Zarif-Yeganeh +5 more
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BMC Endocrine Disorders, 2020 Background Hereditary medullary thyroid carcinoma (MTC) is mainly caused by germline mutations in the RET proto-oncogene, which accounts for 20–30% of all MTC according to foreign studies.
Qin Huang, Aihua Hu, Mingsheng Zhang
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