Results 101 to 110 of about 164,706 (214)

Promise and Peril of a Genotype‐First Approach to Mendelian Cardiovascular Disease

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Precision medicine, which among other aspects includes an individual's genomic data in diagnosis and management, has become the standard‐of‐care for Mendelian cardiovascular disease (CVD).
Babken Asatryan, Brittney Murray, Rafik Tadros, Marina Rieder, Ravi A. Shah, Ghaith Sharaf Dabbagh, Andrew P. Landstrom, Stephan Dobner, Patricia B. Munroe, Christopher M. Haggerty, Argelia Medeiros‐Domingo, Anjali T. Owens, Iftikhar J. Kullo, Christopher Semsarian, Tobias Reichlin, Andreas S. Barth, Dan M. Roden, Cynthia A. James, James S. Ware, C. Anwar A. Chahal   +19 more
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Causal association of plasminogen activators and their inhibitors with Alzheimer’s disease: a Mendelian randomization study

Archives of Medical Science
Introduction Alzheimer’s disease (AD) is the most common cause of dementia and contributes to a huge burden of disease worldwide. Observational studies have found that tissue plasminogen activator (t-PA) inhibits the development of AD, but little is ...
Xin Guo, Fangyu Gao, Baolong Pan, Feng Gao, Jingsi Zhang, Shanshan Wang, Qiao Niu   +6 more
doaj   +1 more source

Mendelian Randomisation: Concepts, Opportunities, Challenges, and Future Directions

Global Heart
Mendelian randomisation is an approach in genetic epidemiology that uses genetic variants as instrumental variables to investigate the causal relationship between genetically proxied exposures and health outcomes.
Sophie C. de Ruiter, Lena Tschiderer, Diederick E. Grobbee, Peter Willeit, Hester M. den Ruijter, A. Floriaan Schmidt, Sanne A. E. Peters   +6 more
doaj   +1 more source

Causal association between periodontitis and systemic diseases: a systematic review and meta-analysis of mendelian randomization studies

BMC Oral Health
Background Periodontitis has increasingly been recognized for its impact on systemic health. Mendelian Randomization (MR), an emerging causal inference method, effectively overcomes confounding biases in observational studies.
Yanghao Zhao, Churen Zhang, Xiaochi Chang, Jie Zhang, Chang Shu, Cheng Lin, Jianxia Hou   +6 more
doaj   +1 more source

Mendelian Randomization Analysis Supports a Causal Relationship Between Circulating Inflammatory Proteins and Basal Cell Carcinoma [PDF]

Zhi-da Fu,1,2,* Yao Wang,3,* Hong-li Yan,2 Jian-hua Wu1 1Department of Dermatology, Changhai Hospital, Naval Medical University, Shanghai, People’s Republic of China; 2Center for Reproductive Medicine, Changhai Hospital, Naval Medical University,
Yan HL, Fu ZD, Wang Y, Wu JH
core   +1 more source

A Two-Sample Mendelian Randomization Study of Basophil Count and Risk of Gestational Diabetes Mellitus [PDF]

Jing Mao,* Yanqiong Gan,* Xinlin Tan, Yuhan He, Qiao Jing, Qi Shi Affiliated Hospital of North Sichuan Medical College, Nanchong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qi Shi, Affiliated ...
Tan X, He Y, Shi Q, Jing Q, Gan Y, Mao J
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Combined Transcriptomic and Mendelian Randomisation Explores the Diagnostic Value of Ubiquitination-Related Genes in Sepsis [PDF]

Xue Bai,1,* RuXing Liu,2,* Yujiao Tang,2,* LiTing Yang,1 Zesu Niu,2 Yi Hu,2 Ling Zhang,1 MengFei Chen1 1Department of Emergency, People’s Hospital of Ningxia Hui Autonomous Region, Yinchuan, People’s Republic of China; 2Department of ...
Yang L, Hu Y, Chen M, Niu Z, Liu R, Zhang L, Bai X, Tang Y   +7 more
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Sex-Stratified Bidirectional Mendelian Randomization Analysis of Eating Habits and Female Pelvic Peritoneal Adhesions [PDF]

Tiantian Dai, Dandan Chu, Meng Yu, Jianfei Zu, Yanshuang Jia, Yi Zhang Department of Obstetrics and Gynecology, Changning Maternity and Infant Health Hospital, East China Normal University, Shanghai, 200050, People’s Republic of ChinaCorrespondence: Yi ...
Yu M, Chu D, Zhang Y, Jia Y, Dai T, Zu J
core   +1 more source

Bidirectional Two-Sample Mendelian Randomization Analysis Reveals Causal Associations Between Modifiable Risk Factors and Fibromyalgia [PDF]

Wei Zu,1,* Shaojiong Zhou,2,* Tao Du,1 Chenyanwen Zhu,3 Siyue Nie,4 Hongwei Zhu1 1Department of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Department of Neurology & Innovation ...
Nie S, Du T, Zhou S, Zu W, Zhu H, Zhu C
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Exploring causal correlations between oily fish intake and multiple sclerosis: A two-sample Mendelian randomization study. [PDF]

Asia Pac J Clin Nutr
Chang S, Shi K, Zhang M.
europepmc   +1 more source