Results 221 to 230 of about 248,446 (274)
Association of Inflammatory Proteins with Neuropathic Pain: A Two-Sample Bidirectional Mendelian Randomization. [PDF]
J Pain ResZhong J +6 more
europepmc +1 more source
Association Between Waist Circumference and Coronary Artery Disease: Evidence from the NHANES 1999-2023 Cross-Sectional Data and Mendelian Randomization Analysis. [PDF]
Glob HeartChen L, Shang Q, Li Y.
europepmc +1 more source
Revealing causal associations of 91 inflammatory protein factors with endocarditis: Insights from genome-wide association study. [PDF]
Medicine (Baltimore)Jiang X, Guan Y, Chen C, Wu X.
europepmc +1 more source
Repurposing drugs for the prevention of vascular dementia using evidence from drug target Mendelian randomization. [PDF]
Nat AgingTaylor-Bateman V +8 more
europepmc +1 more source
Nature Reviews Methods Primers, 2022 Mendelian randomization (MR) is a term that applies to the use of genetic variation to address causal questions about how modifiable exposures influence different outcomes. The principles of MR are based on Mendel's laws of inheritance and instrumental variable estimation methods, which enable the inference of causal effects in the presence of ...
Eleanor Sanderson +2 more
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JAMA - Journal of the American Medical Association, 2017
Confounding and reverse causality have prevented us from drawing meaningful clinical interpretation even in well-powered observational studies. Confounding may be attributed to our inability to randomize the exposure variable in observational studies. Mendelian randomization (MR) is one approach to overcome confounding.
Connor A Emdin, Sekar Kathiresan
exaly +5 more sources
Confounding and reverse causality have prevented us from drawing meaningful clinical interpretation even in well-powered observational studies. Confounding may be attributed to our inability to randomize the exposure variable in observational studies. Mendelian randomization (MR) is one approach to overcome confounding.
Connor A Emdin, Sekar Kathiresan
exaly +5 more sources
Cold Spring Harbor Perspectives in Medicine, 2021
Mendelian randomization borrows statistical techniques from economics to allow researchers to analyze the effects of the environment, drug treatments, and other factors on human biology and disease. Taking advantage of the fact that genetic variation is randomized among children from the same parents, it allows genetic variants known to influence ...
openaire +2 more sources
Mendelian randomization borrows statistical techniques from economics to allow researchers to analyze the effects of the environment, drug treatments, and other factors on human biology and disease. Taking advantage of the fact that genetic variation is randomized among children from the same parents, it allows genetic variants known to influence ...
openaire +2 more sources
Colorectal Cancer Risk between Mendelian and Non-Mendelian Inheritance
Clinics in Colon and Rectal Surgery, 2023AbstractHereditary colorectal cancer has been an area of focus for research and public health practitioners due to our ability to quantify risk and then act based on such results by enrolling patients in surveillance programs. The wide access to genetic testing and whole-genome sequencing has resulted in identifying many low/moderate penetrance genes ...
Elizabeth A, Hibler +2 more
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Mathematical Biosciences, 1998
This paper considers complex models arising in sociobiology. These combine genetic and strategic aspects to model the effect of gene-linked strategies on the ability of individuals to survive to maturity, mate and produce offspring. Several important models considered in the literature are generalised and extended to incorporate a spatial aspect ...
Radcliffe, J., Rass, L.
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This paper considers complex models arising in sociobiology. These combine genetic and strategic aspects to model the effect of gene-linked strategies on the ability of individuals to survive to maturity, mate and produce offspring. Several important models considered in the literature are generalised and extended to incorporate a spatial aspect ...
Radcliffe, J., Rass, L.
openaire +3 more sources