Results 61 to 70 of about 14,919 (139)
Expression of C-terminal ALK, RET, or ROS1 in lung cancer cells with or without fusion
BMC Cancer, 2019 Background Genetic alterations, including mutation of epidermal growth factor receptor or v-Ki-ras2 kirsten rat sarcoma viral oncogene homolog and fusion of anaplastic lymphoma kinase (ALK), RET proto-oncogene (RET), or v-ros UR2 sarcoma virus oncogene ...
Koh Furugaki +5 more
doaj +1 more source
MedComm, Volume 7, Issue 10, October 2026.Envonalkib provides robust and durable benefit in treatment‐naïve ALK‐positive NSCLC, with median PFS of 30.4 months versus 12.0 months for crizotinib. Exploratory biomarker analyses showed that concurrent driver alterations and p53 pathway dysfunction reduce treatment efficacy.
Jie Huang +25 more
wiley +1 more source
RET Proto-Oncogene-Not Such an Obvious Starting Point in Cancer Therapy. [PDF]
Cancers (Basel), 2022 Kucharczyk T +5 more
europepmc +1 more source
Cancer Cell Metastasis: From Molecular Mechanisms to Therapeutic Strategies
MedComm, Volume 7, Issue 10, October 2026.The schematic representation of intrinsic and extrinsic influences of cancer cell metastasis. Genomic evolution of metastatic tumor cells (MTCs) promotes their metastatic phenotypes and reconstruct the primary tumor microenvironment. During MTCs migration along different routes (blood circulation, lymphatic vessels, and perineuronal spaces), the ...
Yupeng Zhao +7 more
wiley +1 more source
Iranian Journal of Public Health, 2014 Medullary thyroid carcinoma (MTC) occurs in both sporadic (75%) and hereditary (25%) forms. The missense mutations of the REarranged during Transfection (RET) proto-oncogene in MTC development have been well demonstrated.
Sara Sheikholeslami +4 more
doaj
Medullary Thyroid Cancer – Feature Review and Update on Systemic Treatment
Acta Clinica Croatica, 2020 Medullary thyroid carcinoma (MTC) is a rare malignancy that originates from parafollicular (C cells) of the thyroid and accounts for 2-4% of all thyroid malignancies. MTC may be sporadic or inherited, the latter as part of the MEN 2 syndromes. Germline
Nina Dabelić +2 more
doaj
European Journal of Histochemistry, 2009 Glial cell line-derived neurotrophic factor (GDNF) is a growth factor promoting the survival of several neuronal populations in the central, peripheral and autonomous nervous system.
C Lucini +3 more
doaj +1 more source
MedComm, Volume 7, Issue 10, October 2026.Colorectal cancer is a heterogeneous, adaptive disease shaped by population‐level risk, genomic and epigenetic alterations, tumor ecosystem evolution, and treatment pressure. This review integrates epidemiology, risk factors, signaling networks, clinical presentation, screening, molecular diagnosis, and stage‐ and biomarker‐guided management while ...
Kairui Wan +6 more
wiley +1 more source
A Vietnamese MEN2A syndrome patient with C634G germline mutation of the RET proto-oncogene
Journal of Clinical and Translational Endocrinology Case Reports, 2019 Multiple endocrine neoplasia type 2A (MEN 2A) is a rare, autosomal dominant disease. It is characterized by complete penetrance of medullary thyroid carcinoma (MTC), lower prevalence of pheochromocytoma, hyperparathyroidism, and sometimes cutaneous ...
Pham Le Bich Hang +7 more
doaj +1 more source
A 4-Year-Old Boy with an Accidentally Detected Mutation in the RET Proto-Oncogene and Mutation in the Gene Encoding the Ryanodine Receptor1 (RyR1)-Case Report. [PDF]
Children (Basel), 2023 Mierzwa M +6 more
europepmc +1 more source