Results 41 to 50 of about 14,919 (139)

Rapid and long-lasting response to selpercatinib of paraneoplastic Cushing’s syndrome in medullary thyroid carcinoma

European Thyroid Journal, 2023
The endocrine secretions of carcinomas can be life-threatening. Medullary thyroid carcinoma (MTC) is a rare cancer that is often associated with cortisol secretion, leading to paraneoplastic Cushing’s syndrome.
Marine Sitbon, Porhuoy Chou, Seydou Bengaly, Brigitte Poirot, Marie Laloi-Michelin, Laure Deville, Atanas Pachev, Ahouefa Kowo-Bille, Clement Dumont, Cécile N Chougnet   +9 more
doaj   +1 more source

The nitty‐gritty of vascular permeability in cancer: targeting blood endothelium to control metastases

British Journal of Pharmacology, EarlyView.
Blood vascular permeability is a hallmark of cancer and acts as an active driver of metastatic dissemination. Metastasis accounts for the vast majority of cancer deaths, yet most work has focussed on tumour‐intrinsic traits and angiogenesis, while the specific contribution of endothelial barrier regulation to intravasation and extravasation remains ...
Pierre Boucher, Mérone Da Costa Oliveira, Adrien Levesque, Alexandre Rutault, Patrick Savoyaud, Nicolas Bréchot, Stéphane Germain   +6 more
wiley   +1 more source

Targeting KRAS for cancer therapy

British Journal of Pharmacology, EarlyView.
In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia, Ruonan Liu, Tonia A. Adamide, Isis E. Fernandez, Georgios T. Stathopoulos   +4 more
wiley   +1 more source

Diagnostic Accuracy of Next Generation Sequencing Panel using Circulating Tumor DNA in Patients with Advanced Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis

Journal of Health Economics and Outcomes Research, 2020
**Background/Objectives:** Until now, no meta-analysis has been published to evaluate the diagnostic performance of next-generation sequencing (NGS) panel using circulating tumor (ctDNA) in patients with advanced non-small cell lung cancer (aNSCLC).
Mariana M. Sebastião, Rodrigo S. Ho, João Paulo V. de Carvalho, Micha Nussbaum   +3 more
doaj   +1 more source

The role of the ShcD and RET interaction in neuroblastoma survival and migration

Biochemistry and Biophysics Reports, 2018
Preliminary screening data showed that the ShcD adaptor protein associates with the proto-oncogene RET receptor tyrosine kinase. In the present study, we aimed to investigate the molecular interaction between ShcD and RET in human neuroblastoma cells and
Zeanap A. Mabruk, Samrein B.M. Ahmed, Asha Caroline Thomas, Sally A. Prigent   +3 more
doaj   +1 more source

Predicting phenotypic severity of uncertain gene variants in the RET proto-oncogene. [PDF]

PLoS ONE, 2011
Although reported gene variants in the RET oncogene have been directly associated with multiple endocrine neoplasia type 2 and hereditary medullary thyroid carcinoma, other mutations are classified as variants of uncertain significance (VUS) until the ...
David K Crockett, Stephen R Piccolo, Perry G Ridge, Rebecca L Margraf, Elaine Lyon, Marc S Williams, Joyce A Mitchell   +6 more
doaj   +1 more source

Comprehensive Genomic Profiling Beyond Driver Testing in Non‐Squamous Non‐Small Cell Lung Cancer With Known Drivers

Cancer Science, EarlyView.
Figure 6 Comprehensive genomic profiling identified additional actionable alterations in a substantial proportion of patients with non‐squamous NSCLC despite previously identified driver alterations, with some findings leading to subsequent matched targeted therapies.
Yoshihiro Masui, Tatsuya Yoshida, Yoh Yamaguchi, Jun Miyakoshi, Ryoko Inaba Higashiyama, Akiko Tateishi, Yuki Shinno, Yuji Matsumoto, Yusuke Okuma, Tomonori Mizutani, Hidehito Horinouchi, Kouya Shiraishi, Takashi Kohno, Takafumi Koyama, Noboru Yamamoto, Yasushi Goto   +15 more
wiley   +1 more source

Vaginal delivery in a patient with pheochromocytoma, medullary thyroid cancer, and primary hyperparathyroidism (multiple endocrine neoplasia type 2A, Sipple′s syndrome)

Saudi Journal of Anaesthesia, 2014
Multiple endocrine neoplasia 2A (MEN 2A), or Sipple′s syndrome is a rare inherited dominant syndrome, characterised by medullary thyroid carcinoma, adrenal pheochromocytoma and hyperparathyroidism, due to specific RET proto-oncogene mutations.
Muhammad Anas Muzannara, Nasser Tawfeeq, Mahmood Nasir, Mohammed Khulaif Al Harbi, Georges Geldhof, Vassilios Dimitriou   +5 more
doaj   +1 more source

Detection of NTRK1/2/3 rearrangements in pigmented spindle cell naevus of Reed: a comparative study of optimized pan‐TRK immunohistochemistry, FISH and RNA‐NGS

Histopathology, EarlyView.
Pigmented spindle cell nevus of Reed (PSCN) is a subtype of Spitz nevus mainly characterized by MYO5A::NTRK3 fusion. Our optimized pan‐TRK protocol stained 16/79 (20.3%) PSCNs (diffuse, granular, cytoplasmic staining of moderate intensity) and revealed high values of specificity (94.4%–96.2%) and positive predictive value (92.3%) for the detection of ...
Costantino Ricci, Barbara Corti, Sara Coluccelli, Giulia Calafato, Debora Anconelli, Francesco Vasuri, Martina Lambertini, Federico Venturi, Biagio Scotti, Alessia Grillini, Eugenia Franchini, Thais Maloberti, Antonio De Leo, Giovanni Tallini, Elisa Gruppioni, Annalisa Altimari, Michelangelo Fiorentino, Gerardo Cazzato, Emi Dika, Dario de Biase   +19 more
wiley   +1 more source

Point Mutations in RET Proto-Oncogene Exon 10 in Patients with Medullary Thyroid Carcinoma [PDF]

Journal of Kerman University of Medical Sciences, 2015
Background & Aims: Thyroid cancer is the most common endocrine malignancy. Medullary thyroid carcinoma (MTC) is an aggressive malignant tumor arising from parafollicular cells of the thyroid.
Marjan Zarif-Yeganeh, Sara Sheikholeslami, Golnoush Dehbashi-Behbahani, Samaneh Farashi, Laleh Hoghooghi-Rad, Fereidoun Azizi, Mehdi Hedayati   +6 more
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