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Unveiling the clinical connections between vitamin B12 deficiency anemia, Hashimoto thyroiditis, and hypothyroidism: New insights from Mendelian randomization studies. [PDF]
Medicine (Baltimore)Chen L +6 more
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JAMA, 2017
Confounding and reverse causality have prevented us from drawing meaningful clinical interpretation even in well-powered observational studies. Confounding may be attributed to our inability to randomize the exposure variable in observational studies. Mendelian randomization (MR) is one approach to overcome confounding.
Sandeep, Grover +3 more
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Confounding and reverse causality have prevented us from drawing meaningful clinical interpretation even in well-powered observational studies. Confounding may be attributed to our inability to randomize the exposure variable in observational studies. Mendelian randomization (MR) is one approach to overcome confounding.
Sandeep, Grover +3 more
openaire +4 more sources
Cold Spring Harbor Perspectives in Medicine, 2021
Mendelian randomization borrows statistical techniques from economics to allow researchers to analyze the effects of the environment, drug treatments, and other factors on human biology and disease. Taking advantage of the fact that genetic variation is randomized among children from the same parents, it allows genetic variants known to influence ...
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Mendelian randomization borrows statistical techniques from economics to allow researchers to analyze the effects of the environment, drug treatments, and other factors on human biology and disease. Taking advantage of the fact that genetic variation is randomized among children from the same parents, it allows genetic variants known to influence ...
openaire +2 more sources
Mendelian and non-Mendelian heredity: a reappraisal
Proceedings of the Royal Society of London. Series B. Biological Sciences, 1966Abstract The first report of a non-Mendelian gene (Correns 1908) appeared just eight years after the rediscovery of Mendel’s laws and, in this sense, Mendelian and non-Mendelian heredity have both been available for analysis and comparison for almost sixty years.
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Mendelian randomization for nephrologists
Kidney International, 2023Confounding is a major limitation of observational studies. Mendelian randomization (MR) is a powerful study design that uses genetic variants as instrumental variables to enable examination of the causal effect of an exposure on an outcome in observational data.
Ellen Dobrijevic +5 more
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Mendelian Phenotypes in the Netherlands
Human Heredity, 1993We report here a database listing Mendelian phenotypes described in the Netherlands and/or in populations originating from this country, and describe the results of a quantitative analysis of the database. The database is specifically directed at the presence, frequency and origin of the phenotypes.
J B, Verheij, L P, ten Kate
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On the origins of the Mendelian laws
Journal of Heredity, 1984The two laws usually attributed to Mendel were not considered as laws by him. The first law, the law of independent segregation occurs in Mendel's paper as an assumption or hypothesis. Hugo de Vries refers to this as a law discovered by Mendel. This appears to be the first use of an expression equivalent to Mendel's law.
F, Monaghan, A, Corcos
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Postgraduate Medicine, 1972
The first approach to analysis of the inheritance pattern of mendelian diseases depends on whether the mutant gene or genes are located on one of the 44 (22 pairs) autosomes or on the one or two X chromosomes. No human disease is known to be associated with a mutant gene on the Y chromosome.
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The first approach to analysis of the inheritance pattern of mendelian diseases depends on whether the mutant gene or genes are located on one of the 44 (22 pairs) autosomes or on the one or two X chromosomes. No human disease is known to be associated with a mutant gene on the Y chromosome.
openaire +2 more sources