Songorine inhibits mitophagy in chronic heart failure via the TBC1D15/Fis1/Rab7A pathway
British Journal of Pharmacology, EarlyView.Abstract Background and purpose Songorine (SGR) is an alkaloid extracted from Aconitum carichaelii Debx. and has a demonstrated role in cardiac dysfunction. Chronic heart failure (CHF) is a severe clinical syndrome leading to functional impairment and death, primarily due to the deterioration of energy metabolism in cardiomyocytes. However, the precise
Wenxiu Liu +4 more
wiley +1 more source
The role of inflammatory cytokines and blood metabolites in osteoporosis: A Mendelian randomization study on pathways and therapeutic targets. [PDF]
Medicine (Baltimore)Liu Y +6 more
europepmc +1 more source
A century of theories of balancing selection
Biological Reviews, EarlyView.ABSTRACT Traits that affect organismal fitness are often highly genetically variable. This genetic variation is vital for populations to adapt to their environments, but it is also surprising given that nature – after all – ‘selects’ the best genotypes at the expense of those that fall short.
Filip Ruzicka +10 more
wiley +1 more source
Causal associations between cognitive impairments and retinal diseases: A two-sample Mendelian randomization study. [PDF]
J Int Med ResShi Q +5 more
europepmc +1 more source
Cancer Science, EarlyView.This study indicates that SPP1, as an important regulator of tumor progression, is upregulated in various tumors and has been associated with a poor prognosis. SPP1+M2 has a unique spatial location at the forefront of tumor invasion and metastasis, thereby promoting tumor progression. MARCO+M2, which forms a mutually exclusive relationship with SPP1+M2,
Xuan Luo +15 more
wiley +1 more source
Mendelian randomization analysis unveils causal associations between immune cells, metabolites, and lung cancer risk. [PDF]
Discov OncolMao Y, Fu T, Wang Y, Wang L.
europepmc +1 more source
The Impact of Conventional Stroke Risk Factors on Early and Late Onset Ischemic Stroke: a Mendelian Randomization Study [PDF]
Kevin T.K. Nguyen +11 more
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Effect Modification by Cofactors in the Impact of Body Mass Index Change on the Risk of Lung Cancer
Cancer Science, EarlyView.Persistent overweight or obesity, and BMI gain from normal to overweight or obesity, were consistently associated with reduced lung cancer risk, with stronger associations among men and ever smokers. Persistent underweight and BMI loss were associated with increased lung cancer risk, particularly in men. The protective effect of obesity and BMI gain is
Su Youn Nam, Junwoo Jo, Sun Ha Choi
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Clinical Genetics, EarlyView.A novel CPAMD8 nonsense mutation c.2679C>G (p.Tyr893*) was identified in a patient with congenital microcoria, leading to reduced mRNA expression and predicted protein truncation. ABSTRACT Congenital microcoria (MCOR) is a rare inherited ocular disorder. Here, we describe a novel nonsense variant in the CPAMD8 gene in a patient with MCOR.
Jing‐Fan Gao +4 more
wiley +1 more source