Results 231 to 240 of about 133,969 (268)

Polygenic Mendelian Randomization

Cold Spring Harbor Perspectives in Medicine, 2020
Many exposures considered in Mendelian randomization (MR) studies are polygenic in that they are influenced by thousands of genetic variants. By using many single-nucleotide polymorphisms (SNPs) as instrumental variables, more variation in the exposure is explained, increasing the precision of MR.
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Spatial Mendelian games

Mathematical Biosciences, 1998
This paper considers complex models arising in sociobiology. These combine genetic and strategic aspects to model the effect of gene-linked strategies on the ability of individuals to survive to maturity, mate and produce offspring. Several important models considered in the literature are generalised and extended to incorporate a spatial aspect ...
Radcliffe, J., Rass, L.
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Mendelian etiologies of stroke

Annals of Neurology, 1987
AbstractThere are many genetic disorders associated with an increased risk for stroke that may easily be overlooked in the valuation of both adult and pediatric acute stroke victims. The recognition of a genetic disorder as the cause of a stroke has important implications not only for the immediate care of the stroke victim, but often also for others ...
M, Natowicz, R I, Kelley
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Maverick against the Mendelians

Scientific American, 2008
The article describes a theory that has been suggested by scientist Michael Wigler, which attempts to explain the genetic basis of autism. The author explains that Wigler's theory relies on the assumption that women are more likely to carry the gene and pass it on to their male offspring than to develop the disease themselves. INSET: MICHAEL WIGLER.
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MENDELIAN HYPERPHENYLALANINEMIA

Annual Review of Genetics, 1988
C R, Scriver, S, Kaufman, S L, Woo
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Mendelian inheritance

Nature Ecology & Evolution, 2022
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Understanding Mendelian Randomization

Clinical Spine Surgery
Mendelian randomization (MR) is a statistical method that is rising in popularity. Although randomized controlled trials (RCTs) remain the gold standard in terms of inferring causality, they are not always feasible due to time, ethical, and resource constraints.
Garrison P. Bentz, Mark J. Lambrechts
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Testing and correcting for weak and pleiotropic instruments in two‐sample multivariable Mendelian randomization

Statistics in Medicine, 2021
Eleanor Sanderson, Wes Spiller, Jack Bowden   +2 more
exaly  

Health effects of high serum calcium levels: Updated phenome-wide Mendelian randomisation investigation and review of Mendelian randomisation studies

EBioMedicine, 2022
Shuai Yuan, Wanglong Gou, Lijuan Wang
exaly  

Mendelian Randomization Concerns

JAMA Psychiatry, 2018
Lin, Bochao Danae, Li, Yue, Luykx, Jurjen   +2 more
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