World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT Background Chronic rhinosinusitis (CRS) and nasal polyps (NP) are chronic inflammatory conditions with unsatisfactory treatment outcomes due to frequent recurrence of refractory disease. Identifying new therapeutic targets is essential. Methods We conducted a proteome‐wide Mendelian randomization (MR) analysis by integrating genome‐wide ...
En Zhou +4 more
wiley +1 more source
Sex Hormones and the Risk of Nasal Polyps: A Two‐Sample Mendelian Randomization Study
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT Objective The pathophysiological roles of sex hormones in airway inflammation have drawn much attention recently. We aimed to explore the causal effect of sex hormones on chronic rhinosinusitis (CRS) and nasal polyps (NP) via a Mendelian randomization (MR) study.
Ying Zhu +7 more
wiley +1 more source
Machine Learning and Mendelian Randomization Identify Allergic Rhinitis as Nasopharyngeal Carcinoma Risk Factor With Validated Potential Candidate Biomarkers. [PDF]
Int J GenomicsChen M +5 more
europepmc +1 more source
From Yeast to Therapeutics: Modeling Neurodegenerative Diseases in Saccharomyces cerevisiae
Yeast, EarlyView.Yeast plasmids expressing human Aβ‐42, α‐syn, htt, and TDP‐43. Their fate includes an equilibrium between the endocytic pathway and aggregates that potentially disrupt endocytosis, vesicular transport, vacuolar autophagy, and mitochondrial activity. ABSTRACT Here, we review the use of Saccharomyces cerevisiae as a powerful model organism for studying ...
Jose Ribamar Ferreira‐Junior +2 more
wiley +1 more source
Exploring the causal pathways and mediating effects of sociopsychological factors on chronic coronary syndrome: A Mendelian randomization study. [PDF]
Medicine (Baltimore)Li X, Wang Y, Song C, Guo X.
europepmc +1 more source
Causal relationship between genetically predicted mental disorders and frailty: a bidirectional and multivariable mendelian randomization study [PDF]
Wenxi Sun +6 more
openalex +1 more source
Genetic Pigmentary Disorders: From Molecular Mechanisms to Clinical Manifestations
The Journal of Dermatology, EarlyView.ABSTRACT Genetic pigmentary disorders represent a diverse group of genetic conditions characterized by alterations in melanin production and transport and melanocyte development, resulting from single‐gene pathological variants. These disorders encompass both hypopigmentary and hyperpigmentary phenotypes, affecting not only skin pigmentation but also ...
Ken Okamura, Tamio Suzuki
wiley +1 more source
The causal relationship between atopic dermatitis and retinal detachment: A 2-sample Mendelian randomization analysis. [PDF]
Medicine (Baltimore)Liu X, Li H, Tang T, Zhu Y, Zhu S.
europepmc +1 more source